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Mark Shlomchik


M.D., Ph.D., School of Medicine and Graduate, School of Arts and Science (Immunology Graduate Group), University of Pennsylvania, 1989

Current position

Professor and Chair, Department of Immunology, University of Pittsburgh School of Medicine (07/2013-present)

Publications (since 2005)

Original articles

  1. Di Niro, R., Snir, O., Kaukinen, K., Yaari, G., Lundin, K. E., Gupta, N. T., Kleinstein, S. H., Cols, M., Cerutti, A., Maki, M., Shlomchik, M. J. and Sollid, L. M. (2015). Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease. Mucosal Immunol. (Epub ahead of print)
  2. Teichmann, L. L., Cullen, J. L., Kashgarian, M., Dong, C., Craft, J. and Shlomchik, M. J. (2015). Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus. Immunity 42(3): 552-565.
  3. Wieland, A., Shashidharamurthy, R., Kamphorst, A. O., Han, J. H., Aubert, R. D., Choudhury, B. P., Stowell, S. R., Lee, J., Punkosdy, G. A., Shlomchik, M. J., Selvaraj, P. and Ahmed, R. (2015). Antibody effector functions mediated by Fcgamma-receptors are compromised during persistent viral infection. Immunity 42(2): 367-378.
  4. Sharma, S., Campbell, A. M., Chan, J., Schattgen, S. A., Orlowski, G. M., Nayar, R., Huyler, A. H., Nundel, K., Mohan, C., Berg, L. J., Shlomchik, M. J., Marshak-Rothstein, A. and Fitzgerald, K. A. (2015). Suppression of systemic autoimmunity by the innate immune adaptor STING. Proc Natl Acad Sci U S A 112(7): E710-717.
  5. Sang, A., Niu, H., Cullen, J., Choi, S. C., Zheng, Y. Y., Wang, H., Shlomchik, M. J. and Morel, L. (2014). Activation of rheumatoid factor-specific B cells is antigen dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse model. J Immunol 193(4): 1609-1621.
  6. Chappell, C. P., Giltiay, N. V., Draves, K. E., Chen, C., Hayden-Ledbetter, M. S., Shlomchik, M. J., Kaplan, D. H. and Clark, E. A. (2014). Targeting antigens through blood dendritic cell antigen 2 on plasmacytoid dendritic cells promotes immunologic tolerance. J Immunol 192(12): 5789-5801.
  7. Conter, L. J., Song, E., Shlomchik, M. J. and Tomayko, M. M. (2014). CD73 expression is dynamically regulated in the germinal center and bone marrow plasma cells are diminished in its absence. PLoS One 9(3): e92009.
  8. Uduman, M., Shlomchik, M. J., Vigneault, F., Church, G. M. and Kleinstein, S. H. (2014). Integrating B cell lineage information into statistical tests for detecting selection in Ig sequences. J Immunol 192(3): 867-874.
  9. Zuccarino-Catania, G. V., Sadanand, S., Weisel, F. J., Tomayko, M. M., Meng, H., Kleinstein, S. H., Good-Jacobson, K. L. and Shlomchik, M. J. (2014). CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype. Nat Immunol 15(7): 631-637.
  10. Simonetti, G., Carette, A., Silva, K., Wang, H., De Silva, N. S., Heise, N., Siebel, C. W., Shlomchik, M. J. and Klein, U. (2013). IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity. J Exp Med 210(13): 2887-2902.
  11. Molnarfi, N., Schulze-Topphoff, U., Weber, M. S., Patarroyo, J. C., Prod'homme, T., Varrin-Doyer, M., Shetty, A., Linington, C., Slavin, A. J., Hidalgo, J., Jenne, D. E., Wekerle, H., Sobel, R. A., Bernard, C. C., Shlomchik, M. J. and Zamvil, S. S. (2013). MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J Exp Med 210(13): 2921-2937.
  12. Jellusova, J., Miletic, A. V., Cato, M. H., Lin, W. W., Hu, Y., Bishop, G. A., Shlomchik, M. J. and Rickert, R. C. (2013). Context-specific BAFF-R signaling by the NF-kappaB and PI3K pathways. Cell Rep 5(4): 1022-1035.
