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Alan John Alexander McBride

Education

Ph.D. in Biochemistry and Applied Molecular Biology, University of Manchester Institute of Science and Technology (UMIST), 1995

Current position

Lecturer in Biotechnology, Technology Development Centre, Federal University of Pelotas (UFPel), Pelotas, RS, Brazil

Publications (since 2005)

  1. Bacelo, K. L., Hartwig, D. D., Seixas, F. K., Schuch, R., Moreira Ada, S., Amaral, M., Collares, T., Vendrusculo, C. T., McBride, A. J. and Dellagostin, O. A. (2014). Xanthan gum as an adjuvant in a subunit vaccine preparation against leptospirosis. Biomed Res Int 2014: 636491.
  2. Hartwig, D. D., Bacelo, K. L., Oliveira, P. D., Oliveira, T. L., Seixas, F. K., Amaral, M. G., Hartleben, C. P., McBride, A. J. and Dellagostin, O. A. (2014). Mannosylated LigANI produced in Pichia pastoris protects hamsters against leptospirosis. Curr Microbiol 68(4): 524-530.
  3. Moreira, G. M., TelmoPde, L., Mendonca, M., Moreira, A. N., McBride, A. J., Scaini, C. J. and Conceicao, F. R. (2014). Human toxocariasis: current advances in diagnostics, treatment, and interventions. Trends Parasitol 30(9): 456-464.
  4. Forster, K. M., Hartwig, D. D., Seixas, F. K., McBride, A. J., Monte, L. G., Recuero, A. L., Brod, C. S., Hartleben, C. P., Amaral, M. and Dellagostin, O. A. (2013). Characterization of a virulent Leptospira interrogans strain isolated from an abandoned swimming pool. Braz J Microbiol 44(1): 165-170.
  5. Hartwig, D. D., Forster, K. M., Oliveira, T. L., Amaral, M., McBride, A. J. and Dellagostin, O. A. (2013). A prime-boost strategy using the novel vaccine candidate, LemA, protects hamsters against leptospirosis. Clin Vaccine Immunol 20(5): 747-752.
  6. Oliveira, P. D., Michel, R. C., McBride, A. J., Moreira, A. S., Lomba, R. F. and Vendruscolo, C. T. (2013). Concentration regimes of biopolymers xanthan, tara, and clairana, comparing dynamic light scattering and distribution of relaxation time. PLoS One 8(5): e62713.
  7. Schoenardie, E. R., Scaini, C. J., Brod, C. S., Pepe, M. S., Villela, M. M., McBride, A. J., Borsuk, S. and Berne, M. E. (2013). Seroprevalence of Toxocara infection in children from southern Brazil. J Parasitol 99(3): 537-539.
  8. Collares, T. F., Campos, V. F., Urtiaga, G., Leon, P. M., Amaral, M. G., Hartleben, C. P., McBride, A. J., Dellagostin, O. A., Deschamps, J. C., Seixas, F. K. and Collares, T. (2013). Erythropoietin non-viral gene therapy does not affect motility, viability, morphology or concentration of rabbit sperm. Animal 7(5): 778-783.
  9. Moreira, G. M., Conceicao, F. R., McBride, A. J. and Pinto Lda, S. (2013). Structure predictions of two Bauhinia variegata lectins reveal patterns of C-terminal properties in single chain legume lectins. PLoS One 8(11): e81338.
  10. Leon, P. M., Campos, V. F., Kaefer, C., Begnini, K. R., McBride, A. J., Dellagostin, O. A., Seixas, F. K., Deschamps, J. C. and Collares, T. (2013). Expression of apoptotic genes in immature and in vitro matured equine oocytes and cumulus cells. Zygote 21(3): 279-285.
  11. Chagas-Junior, A. D., da Silva, C. L., Soares, L. M., Santos, C. S., Silva, C. D., Athanazio, D. A., dos Reis, M. G., McBride, F. W. and McBride, A. J. (2012). Detection and quantification of Leptospira interrogans in hamster and rat kidney samples: immunofluorescent imprints versus real-time PCR. PLoS One 7(2): e32712.
  12. Campos, V. F., Robaldo, R. B., Deschamps, J. C., Seixas, F. K., McBride, A. J., Marins, L. F., Okamoto, M., Sampaio, L. A. and Collares, T. (2012). Neuropeptide Y gene expression around meal time in the Brazilian flounder Paralichthys orbignyanus. J Biosci 37(2): 227-232.
  13. Nedel, F., Campos, V. F., Alves, D., McBride, A. J., Dellagostin, O. A., Collares, T., Savegnago, L. and Seixas, F. K. (2012). Substituted diaryl diselenides: cytotoxic and apoptotic effect in human colon adenocarcinoma cells. Life Sci 91(9-10): 345-352.
  14. Hartwig, D. D., Seixas, F. K., Cerqueira, G. M., McBride, A. J. and Dellagostin, O. A. (2011). Characterization of the immunogenic and antigenic potential of putative lipoproteins from Leptospira interrogans. Curr Microbiol 62(4): 1337-1341.
  15. Bandeira, M., Santos, C. S., de Azevedo, E. C., Soares, L. M., Macedo, J. O., Marchi, S., da Silva, C. L., Chagas-Junior, A. D., McBride, A. J., McBride, F. W., Reis, M. G. and Athanazio, D. A. (2011). Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. Infect Immun 79(7): 2936-2940.
  16. Dellagostin, O. A., Grassmann, A. A., Hartwig, D. D., Felix, S. R., da Silva, E. F. and McBride, A. J. (2011). Recombinant vaccines against leptospirosis. Hum Vaccin 7(11): 1215-1224.
