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QiChuan ZhuGe


M.D., Wenzhou Medical College, 1987

Current position

Vice President, The First Affiliated Hospital of Wenzhou Medical University, China

Publications (since 2006)

  1. Li, Q., Su, Z., Liu, J., Cai, L., Lu, J., Lin, S., Xiong, Z., Li, W., Zheng, W., Wu, J., Zhuge, Q. and Wu, Z. (2014). Dopamine receptor D2S gene transfer improves the sensitivity of GH3 rat pituitary adenoma cells to bromocriptine. Mol Cell Endocrinol 382(1): 377-384.
  2. Ruan, L., Lau, B. W., Wang, J., Huang, L., Zhuge, Q., Wang, B., Jin, K. and So, K. F. (2014). Neurogenesis in neurological and psychiatric diseases and brain injury: from bench to bedside. Prog Neurobiol 115: 116-137.
  3. Gao, L., Lu, Q., Huang, L. J., Ruan, L. H., Yang, J. J., Huang, W. L., ZhuGe, W. S., Zhang, Y. L., Fu, B., Jin, K. L. and ZhuGe, Q. C. (2014). Transplanted neural stem cells modulate regulatory T, gammadelta T cells and corresponding cytokines after intracerebral hemorrhage in rats. Int J Mol Sci 15(3): 4431-4441.
  4. Huang, L., Wu, Z. B., Zhuge, Q., Zheng, W., Shao, B., Wang, B., Sun, F. and Jin, K. (2014). Glial scar formation occurs in the human brain after ischemic stroke. Int J Med Sci 11(4): 344-348.
  5. Lu, Q., Gao, L., Huang, L., Ruan, L., Yang, J., Huang, W., Li, Z., Zhang, Y., Jin, K. and Zhuge, Q. (2014). Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat. J Neuroinflammation 11: 44.
  6. Wang, L. Q., Lin, Z. Z., Zhang, H. X., Shao, B., Xiao, L., Jiang, H. G., Zhuge, Q. C., Xie, L. K., Wang, B., Su, D. M. and Jin, K. L. (2014). Timing and dose regimens of marrow mesenchymal stem cell transplantation affect the outcomes and neuroinflammatory response after ischemic stroke. CNS Neurosci Ther 20(4): 317-326.
  7. uan, L., Zhang, Z., Mu, L., Burnley, P., Wang, L., Coder, B., Zhuge, Q. and Su, D. M. (2014). Biological significance of FoxN1 gain-of-function mutations during T and B lymphopoiesis in juvenile mice. Cell Death Dis 5: e1457.
  8. Ding, S., Yang, J., Liu, L., Ye, Y., Wang, X., Hu, J., Chen, B. and Zhuge, Q. (2014). Elevated dopamine induces minimal hepatic encephalopathy by activation of astrocytic NADPH oxidase and astrocytic protein tyrosine nitration. Int J Biochem Cell Biol 55: 252-263.
  9. Wang, L. Q., Lin, Z. Z., Zhang, H. X., Shao, B., Xiao, L., Jiang, H. G., Zhuge, Q. C., Xie, L. K., Wang, B., Su, D. M. and Jin, K. L. (2014). Timing and dose regimens of marrow mesenchymal stem cell transplantation affect the outcomes and neuroinflammatory response after ischemic stroke. CNS Neurosci Ther 20(4): 317-326.
  10. Cheng, R., Huang, W., Huang, L., Yang, B., Mao, L., Jin, K., ZhuGe, Q. and Zhao, Y. (2014). Acceleration of tissue plasminogen activator-mediated thrombolysis by magnetically powered nanomotors. ACS Nano 8(8): 7746-7754.
  11. Ding, S., Hu, J., Yang, J., Liu, L., Huang, W., Gu, X., Ye, Y., Huang, L., Liang, Y., Chen, B. and Zhuge, Q. (2014). The inactivation of JAK2/STAT3 signaling and desensitization of M1 mAChR in minimal hepatic encephalopathy (MHE) and the protection of naringin against MHE. Cell Physiol Biochem 34(6): 1933-1950.
  12. Chen, Y., Li, Z. F., Zhang, F. X., Li, J. X., Cai, L., Zhuge, Q. C. and Wu, Z. B. (2013). Gamma knife surgery for patients with volumetric classification of nonfunctioning pituitary adenomas: a systematic review and meta-analysis. Eur J Endocrinol 169(4): 487-495.
  13. Ding, S., Chen, B., Zheng, Y., Lu, Q., Liu, L. and Zhuge, Q. C. (2013). Association study of OPRM1 polymorphisms with Schizophrenia in Han Chinese population. BMC Psychiatry 13: 107. 
