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Ramalingam Bethunaickan

Education

Ph.D. In Bio Medical Sciences, from Tuberculosis Research Centre (ICMR), Chennai, India, 2003

Current position

Post Doctoral Fellow at Feinstein Institute for Medical Research, Manhasset, New York-11031

Publications (since 2005)

  1. Moisini, I., Huang, W., Bethunaickan, R., Sahu, R., Ricketts, P. G., Akerman, M., Marion, T., Lesser, M. and Davidson, A. (2012). The Yaa locus and IFN-alpha fine-tune germinal center B cell selection in murine systemic lupus erythematosus. J Immunol 189(9): 4305-4312.
  2. Berthier, C. C.*, Bethunaickan, R.*, Gonzalez-Rivera, T.*, Nair, V., Ramanujam, M., Zhang, W., Bottinger, E. P., Segerer, S., Lindenmeyer, M., Cohen, C. D., Davidson, A. and Kretzler, M. (2012). Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis. J Immunol 189(2): 988-1001.
  3. Bethunaickan, R., Sahu, R., Liu, Z., Tang, Y. T., Huang, W., Edegbe, O., Tao, H., Ramanujam, M., Madaio, M. P. and Davidson, A. (2012). Anti-tumor necrosis factor alpha treatment of interferon-alpha-induced murine lupus nephritis reduces the renal macrophage response but does not alter glomerular immune complex formation. Arthritis Rheum 64(10): 3399-3408.
  4. Bethunaickan, R., Sahu, R. and Davidson, A. (2012). Analysis of renal mononuclear phagocytes in murine models of SLE. Methods Mol Biol 900: 207-232.
  5. Huang, W., Moisini, I., Bethunaickan, R., Sahu, R., Akerman, M., Eilat, D., Lesser, M. and Davidson, A. (2011). BAFF/APRIL inhibition decreases selection of naive but not antigen-induced autoreactive B cells in murine systemic lupus erythematosus. J Immunol 187(12): 6571-6580.
  6. Liu, Z., Bethunaickan, R., Huang, W., Ramanujam, M., Madaio, M. P. and Davidson, A. (2011). IFN-alpha confers resistance of systemic lupus erythematosus nephritis to therapy in NZB/W F1 mice. J Immunol 187(3): 1506-1513.
  7. Bethunaickan, R., Berthier, C. C., Ramanujam, M., Sahu, R., Zhang, W., Sun, Y., Bottinger, E. P., Ivashkiv, L., Kretzler, M. and Davidson, A. (2011). A unique hybrid renal mononuclear phagocyte activation phenotype in murine systemic lupus erythematosus nephritis. J Immunol 186(8): 4994-5003.
  8. Liu, Z., Bethunaickan, R., Huang, W., Lodhi, U., Solano, I., Madaio, M. P. and Davidson, A. (2011). Interferon-alpha accelerates murine systemic lupus erythematosus in a T cell-dependent manner. Arthritis Rheum 63(1): 219-229.
  9. Ramanujam, M., Bethunaickan, R., Huang, W., Tao, H., Madaio, M. P. and Davidson, A. (2010). Selective blockade of BAFF for the prevention and treatment of systemic lupus erythematosus nephritis in NZM2410 mice. Arthritis Rheum 62(5): 1457-1468.
  10. Kahn, P., Ramanujam, M., Bethunaickan, R., Huang, W., Tao, H., Madaio, M. P., Factor, S. M. and Davidson, A. (2008). Prevention of murine antiphospholipid syndrome by BAFF blockade. Arthritis Rheum 58(9): 2824-2834.
  11. Raja, A., Ranganathan, U. D. and Bethunaickan, R. (2008). Improved diagnosis of pulmonary tuberculosis by detection of antibodies against multiple Mycobacterium tuberculosis antigens. Diagn Microbiol Infect Dis 60(4): 361-368.
  12. Schiffer, L., Bethunaickan, R., Ramanujam, M., Huang, W., Schiffer, M., Tao, H., Madaio, M. P., Bottinger, E. P. and Davidson, A. (2008). Activated renal macrophages are markers of disease onset and disease remission in lupus nephritis. J Immunol 180(3): 1938-1947.
  13. Bethunaickan, R., Baulard, A. R., Locht, C. and Raja, A. (2007). Antibody response in pulmonary tuberculosis against recombinant 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis. Scand J Infect Dis 39(10): 867-874.
  14. Srivastava, V., Rouanet, C., Srivastava, R., Ramalingam, B., Locht, C. and Srivastava, B. S. (2007). Macrophage-specific Mycobacterium tuberculosis genes: identification by green fluorescent protein and kanamycin resistance selection. Microbiology 153(Pt 3): 659-666.
  15. Raja, A., Ranganathan, U. D. and Ramalingam, B. (2006). Clinical value of specific detection of immune complex-bound antibodies in pulmonary tuberculosis. Diagn Microbiol Infect Dis 56(3): 281-287.
Protocols by Ramalingam Bethunaickan
  1. Process and Analysis of Kidney Infiltrates by Flow Cytometry from Murine Lupus Nephritis
  2. Isolation of Dendritic Cells and Macrophages from the Murine Kidneys of Lupus by Cell Sorter
  3. Isolation of Circulating Immune Complexes from TB Patient Serum for Serodiagnosis