  17. Cerqueira, G. M., McBride, A. J., Queiroz, A., Pinto, L. S., Silva, E. F., Hartskeerl, R. A., Reis, M. G., Ko, A. I. and Dellagostin, O. A. (2010). Monitoring Leptospira strain collections: the need for quality control. Am J Trop Med Hyg 82(1): 83-87.
  18. Santos, C. S., Macedo, J. O., Bandeira, M., Chagas-Junior, A. D., McBride, A. J., McBride, F. W., Reis, M. G. and Athanazio, D. A. (2010). Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes. J Med Microbiol 59(Pt 9): 1101-1106.
  19. Cerqueira, G. M., McBride, A. J., Hartskeerl, R. A., Ahmed, N., Dellagostin, O. A., Eslabao, M. R. and Nascimento, A. L. (2010). Bioinformatics describes novel Loci for high resolution discrimination of leptospira isolates. PLoS One 5(10): e15335.
  20. Hartwig, D. D., Oliveira, T. L., Seixas, F. K., Forster, K. M., Rizzi, C., Hartleben, C. P., McBride, A. J. and Dellagostin, O. A. (2010). High yield expression of leptospirosis vaccine candidates LigA and LipL32 in the methylotrophic yeast Pichia pastoris. Microb Cell Fact 9: 98.
  21. Chagas-Junior, A. D., McBride, A. J., Athanazio, D. A., Figueira, C. P., Medeiros, M. A., Reis, M. G., Ko, A. I. and McBride, F. W. (2009). An imprint method for detecting leptospires in the hamster model of vaccine-mediated immunity for leptospirosis. J Med Microbiol 58(Pt 12): 1632-1637.
  22. McBride, A. J., Cerqueira, G. M., Suchard, M. A., Moreira, A. N., Zuerner, R. L., Reis, M. G., Haake, D. A., Ko, A. I. and Dellagostin, O. A. (2009). Genetic diversity of the Leptospiral immunoglobulin-like (Lig) genes in pathogenic Leptospira spp. Infect Genet Evol 9(2): 196-205.
  23. Cerqueira, G. M., McBride, A. J., Picardeau, M., Ribeiro, S. G., Moreira, A. N., Morel, V., Reis, M. G., Ko, A. I. and Dellagostin, O. A. (2009). Distribution of the leptospiral immunoglobulin-like (lig) genes in pathogenic Leptospira species and application of ligB to typing leptospiral isolates. J Med Microbiol 58(Pt 9): 1173-1181.
  24. Athanazio, D. A., Silva, E. F., Santos, C. S., Rocha, G. M., Vannier-Santos, M. A., McBride, A. J., Ko, A. I. and Reis, M. G. (2008). Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans. Acta Trop 105(2): 176-180.
  25. Reis, E. A., Athanazio, D. A., McBride, A. J., Azevedo, T. M., Magalhaes-Santos, I. F., Harn, D. and Reis, M. G. (2008). Influence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection. Acta Trop 108(2-3): 131-134.
  26. deFaria, M. T., Calderwood, M. S., Athanazio, D. A., McBride, A. J., Hartskeerl, R. A., Pereira, M. M., Ko, A. I. and Reis, M. G. (2008). Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil. Acta Trop 108(1): 1-5.
  27. Fernandes, C. P., Seixas, F. K., Coutinho, M. L., Vasconcellos, F. A., Seyffert, N., Croda, J., McBride, A. J., Ko, A. I., Dellagostin, O. A. and Aleixo, J. A. (2007). Monoclonal antibodies against LipL32, the major outer membrane protein of pathogenic Leptospira: production, characterization, and testing in diagnostic applications. Hybridoma (Larchmt) 26(1): 35-41.
  28. McBride, A. J., Pereira, F. A., da Silva, E. D., de Matos, R. B., da Silva, E. D., Ferreira, A. G., Reis, M. G. and Ko, A. I. (2007). Evaluation of the EIE-IgM-Leptospirose assay for the serodiagnosis of leptospirosis. Acta Trop 102(3): 206-211.
  29. McBride, A. J., Santos, B. L., Queiroz, A., Santos, A. C., Hartskeerl, R. A., Reis, M. G. and Ko, A. I. (2007). Evaluation of four whole-cell Leptospira-based serological tests for diagnosis of urban leptospirosis. Clin Vaccine Immunol 14(9): 1245-1248. 
  30. Silva, E. F., Medeiros, M. A., McBride, A. J., Matsunaga, J., Esteves, G. S., Ramos, J. G., Santos, C. S., Croda, J., Homma, A., Dellagostin, O. A., Haake, D. A., Reis, M. G. and Ko, A. I. (2007). The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis. Vaccine 25(33): 6277-6286.
  31. Reis, E. A., Azevedo, T. M., McBride, A. J., Harn, D. A., Jr. and Reis, M. G. (2007). Naive donor responses to Schistosoma mansoni soluble egg antigens. Scand J Immunol 66(6): 662-670. 
  32. Maciel, E. A., Athanazio, D. A., Reis, E. A., Cunha, F. Q., Queiroz, A., Almeida, D., McBride, A. J., Ko, A. I. and Reis, M. G. (2006). High serum nitric oxide levels in patients with severe leptospirosis. Acta Trop 100(3): 256-260.
  33. McBride, A. J., Athanazio, D. A., Reis, M. G. and Ko, A. I. (2005). Leptospirosis. CurrOpin Infect Dis 18(5): 376-386.


Protocols by Alan John Alexander McBride
  1. Generation of Mammalian Host-adapted Leptospira interrogans by Cultivation in Peritoneal Dialysis Membrane Chamber Implantation in Rats