  13. Giltiay, N. V., Lu, Y., Cullen, J. L., Jorgensen, T. N., Shlomchik, M. J. and Li, X. (2013). Spontaneous loss of tolerance of autoreactive B cells in Act1-deficient rheumatoid factor transgenic mice. J Immunol 191(5): 2155-2163.
  14. Duke, J. L., Liu, M., Yaari, G., Khalil, A. M., Tomayko, M. M., Shlomchik, M. J., Schatz, D. G. and Kleinstein, S. H. (2013). Multiple transcription factor binding sites predict AID targeting in non-Ig genes. J Immunol 190(8): 3878-3888.
  15. Nickerson, K. M., Cullen, J. L., Kashgarian, M. and Shlomchik, M. J. (2013). Exacerbated autoimmunity in the absence of TLR9 in MRL.Fas(lpr) mice depends on Ifnar1. J Immunol 190(8): 3889-3894. (Featured article)
  16. Sweet, R. A., Cullen, J. L. and Shlomchik, M. J. (2013). Rheumatoid factor B cell memory leads to rapid, switched antibody-forming cell responses. J Immunol 190(5): 1974-1981.
  17. Teichmann, L. L., Schenten, D., Medzhitov, R., Kashgarian, M. and Shlomchik, M. J. (2013). Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity 38(3): 528-540.
  18. Nickerson, K. M., Christensen, S. R., Cullen, J. L., Meng, W., Luning Prak, E. T. and Shlomchik, M. J. (2013). TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation. J Immunol 190(4): 1447-1456.
  19. Nanton, M. R., Way, S. S., Shlomchik, M. J. and McSorley, S. J. (2012). Cutting edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion. J Immunol 189(12): 5503-5507.
  20. Campbell, A. M., Kashgarian, M. and Shlomchik, M. J. (2012). NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus. Sci Transl Med 4(157): 157ra141.
  21. Khalil, A. M., Cambier, J. C. and Shlomchik, M. J. (2012). B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Science 336(6085): 1178-1181.
  22. Good-Jacobson, K. L., Song, E., Anderson, S., Sharpe, A. H. and Shlomchik, M. J. (2012). CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation. J Immunol 188(9): 4217-4225.
  23. Srinivasan, M., Flynn, R., Price, A., Ranger, A., Browning, J. L., Taylor, P. A., Ritz, J., Antin, J. H., Murphy, W. J., Luznik, L., Shlomchik, M. J., Panoskaltsis-Mortari, A. and Blazar, B. R. (2012). Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. Blood 119(6): 1570-1580.
  24. Modi, B. G., Neustadter, J., Binda, E., Lewis, J., Filler, R. B., Roberts, S. J., Kwong, B. Y., Reddy, S., Overton, J. D., Galan, A., Tigelaar, R., Cai, L., Fu, P., Shlomchik, M., Kaplan, D. H., Hayday, A. and Girardi, M. (2012). Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma. Science 335(6064): 104-108.
  25. Teichmann, L. L., Kashgarian, M., Weaver, C. T., Roers, A., Muller, W. and Shlomchik, M. J. (2012). B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice. J Immunol 188(2): 678-685.
  26. Shlomchik, M. J. and Weisel, F. (2012). Germinal centers. Immunol Rev 247(1): 5-10.
  27. Shlomchik, M. J. and Weisel, F. (2012). Germinal center selection and the development of memory B and plasma cells. Immunol Rev 247(1): 52-63.
  28. Juchem, K. W., Anderson, B. E., Zhang, C., McNiff, J. M., Demetris, A. J., Farber, D. L., Caton, A. J., Shlomchik, W. D. and Shlomchik, M. J. (2011). A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells. Blood 118(23): 6209-6219.
  29. Ahuja, A., Teichmann, L. L., Wang, H., Dunn, R., Kehry, M. R. and Shlomchik, M. J. (2011). An acquired defect in IgG-dependent phagocytosis explains the impairment in antibody-mediated cellular depletion in Lupus. J Immunol 187(7): 3888-3894.
