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Alfonso  Luque

Alfonso Luque


Ph.D. in Biological Sciences, Department of Biochemistry and Molecular Biology, University Complutense, Madrid, Spain, 1997

Current position

Researcher (Miguel Servet Programme), Pharmacology Therapies Unit, Research institute for Rare diseases (IIER), Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid

Publications (since 2010)

  1. Jimenez-Garcia, L., Herranz, S., Luque, A. and Hortelano, S. (2015). Critical role of p38 MAPK in IL-4-induced alternative activation of peritoneal macrophages. Eur J Immunol 45(1): 273-286.
  2. Gomez, A. M., Martinez, C., Gonzalez, M., Luque, A., Melen, G. J., Martinez, J., Hortelano, S., Lassaletta, A., Madero, L. and Ramirez, M. (2015). Chemokines and relapses in childhood acute lymphoblastic leukemia: A role in migration and in resistance to antileukemic drugs. Blood Cells Mol Dis 55(3): 220-227.
  3. Castro, R., Bromage, E., Abos, B., Pignatelli, J., Gonzalez Granja, A., Luque, A. and Tafalla, C. (2014). CCR7 is mainly expressed in teleost gills, where it defines an IgD+IgM- B lymphocyte subset. J Immunol 192(3): 1257-1266.
  4. Luque, A., Gonzalez Granja, A., Gonzalez, L. and Tafalla, C. (2014). Establishment and characterization of a rainbow trout heart endothelial cell line with susceptibility to viral hemorrhagic septicemia virus (VHSV). Fish Shellfish Immunol 38(1): 255-264.
  5. Traves, P. G., Lopez-Fontal, R., Cuadrado, I., Luque, A., Bosca, L., de las Heras, B. and Hortelano, S. (2013). Critical role of the death receptor pathway in the antitumoral effects induced by hispanolone derivatives. Oncogene 32(2): 259-268.
  6. Dixon, B., Luque, A., Abos, B., Castro, R., Gonzalez-Torres, L. and Tafalla, C. (2013). Molecular characterization of three novel chemokine receptors in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol 34(2): 641-651.
  7. Traves, P. G., Pimentel-Santillana, M., Carrasquero, L. M., Perez-Sen, R., Delicado, E. G., Luque, A., Izquierdo, M., Martin-Sanz, P., Miras-Portugal, M. T. and Bosca, L. (2013). Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses. J Immunol 190(8): 4226-4235.
  8. Mirones, I., de Prada, I., Gomez, A. M., Luque, A., Martin, R., Perez-Jimenez, M. A., Madero, L., Garcia-Castro, J. and Ramirez, M. (2013). A role for the CXCR3/CXCL10 axis in Rasmussen encephalitis. Pediatr Neurol 49(6): 451-457 e451.
  9. Abos, B., Castro, R., Pignatelli, J., Luque, A., Gonzalez, L. and Tafalla, C. (2013). Transcriptional heterogeneity of IgM+ cells in rainbow trout (Oncorhynchus mykiss) tissues. PLoS One 8(12): e82737.
  10. Traves, P. G., Luque, A. and Hortelano, S. (2012). Tumor suppressor ARF: The new player of innate immunity. Oncoimmunology 1(6): 946-947.
  11. Herranz, S., Traves, P. G., Luque, A. and Hortelano, S. (2012). Role of the tumor suppressor ARF in macrophage polarization: Enhancement of the M2 phenotype in ARF-deficient mice. Oncoimmunology 1(8): 1227-1238.
  12. Traves, P. G., Luque, A. and Hortelano, S. (2012). Macrophages, inflammation, and tumor suppressors: ARF, a new player in the game. Mediators Inflamm 2012: 568783.
  13. Palazon, A., Teijeira, A., Martinez-Forero, I., Hervas-Stubbs, S., Roncal, C., Penuelas, I., Dubrot, J., Morales-Kastresana, A., Perez-Gracia, J. L., Ochoa, M. C., Ochoa-Callejero, L., Martinez, A., Luque, A., Dinchuk, J., Rouzaut, A., Jure-Kunkel, M. and Melero, I. (2011). Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes. Cancer Res 71(3): 801-811.
  14. Traves, P. G., Lopez-Fontal, R., Luque, A. and Hortelano, S. (2011). The tumor suppressor ARF regulates innate immune responses in mice. J Immunol 187(12): 6527-6538.
  15. Zovein, A. C., Luque, A., Turlo, K. A., Hofmann, J. J., Yee, K. M., Becker, M. S., Fassler, R., Mellman, I., Lane, T. F. and Iruela-Arispe, M. L. (2010). Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev Cell 18(1): 39-51.
  16. Chen, T. T., Luque, A., Lee, S., Anderson, S. M., Segura, T. and Iruela-Arispe, M. L. (2010). Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. J Cell Biol 188(4): 595-609.
  17. Hortelano, S., Lopez-Fontal, R., Traves, P. G., Villa, N., Grashoff, C., Bosca, L. and Luque, A. (2010). ILK mediates LPS-induced vascular adhesion receptor expression and subsequent leucocyte trans-endothelial migration. Cardiovasc Res 86(2): 283-292.
Protocols by Alfonso Luque
  1. Chitin-challenged Mice Model to Study M2 Macrophages Polarization
  2. Thioglycollate-elicited Peritoneal Macrophages Preparation and Arginase Activity Measurement in IL-4 Stimulated Macrophages