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Flávio V. Loures

Education

Ph.D. in Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo

Current position

Young Investigator, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo

Publications

  1. Loures, F. V., Araujo, E. F., Feriotti, C., Bazan, S. B. and Calich, V. L. (2015). TLR-4 cooperates with Dectin-1 and mannose receptor to expand Th17 and Tc17 cells induced by Paracoccidioides brasiliensis stimulated dendritic cells. Front Microbiol 6: 261.
  2. Loures, F. V., R öhm, M., Lee, C. K., Santos, E., Wang, J. P., Specht, C. A., Calich, V. L., Urban, C. F. and Levitz, S. M. (2015). Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps. PLoS Pathog 11(2): e1004643.
  3. Araújo, E. F., Loures, F. V., Bazan, S. B., Feriotti, C., Pina, A., Schanoski, A. S., Costa, T. A. and Calich, V. L. (2014). Indoleamine 2,3-dioxygenase controls fungal loads and immunity in Paracoccidioidomicosis but is more important to susceptible than resistant hosts. PLoS Negl Trop Dis 8(11): e3330. 
  4. Loures, F. V., Araújo, E. F., Feriotti, C., Bazan, S. B., Costa, T. A., Brown, G. D. and Calich, V. L. (2014). Dectin-1 induces M1 macrophages and prominent expansion of CD8+IL-17+ cells in pulmonary paracoccidioidomycosis. J Infect Dis 210(5): 762-773.
  5. Costa, T. A., Bazan, S. B., Feriotti, C., Araújo, E. F., Bassi, Ê., Loures, F. V. and Calich, V. L. (2013). In pulmonary paracoccidioidomycosis IL-10 deficiency leads to increased immunity and regressive infection without enhancing tissue pathology. PLoS Negl Trop Dis 7(10): e2512.
  6. Feriotti, C., Loures, F. V., Frank de Araújo, E., da Costa, T. A. and Calich, V. L. (2013). Mannosyl-recognizing receptors induce an M1-like phenotype in macrophages of susceptible mice but an M2-like phenotype in mice resistant to a fungal infection. PLoS One 8(1): e54845.
  7. Pina, A., de Araujo, E. F., Felonato, M., Loures, F. V., Feriotti, C., Bernardino, S., Barbuto, J. A. and Calich, V. L. (2013). Myeloid dendritic cells (DCs) of mice susceptible to paracoccidioidomycosis suppress T cell responses whereas myeloid and plasmacytoid DCs from resistant mice induce effector and regulatory T cells. Infect Immun 81(4): 1064-1077.
  8. Loures, F. V., Stroeder, H., Almeida, I. and Calich, V. L. (2012). Paracoccidioides brasiliensis lipids modulate macrophage activity via Toll-dependent or independent mechanisms. FEMS Immunol Med Microbiol 66(1): 58-70.
  9. Felonato, M., Pina, A., de Araujo, E. F., Loures, F. V., Bazan, S. B., Feriotti, C. and Calich, V. L. (2012). Anti-CD25 treatment depletes Treg cells and decreases disease severity in susceptible and resistant mice infected with Paracoccidioides brasiliensis. PLoS One 7(11): e51071.
  10. Loures, F. V., Pina, A., Felonato, M., Feriotti, C., de Araújo, E. F. and Calich, V. L. (2011). MyD88 signaling is required for efficient innate and adaptive immune responses to Paracoccidioides brasiliensis infection. Infect Immun 79(6): 2470-2480.
  11. Felonato, M., Pina, A., Bernardino, S., Loures, F. V., de Araujo, E. F. and Calich, V. L. (2010). CD28 exerts protective and detrimental effects in a pulmonary model of paracoccidioidomycosis. Infect Immun 78(11): 4922-4935.
  12. Loures, F. V., Pina, A., Felonato, M., Araújo, E. F., Leite, K. R. and Calich, V. L. (2010). Toll-like receptor 4 signaling leads to severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells. Infect Immun 78(3): 1078-1088.
  13. Loures, F. V., Pina, A., Felonato, M. and Calich, V. L. (2009). TLR2 is a negative regulator of Th17 cells and tissue pathology in a pulmonary model of fungal infection. J Immunol 183(2): 1279-1290.
  14. Calich, V. L., da Costa, T. A., Felonato, M., Arruda, C., Bernardino, S., Loures, F. V., Ribeiro, L. R., de Cassia Valente-Ferreira, R. and Pina, A. (2008). Innate immunity to Paracoccidioides brasiliensis infection. Mycopathologia 165(4-5): 223-236.
  15. Calich, V. L., Pina, A., Felonato, M., Bernardino, S., Costa, T. A. and Loures, F. V. (2008). Toll-like receptors and fungal infections: the role of TLR2, TLR4 and MyD88 in paracoccidioidomycosis. FEMS Immunol Med Microbiol 53(1): 1-7.
Protocols by Flávio V. Loures
  1. XTT Assay of Antifungal Activity