  30. Anderson, B. E., Tang, A. L., Wang, Y., Froicu, M., Rothstein, D., McNiff, J. M., Jain, D., Demetris, A. J., Farber, D. L., Shlomchik, W. D. and Shlomchik, M. J. (2011). Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4(+) effector memory T cells. Eur J Immunol 41(9): 2782-2792.
  31. Sweet, R. A., Ols, M. L., Cullen, J. L., Milam, A. V., Yagita, H. and Shlomchik, M. J. (2011). Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo. Proc Natl Acad Sci U S A 108(19): 7932-7937.
  32. Monson, N. L., Cravens, P., Hussain, R., Harp, C. T., Cummings, M., de Pilar Martin, M., Ben, L. H., Do, J., Lyons, J. A., Lovette-Racke, A., Cross, A. H., Racke, M. K., Stuve, O., Shlomchik, M. and Eagar, T. N. (2011). Rituximab therapy reduces organ-specific T cell responses and ameliorates experimental autoimmune encephalomyelitis. PLoS One 6(2): e17103.
  33. Li, H., Kaplan, D. H., Matte-Martone, C., Tan, H. S., Venkatesan, S., Johnson, K., Demetris, A. J., McNiff, J., Shlomchik, M. J. and Shlomchik, W. D. (2011). Langerhans cells are not required for graft-versus-host disease. Blood 117(2): 697-707.
  34. Teichmann, L. L., Ols, M. L., Kashgarian, M., Reizis, B., Kaplan, D. H. and Shlomchik, M. J. (2010). Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage. Immunity 33(6): 967-978.
  35. Tomayko, M. M., Steinel, N. C., Anderson, S. M. and Shlomchik, M. J. (2010). Cutting edge: Hierarchy of maturity of murine memory B cell subsets. J Immunol 185(12): 7146-7150.
  36. Matte-Martone, C., Wang, X., Anderson, B., Jain, D., Demetris, A. J., McNiff, J., Shlomchik, M. J. and Shlomchik, W. D. (2010). Recipient B cells are not required for graft-versus-host disease induction. Biol Blood Marrow Transplant 16(9): 1222-1230.
  37. Sweet, R. A., Christensen, S. R., Harris, M. L., Shupe, J., Sutherland, J. L. and Shlomchik, M. J. (2010). A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formation. Autoimmunity 43(8): 607-618.
  38. Herbst, R., Wang, Y., Gallagher, S., Mittereder, N., Kuta, E., Damschroder, M., Woods, R., Rowe, D. C., Cheng, L., Cook, K., Evans, K., Sims, G. P., Pfarr, D. S., Bowen, M. A., Dall'Acqua, W., Shlomchik, M., Tedder, T. F., Kiener, P., Jallal, B., Wu, H. and Coyle, A. J. (2010). B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody. J Pharmacol Exp Ther 335(1): 213-222.
  39. Avalos, A. M., Kiefer, K., Tian, J., Christensen, S., Shlomchik, M., Coyle, A. J. and Marshak-Rothstein, A. (2010). RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes. Autoimmunity 43(1): 103-110.
  40. Good-Jacobson, K. L. and Shlomchik, M. J. (2010). Plasticity and heterogeneity in the generation of memory B cells and long-lived plasma cells: the influence of germinal center interactions and dynamics. J Immunol 185(6): 3117-3125.
  41. Good-Jacobson, K. L., Szumilas, C. G., Chen, L., Sharpe, A. H., Tomayko, M. M. and Shlomchik, M. J. (2010). PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol 11(6): 535-542.
  42. Damdinsuren, B., Zhang, Y., Khalil, A., Wood, W. H., 3rd, Becker, K. G., Shlomchik, M. J. and Sen, R. (2010). Single round of antigen receptor signaling programs naive B cells to receive T cell help. Immunity 32(3): 355-366.
  43. Nickerson, K. M., Christensen, S. R., Shupe, J., Kashgarian, M., Kim, D., Elkon, K. and Shlomchik, M. J. (2010). TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus. J Immunol 184(4): 1840-1848.