  14. Wang, L., Lin, Z., Shao, B., Zhuge, Q. and Jin, K. (2013). Therapeutic applications of bone marrow-derived stem cells in ischemic stroke. Neurol Res 35(5): 470-478. 
  15. Zheng, W., ZhuGe, Q., Zhong, M., Chen, G., Shao, B., Wang, H., Mao, X., Xie, L. and Jin, K. (2013). Neurogenesis in adult human brain after traumatic brain injury. J Neurotrauma 30(22): 1872-1880.
  16. ZhuGe, Q., Wu, Z., Huang, L., Zhao, B., Zhong, M., Zheng, W., GouRong, C., Mao, X., Xie, L., Wang, X. and Jin, K. (2013). Notch4 is activated in endothelial and smooth muscle cells in human brain arteriovenous malformations. J Cell Mol Med 17(11): 1458-1464.
  17. Cheng, Y., Su, Q., Shao, B., Cheng, J., Wang, H., Wang, L., Lin, Z., Ruan, L., ZhuGe, Q. and Jin, K. (2013). 17 beta -Estradiol attenuates poststroke depression and increases neurogenesis in female ovariectomized rats. Biomed Res Int 2013: 392434.
  18. Su, Z., Jiang, X., Wang, C., Liu, J., Chen, Y., Li, Q., Wu, J., Zheng, W., Zhuge, Q., Jin, K. and Wu, Z. (2012). Differential effects of nerve growth factor on expression of dopamine 2 receptor subtypes in GH3 rat pituitary tumor cells. Endocrine 42(3): 670-675.
  19. Ding, S., Liu, L., Zhuge, Q. C., Yu, Z., Zhang, X., Xie, J., Hong, W., Wang, S., Yang, Y. and Chen, B. (2012). The meta-analysis of the association of PPARG P12A, C161T polymorphism and coronary heart disease. Wien Klin Wochenschr 124(19-20): 671-677.
  20. Su, Z., Wang, C., Wu, J., Jiang, X., Chen, Y., Chen, Y., Zheng, W., Zhuge, Q., Wu, Z. and Zeng, Y. (2012). Expression of dopamine 2 receptor subtype mRNA in clinically nonfunctioning pituitary adenomas. Neurol Sci 33(2): 275-279.
  21. Sun, L., Brown, R., Chen, S., Zhuge, Q. and Su, D. M. (2012). Aging induced decline in T-lymphopoiesis is primarily dependent on status of progenitor niches in the bone marrow and thymus. Aging (Albany NY) 4(9): 606-619.
  22. Wang, C., Su, Z., Sanai, N., Xue, X., Lu, L., Chen, Y., Wu, J., Zheng, W., Zhuge, Q. and Wu, Z. B. (2012). microRNA expression profile and differentially-expressed genes in prolactinomas following bromocriptine treatment. Oncol Rep 27(5): 1312-1320.
  23. Wang, Z., Cui, C., Li, Q., Zhou, S., Fu, J., Wang, X. and Zhuge, Q. (2011). Intracerebral transplantation of foetal neural stem cells improves brain dysfunction induced by intracerebral haemorrhage stroke in mice. J Cell Mol Med 15(12): 2624-2633.
  24. Wu, Z. B., Zheng, W. M., Su, Z. P., Chen, Y., Wu, J. S., Wang, C. D., Lin, C., Zeng, Y. J. and Zhuge, Q. C. (2010). Expression of D2RmRNA isoforms and ERmRNA isoforms in prolactinomas: correlation with the response to bromocriptine and with tumor biological behavior. J Neurooncol 99(1): 25-32.
  25. ZhuGe, Q., Zhong, M., Zheng, W., Yang, G. Y., Mao, X., Xie, L., Chen, G., Chen, Y., Lawton, M. T., Young, W. L., Greenberg, D. A. and Jin, K. (2009). Notch-1 signalling is activated in brain arteriovenous malformations in humans. Brain 132(Pt 12): 3231-3241.
  26. Wu, Z. B., Su, Z. P., Wu, J. S., Zheng, W. M., Zhuge, Q. C. and Zhong, M. (2008). Five years follow-up of invasive prolactinomas with special reference to the control of cavernous sinus invasion. Pituitary 11(1): 63-70.
  27. Ye, S., Su, Z. P., Zhang, J., Qian, X., Zhuge, Q. C. and Zeng, Y. J. (2008). Differential centrifugation in culture and differentiation of rat neural stem cells. Cell Mol Neurobiol 28(4): 511-517.
  28. Wu, Z. B., Yu, C. J., Su, Z. P., Zhuge, Q. C., Wu, J. S. and Zheng, W. M. (2006). Bromocriptine treatment of invasive giant prolactinomas involving the cavernous sinus: results of a long-term follow up. J Neurosurg 104(1): 54-61.
Protocols by QiChuan ZhuGe
  1. A Rat Model of Intracerebral Hemorrhage Induced by Collagenase IV