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Nabil Djouder

Education

Ph.D. in Molecular Pharmacology and Parmacochemistry, University Louis Pasteur (ULP), Strasbourg, France, 2001

Current position

Junior Group Leader at CNIO in Madrid, Spain, working in the Cancer Cell Biology Programme directed by Prof. Dr. Erwin Wagner (10/2009-date)

Publications

  1. Tummala, K. S. and Djouder, N. (2015). [14C]-tryptophan metabolic tracing in liver cancer cells. Bio-protocol 5(17): e1582.
  2. Tummala, K. S. and Djouder, N. (2015). Oncogene-induced NAD(+) depletion in tumorigenesis. Oncoscience 2(4): 318-319.
  3. Djouder, N. (2015). Boosting NAD+ for the prevention and treatment of liver cancer. Molecular & Cellular Oncology(just-accepted): 00-00.
  4. Fawal, M. A., Brandt, M. and Djouder, N. (2015). MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation. Dev Cell 33(1): 67-81.
  5. Tummala, K. S., Gomes, A. L., Yilmaz, M., Grana, O., Bakiri, L., Ruppen, I., Ximenez-Embun, P., Sheshappanavar, V., Rodriguez-Justo, M., Pisano, D. G., Wagner, E. F. and Djouder, N. (2014). Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage. Cancer Cell 26(6): 826-839.
  6. Mita, P., Savas, J. N., Ha, S., Djouder, N., Yates, J. R., 3rd and Logan, S. K. (2013). Analysis of URI nuclear interaction with RPB5 and components of the R2TP/prefoldin-like complex. PLoS One 8(5): e63879.
  7. Mita, P., Savas, J. N., Djouder, N., Yates, J. R., 3rd, Ha, S., Ruoff, R., Schafler, E. D., Nwachukwu, J. C., Tanese, N., Cowan, N. J., Zavadil, J., Garabedian, M. J. and Logan, S. K. (2011). Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP. Mol Cell Biol 31(17): 3639-3652.
  8. Theurillat, J. P., Metzler, S. C., Henzi, N., Djouder, N., Helbling, M., Zimmermann, A. K., Jacob, F., Soltermann, A., Caduff, R., Heinzelmann-Schwarz, V., Moch, H. and Krek, W. (2011). URI is an oncogene amplified in ovarian cancer cells and is required for their survival. Cancer Cell 19(3): 317-332.
  9. Djouder, N., Tuerk, R. D., Suter, M., Salvioni, P., Thali, R. F., Scholz, R., Vaahtomeri, K., Auchli, Y., Rechsteiner, H., Brunisholz, R. A., Viollet, B., Makela, T. P., Wallimann, T., Neumann, D. and Krek, W. (2010). PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis. EMBO J 29(2): 469-481.
  10. Djouder, N., Metzler, S. C., Schmidt, A., Wirbelauer, C., Gstaiger, M., Aebersold, R., Hess, D. and Krek, W. (2007). S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. Mol Cell 28(1): 28-40.
  11. Djouder, N., Aneiros, E., Cavalie, A. and Aktories, K. (2003). Effects of large clostridial cytotoxins on activation of RBL 2H3-hm1 mast cells indicate common and different roles of Rac in FcepsilonRI and M1-receptor signaling. J Pharmacol Exp Ther 304(3): 1243-1250.
  12. Djouder, N., Schmidt, G., Frings, M., Cavalie, A., Thelen, M. and Aktories, K. (2001). Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells. J Immunol 166(3): 1627-1634.
  13. Busch, C., Orth, J., Djouder, N. and Aktories, K. (2001). Biological activity of a C-terminal fragment of Pasteurella multocida toxin. Infect Immun 69(6): 3628-3634.
  14. Walev, I., Bhakdi, S. C., Hofmann, F., Djonder, N., Valeva, A., Aktories, K. and Bhakdi, S. (2001). Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O. Proceedings of the National Academy of Sciences 98(6): 3185-3190.
  15. Djouder, N., Prepens, U., Aktories, K. and Cavalie, A. (2000). Inhibition of calcium release-activated calcium current by Rac/Cdc42-inactivating clostridial cytotoxins in RBL cells. J Biol Chem 275(25): 18732-18738.
  16. Ellmerich, S., Djouder, N., Scholler, M. and Klein, J. P. (2000). Production of cytokines by monocytes, epithelial and endothelial cells activated by Streptococcus bovis. Cytokine 12(1): 26-31.
Protocols by Nabil Djouder
  1. [14C]-Tryptophan Metabolic Tracing in Liver Cancer Cells