  44. James, S. E., Orgun, N. N., Tedder, T. F., Shlomchik, M. J., Jensen, M. C., Lin, Y., Greenberg, P. D. and Press, O. W. (2009). Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice. Blood 114(27): 5454-5463.
  45. Anderson, S. M., Khalil, A., Uduman, M., Hershberg, U., Louzoun, Y., Haberman, A. M., Kleinstein, S. H. and Shlomchik, M. J. (2009). Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells. J Immunol 183(11): 7314-7325.
  46. Hamilton-Williams, E. E., Martinez, X., Clark, J., Howlett, S., Hunter, K. M., Rainbow, D. B., Wen, L., Shlomchik, M. J., Katz, J. D., Beilhack, G. F., Wicker, L. S. and Sherman, L. A. (2009). Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice. J Immunol 183(3): 1533-1541.
  47. Shlomchik, M. J. (2009). Activating systemic autoimmunity: B's, T's, and tolls. Curr Opin Immunol 21(6): 626-633.
  48. Green, N. M., Laws, A., Kiefer, K., Busconi, L., Kim, Y. M., Brinkmann, M. M., Trail, E. H., Yasuda, K., Christensen, S. R., Shlomchik, M. J., Vogel, S., Connor, J. H., Ploegh, H., Eilat, D., Rifkin, I. R., van Seventer, J. M. and Marshak-Rothstein, A. (2009). Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol 183(3): 1569-1576.
  49. Cole, L. E., Yang, Y., Elkins, K. L., Fernandez, E. T., Qureshi, N., Shlomchik, M. J., Herzenberg, L. A., Herzenberg, L. A. and Vogel, S. N. (2009). Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge. Proc Natl Acad Sci U S A 106(11): 4343-4348.
  50. Vesely, D. L., Fish, D., Shlomchik, M. J., Kaplan, D. H. and Bockenstedt, L. K. (2009). Langerhans cell deficiency impairs Ixodes scapularis suppression of Th1 responses in mice. Infect Immun 77(5): 1881-1887.
  51. Blair, P. A., Chavez-Rueda, K. A., Evans, J. G., Shlomchik, M. J., Eddaoudi, A., Isenberg, D. A., Ehrenstein, M. R. and Mauri, C. (2009). Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice. J Immunol 182(6): 3492-3502.
  52. Whitmire, J. K., Asano, M. S., Kaech, S. M., Sarkar, S., Hannum, L. G., Shlomchik, M. J. and Ahmed, R. (2009). Requirement of B cells for generating CD4+ T cell memory. J Immunol 182(4): 1868-1876.
  53. Beers, S. A., Chan, C. H., James, S., French, R. R., Attfield, K. E., Brennan, C. M., Ahuja, A., Shlomchik, M. J., Cragg, M. S. and Glennie, M. J. (2008). Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation. Blood 112(10): 4170-4177.
  54. Uccellini, M. B., Busconi, L., Green, N. M., Busto, P., Christensen, S. R., Shlomchik, M. J., Marshak-Rothstein, A. and Viglianti, G. A. (2008). Autoreactive B cells discriminate CpG-rich and CpG-poor DNA and this response is modulated by IFN-alpha. J Immunol 181(9): 5875-5884.
  55. Shlomchik, M. J. (2008). Sites and stages of autoreactive B cell activation and regulation. Immunity 28(1): 18-28.
  56. Scholz, J. L., Crowley, J. E., Tomayko, M. M., Steinel, N., O'Neill, P. J., Quinn, W. J., 3rd, Goenka, R., Miller, J. P., Cho, Y. H., Long, V., Ward, C., Migone, T. S., Shlomchik, M. J. and Cancro, M. P. (2008). BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proc Natl Acad Sci U S A 105(40): 15517-15522.
  57. Obhrai, J. S., Oberbarnscheidt, M., Zhang, N., Mueller, D. L., Shlomchik, W. D., Lakkis, F. G., Shlomchik, M. J. and Kaplan, D. H. (2008). Langerhans cells are not required for efficient skin graft rejection. J Invest Dermatol 128(8): 1950-1955.
