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Rainer Melzer


Dr. rer. nat. (Ph.D. equivalent) in Genetics, “summa cum laude” (equivalent to “with distinction”), Department of Genetics, Friedrich Schiller University Jena, 2009

Current position

Lecturer for Molecular Genetics, School of Biology and Environmental Science, University College Dublin (since 01/2015)


Google scholar: http://scholar.google.de/citations?user=&user=4DI9mrIAAAAJ

  1. Theißen, G. and Melzer, R. (2016). Robust views on plasticity and biodiversity. Ann Bot 117, 693-697.
  2. Melzer, R. and Theissen, G. (2016). The significance of developmental robustness for species diversity. Ann Bot. (Epub ahead of print)
  3. Rumpler, F., Gramzow, L., Theissen, G. and Melzer, R. (2015). Did convergent protein evolution enable phytoplasmas to generate 'zombie plants'? Trends Plant Sci 20(12): 798-806.
  4.  Rümpler, F., Theißen, G. and Melzer, R. (2015). Character-state reconstruction to infer ancestral protein-protein interaction patterns. Bio-protocol 5(16): e1566.    
  5. Melzer, R.*, Härter, A.*, Rümpler, F., Kim, S., Soltis, P. S., Soltis, D. E. and Theissen, G. (2014). DEF- and GLO-like proteins may have lost most of their interaction partners during angiosperm evolution. Ann Bot 114(7): 1431-1443. (*Equally contributing authors)
  6. Puranik, S., Acajjaoui, S., Conn, S., Costa, L., Conn, V., Vial, A., Marcellin, R., Melzer, R., Brown, E., Hart, D., Theissen, G., Silva, C. S., Parcy, F., Dumas, R., Nanao, M. and Zubieta, C. (2014). Structural basis for the oligomerization of the MADS domain transcription factor SEPALLATA3 in Arabidopsis. Plant Cell 26(9): 3603-3615.
  7. Jetha, K., Theissen, G. and Melzer, R. (2014). Arabidopsis SEPALLATA proteins differ in cooperative DNA-binding during the formation of floral quartet-like complexes. Nucleic Acids Res 42(17): 10927-10942.
  8. Theißen, G. and Melzer, R. (2013). Flower development, Genetics of. In: Maloy, S. and Hughes, K. (ed). Brenner’s Encyclopedia of Genetics. 2nd edition.
  9. Lange, M., Orashakova, S., Lange, S., Melzer, R., Theissen, G., Smyth, D. R. and Becker, A. (2013). The seirena B class floral homeotic mutant of California Poppy (Eschscholzia californica) reveals a function of the enigmatic PI motif in the formation of specific multimeric MADS domain protein complexes. Plant Cell 25(2): 438-453.
  10. Galimba, K. D., Tolkin, T. R., Sullivan, A. M., Melzer, R., Theissen, G. and Di Stilio, V. S. (2012). Loss of deeply conserved C-class floral homeotic gene function and C- and E-class protein interaction in a double-flowered ranunculid mutant. Proc Natl Acad Sci U S A 109(34): E2267-2275.
  11. Wang, Y. Q., Melzer, R. and Theissen, G. (2011). A double-flowered variety of lesser periwinkle (Vinca minor fl. pl.) that has persisted in the wild for more than 160 years. Ann Bot 107(9): 1445-1452.
  12. Melzer, R. and Theissen, G. (2011). MADS and more: transcription factors that shape the plant. Methods Mol Biol 754: 3-18.
  13. Wang, Y. Q.*, Melzer, R.* and Theissen, G. (2010). Molecular interactions of orthologues of floral homeotic proteins from the gymnosperm Gnetum gnemon provide a clue to the evolutionary origin of 'floral quartets'. Plant J 64(2): 177-190. (*Equally contributing authors)
  14. Erdmann, R., Gramzow, L., Melzer, R., Theissen, G. and Becker, A. (2010). GORDITA (AGL63) is a young paralog of the Arabidopsis thaliana B(sister) MADS box gene ABS (TT16) that has undergone neofunctionalization. Plant J 63(6): 914-924.
  15. Melzer, R., Wang, Y. Q. and Theissen, G. (2010). The naked and the dead: the ABCs of gymnosperm reproduction and the origin of the angiosperm flower. Semin Cell Dev Biol 21(1): 118-128.
  16. Melzer, R. and Theissen, G. (2009). Reconstitution of 'floral quartets' in vitro involving class B and class E floral homeotic proteins. Nucleic Acids Res 37(8): 2723-2736.
  17. Melzer, R., Verelst, W. and Theissen, G. (2009). The class E floral homeotic protein SEPALLATA3 is sufficient to loop DNA in 'floral quartet'-like complexes in vitro. Nucleic Acids Res 37(1): 144-157.
  18. Theissen, G. and Melzer, R. (2007). Molecular mechanisms underlying origin and diversification of the angiosperm flower. Ann Bot 100(3): 603-619.
  19. Melzer, R., Kaufmann, K. and Theißen, G. (2006). Missing links: DNA-binding and target gene specificity of floral homeotic proteins. Advances in Botanical Research Incorporating Advances in Plant Pathology 44: 209-236.
  20. Theißen G. and Melzer R. (2006). Combinatorial control of floral organ identity by MADS-domain transcription factors. In: Grasser, K. (ed). Regulation of transcription in plants. Annual Plant Reviews 29: 253-265.
  21. Kaufmann, K., Melzer, R. and Theissen, G. (2005). MIKC-type MADS-domain proteins: structural modularity, protein interactions and network evolution in land plants. Gene 347(2): 183-198.

Protocols by Rainer Melzer
  1. Character-State Reconstruction to Infer Ancestral Protein-Protein Interaction Patterns