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Alessandra Sacco

Education

Ph.D. in Molecular Biology, Universita’ La Sapienza, Rome, 1997

Current position

Associate Professor in Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA

Publications

  1. Kang, Y., Tierney, M., Ong, E., Zhang, L., Piermarocchi, C., Sacco, A. and Paternostro, G. (2015). Combinations of kinase inhibitors protecting myoblasts against hypoxia. PLoS One 10(6): e0126718.
  2. Tierney, M. T.*, Aydogdu, T.*, Sala, D., Malecova, B., Gatto, S., Puri, P. L., Latella, L. and Sacco, A. (2014). STAT3 signaling controls satellite cell expansion and skeletal muscle repair. Nat Med 20(10): 1182-1186. (*These authors equally contributed to this work)
  3. Chakkalakal, J. V., Christensen, J., Xiang, W., Tierney, M. T., Boscolo, F. S., Sacco, A. and Brack, A. S. (2014). Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state. Development 141(8): 1649-1659.
  4. Gokhin, D. S., Tierney, M. T., Sui, Z., Sacco, A. and Fowler, V. M. (2014). Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle. Mol Biol Cell 25(6): 852-865.
  5. Hwang, Y., Suk, S., Lin, S., Tierney, M., Du, B., Seo, T., Mitchell, A., Sacco, A. and Varghese, S. (2013). Directed in vitro myogenesis of human embryonic stem cells and their in vivo engraftment. PLoS One 8(8): e72023.
  6. Mozzetta, C., Consalvi, S., Saccone, V., Tierney, M., Diamantini, A., Mitchell, K. J., Marazzi, G., Borsellino, G., Battistini, L., Sassoon, D., Sacco, A. and Puri, P. L. (2013). Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice. EMBO Mol Med 5(4): 626-639.
  7. Arnold, C. P., Tan, R., Zhou, B., Yue, S. B., Schaffert, S., Biggs, J. R., Doyonnas, R., Lo, M. C., Perry, J. M., Renault, V. M., Sacco, A., Somervaille, T., Viatour, P., Brunet, A., Cleary, M. L., Li, L., Sage, J., Zhang, D. E., Blau, H. M., Chen, C. and Chen, C. Z. (2011). MicroRNA programs in normal and aberrant stem and progenitor cells. Genome Res 21(5): 798-810.
  8. Sacco, A.*, Mourkioti, F.*, Tran, R., Choi, J., Llewellyn, M., Kraft, P., Shkreli, M., Delp, S., Pomerantz, J. H., Artandi, S. E. and Blau, H. M. (2010). Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice. Cell 143(7): 1059-1071. (*These authors equally contributed to this work)
  9. Gilbert, P. M., Havenstrite, K. L., Magnusson, K. E., Sacco, A., Leonardi, N. A., Kraft, P., Nguyen, N. K., Thrun, S., Lutolf, M. P. and Blau, H. M. (2010). Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture. Science 329(5995): 1078-1081.
  10. Bhutani, N., Brady, J. J., Damian, M., Sacco, A., Corbel, S. Y. and Blau, H. M. (2010). Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature 463(7284): 1042-1047.
  11. Cosgrove, B. D., Sacco, A., Gilbert, P. M. and Blau, H. M. (2009). A home away from home: challenges and opportunities in engineering in vitro muscle satellite cell niches. Differentiation 78(2-3): 185-194.
  12. Sacco, A., Doyonnas, R., Kraft, P., Vitorovic, S. and Blau, H. M. (2008). Self-renewal and expansion of single transplanted muscle stem cells. Nature 456(7221): 502-506.
  13. Sacco, A., Doyonnas, R., LaBarge, M. A., Hammer, M. M., Kraft, P. and Blau, H. M. (2005). IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursors. J Cell Biol 171(3): 483-492.
  14. Doyonnas, R., LaBarge, M. A., Sacco, A., Charlton, C. and Blau, H. M. (2004). Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors. Proc Natl Acad Sci U S A 101(37): 13507-13512.
  15. Amadoro, G., Serafino, A. L., Barbato, C., Ciotti, M. T., Sacco, A., Calissano, P. and Canu, N. (2004). Role of N-terminal tau domain integrity on the survival of cerebellar granule neurons. Cell Death Differ 11(2): 217-230.
  16. Sacco, A., Siepi, F. and Crescenzi, M. (2003). HPV E7 expression in skeletal muscle cells distinguishes initiation of the postmitotic state from its maintenance. Oncogene 22(26): 4027-4034.
  17. Bonapace, I. M., Latella, L., Papait, R., Nicassio, F., Sacco, A., Muto, M., Crescenzi, M. and Di Fiore, P. P. (2002). Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry. J Cell Biol 157(6): 909-914.
  18. Latella, L.*, Sacco, A.*, Pajalunga, D., Tiainen, M., Macera, D., D'Angelo, M., Felici, A., Sacchi, A. and Crescenzi, M. (2001). Reconstitution of cyclin D1-associated kinase activity drives terminally differentiated cells into the cell cycle. Mol Cell Biol 21(16): 5631-5643. (*These two authors equally contributed to this work)
  19. Soucek, L., Helmer-Citterich, M., Sacco, A., Jucker, R., Cesareni, G. and Nasi, S. (1998). Design and properties of a Myc derivative that efficiently homodimerizes. Oncogene 17(19): 2463-2472.

Book chapters, reviews etc.

  1. Sacco, A., Gilbert, P. and Helen, M. B. (2008). Chapter: Skeletal muscle stem cells”. In: Essentials of Stem Cell Biology. Elsevier Publisher, 249-257.
  2. Sacco, A., Gilbert, P. and Helen, M. B. (2008). Stem cell self-renewal. In: Stem Cells Encyclopedia. SAGE Publisher.
  3. Sacco, A., Pajalunga, D., Latella, L., Siepi, F., Rufini, A. and Marco, C. (2001). Cell cycle reactivation in skeletal muscle and other terminally differentiated cells. In: Marco, C. (ed). Reactivation of the cell cycle in terminally differentiated cells. Georgetown: Eureka.com publishers, 44-58.
Protocols by Alessandra Sacco
  1. FACS-based Satellite Cell Isolation From Mouse Hind Limb Muscles