  58. Herlands, R. A., Christensen, S. R., Sweet, R. A., Hershberg, U. and Shlomchik, M. J. (2008). T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells. Immunity 29(2): 249-260.
  59. Tomayko, M. M., Anderson, S. M., Brayton, C. E., Sadanand, S., Steinel, N. C., Behrens, T. W. and Shlomchik, M. J. (2008). Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities. J Immunol 181(1): 27-38.
  60. Anderson, B. E., Taylor, P. A., McNiff, J. M., Jain, D., Demetris, A. J., Panoskaltsis-Mortari, A., Ager, A., Blazar, B. R., Shlomchik, W. D. and Shlomchik, M. J. (2008). Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 111(10): 5242-5251.
  61. Ahuja, A., Anderson, S. M., Khalil, A. and Shlomchik, M. J. (2008). Maintenance of the plasma cell pool is independent of memory B cells. Proc Natl Acad Sci U S A 105(12): 4802-4807.
  62. Panoskaltsis-Mortari, A., Taylor, P. A., Riddle, M. J., Shlomchik, M. A. and Blazar, B. R. (2008). In situ identification of allospecific B cells using pentamers. Blood 111(7): 3904-3905.
  63. Hershberg, U., Uduman, M., Shlomchik, M. J. and Kleinstein, S. H. (2008). Improved methods for detecting selection by mutation analysis of Ig V region sequences. Int Immunol 20(5): 683-694.
  64. Hu, C. Y., Rodriguez-Pinto, D., Du, W., Ahuja, A., Henegariu, O., Wong, F. S., Shlomchik, M. J. and Wen, L. (2007). Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J Clin Invest 117(12): 3857-3867.
  65. Kaplan, D. H., Li, M. O., Jenison, M. C., Shlomchik, W. D., Flavell, R. A. and Shlomchik, M. J. (2007). Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J Exp Med 204(11): 2545-2552.
  66. Herlands, R. A., William, J., Hershberg, U. and Shlomchik, M. J. (2007). Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites. Eur J Immunol 37(12): 3339-3351.
  67. Harvey, B. P., Gee, R. J., Haberman, A. M., Shlomchik, M. J. and Mamula, M. J. (2007). Antigen presentation and transfer between B cells and macrophages. Eur J Immunol 37(7): 1739-1751.
  68. Ahuja, A., Shupe, J., Dunn, R., Kashgarian, M., Kehry, M. R. and Shlomchik, M. J. (2007). Depletion of B cells in murine lupus: efficacy and resistance. J Immunol 179(5): 3351-3361.
  69. Anderson, S. M., Tomayko, M. M., Ahuja, A., Haberman, A. M. and Shlomchik, M. J. (2007). New markers for murine memory B cells that define mutated and unmutated subsets. J Exp Med 204(9): 2103-2114.
  70. Deng, S., Moore, D. J., Huang, X., Lian, M. M., Mohiuddin, M., Velededeoglu, E., Lee, M. K. t., Sonawane, S., Kim, J., Wang, J., Chen, H., Corfe, S. A., Paige, C., Shlomchik, M., Caton, A. and Markmann, J. F. (2007). Cutting edge: transplant tolerance induced by anti-CD45RB requires B lymphocytes. J Immunol 178(10): 6028-6032.
  71. Hauser, A. E., Junt, T., Mempel, T. R., Sneddon, M. W., Kleinstein, S. H., Henrickson, S. E., von Andrian, U. H., Shlomchik, M. J. and Haberman, A. M. (2007). Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity 26(5): 655-667.
  72. Hauser, A. E., Shlomchik, M. J. and Haberman, A. M. (2007). In vivo imaging studies shed light on germinal-centre development. Nat Rev Immunol 7(7): 499-504.
  73. Christensen, S. R. and Shlomchik, M. J. (2007). Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors. Semin Immunol 19(1): 11-23.
  74. Hershberg, U. and Shlomchik, M. J. (2006). Differences in potential for amino acid change after mutation reveals distinct strategies for kappa and lambda light-chain variation. Proc Natl Acad Sci U S A 103(43): 15963-15968.
  75. Anderson, S. M., Tomayko, M. M. and Shlomchik, M. J. (2006). Intrinsic properties of human and murine memory B cells. Immunol Rev 211: 280-294.
  76. Yan, J., Harvey, B. P., Gee, R. J., Shlomchik, M. J. and Mamula, M. J. (2006). B cells drive early T cell autoimmunity in vivo prior to dendritic cell-mediated autoantigen presentation. J Immunol 177(7): 4481-4487.
  77. Rossbacher, J., Haberman, A. M., Neschen, S., Khalil, A. and Shlomchik, M. J. (2006). Antibody-independent B cell-intrinsic and -extrinsic roles for CD21/35. Eur J Immunol 36(9): 2384-2393.
  78. Beaudette-Zlatanova, B. C., Ling, T., Shlomchik, M. J., Marshak-Rothstein, A. and Rifkin, I. R. (2006). B cells and dendritic cells from V kappa 8 light chain transgenic mice activate MRL-lpr/gld CD4+ T cells. J Immunol 177(1): 45-52.
  79. William, J., Euler, C., Primarolo, N. and Shlomchik, M. J. (2006). B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation. J Immunol 176(4): 2142-2151.
  80. Christensen, S. R., Shupe, J., Nickerson, K., Kashgarian, M., Flavell, R. A. and Shlomchik, M. J. (2006). TLR7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25:417-428.
  81. Anderson, S. M., Hannum, L. G. and Shlomchik, M. J. (2006). Memory B cell survival and function in the absence of secreted antibody and immune complexes on follicular dendritic cells. J Immunol 176(8): 4515-4519.
  82. Kaplan, D. H., Jenison, M. C., Saeland, S., Shlomchik, W. D. and Shlomchik, M. J. (2005). Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 23(6): 611-620.
  83. Novobrantseva, T. I., Majeau, G. R., Amatucci, A., Kogan, S., Brenner, I., Casola, S., Shlomchik, M. J., Koteliansky, V., Hochman, P. S. and Ibraghimov, A. (2005). Attenuated liver fibrosis in the absence of B cells. J Clin Invest 115(11): 3072-3082.
  84. Lau, C. M., Broughton, C., Tabor, A. S., Akira, S., Flavell, R. A., Mamula, M. J., Christensen, S. R., Shlomchik, M. J., Viglianti, G. A., Rifkin, I. R. and Marshak-Rothstein, A. (2005). RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med 202(9): 1171-1177.
  85. Odegard, V. H., Kim, S. T., Anderson, S. M., Shlomchik, M. J. and Schatz, D. G. (2005). Histone modifications associated with somatic hypermutation. Immunity 23(1): 101-110.
  86. Christensen, S. R., Kashgarian, M., Alexopoulou, L., Flavell, R. A., Akira, S. and Shlomchik, M. J. (2005). Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med 202(2): 321-331.
  87. William, J., Euler, C., Leadbetter, E., Marshak-Rothstein, A. and Shlomchik, M. J. (2005). Visualizing the onset and evolution of an autoantibody response in systemic autoimmunity. J Immunol 174(11): 6872-6878.
  88. William, J., Euler, C. and Shlomchik, M. J. (2005). Short-lived plasmablasts dominate the early spontaneous rheumatoid factor response: differentiation pathways, hypermutating cell types, and affinity maturation outside the germinal center. J Immunol 174(11): 6879-6887.
  89. O'Neill, S. K., Shlomchik, M. J., Glant, T. T., Cao, Y., Doodes, P. D. and Finnegan, A. (2005). Antigen-specific B cells are required as APCs and autoantibody-producing cells for induction of severe autoimmune arthritis. J Immunol 174(6): 3781-3788.
  90. Anderson, B. E., McNiff, J. M., Jain, D., Blazar, B. R., Shlomchik, W. D. and Shlomchik, M. J. (2005). Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood 105(5): 2227-2234. (MJS and WDS are co-senior authors)

Protocols by Mark Shlomchik
  1. Adoptive Transfer of Memory B Cells