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André Alex Grassmann

André Alex Grassmann


Ph.D. in Biotechnology, Federal University of Pelotas - UFPel, Brazil, 2015

Current position

Postdoctoral Researcher, Federal University of Pelotas - UFPel, Brazil


  1. Caimano, M. J., Sivasankaran, S. K., Allard, A., Hurley, D., Hokamp, K., Grassmann, A. A., Hinton, J. C. and Nally, J. E. (2014). A model system for studying the transcriptomic and physiological changes associated with mammalian host-adaptation by Leptospira interrogans serovar Copenhageni. PLoS Pathog 10(3): e1004004.
  2. Grassmann, A. A., Felix, S. R., dos Santos, C. X., Amaral, M. G., SeixasNeto, A. C., Fagundes, M. Q., Seixas, F. K., da Silva, E. F., Conceicao, F. R. and Dellagostin, O. A. (2012). Protection against lethal leptospirosis after vaccination with LipL32 coupled or coadministered with the B subunit of Escherichia coli heat-labile enterotoxin. Clin Vaccine Immunol 19(5): 740-745.
  3. Diniz, J. A., Felix, S. R., Bonel-Raposo, J., SeixasNeto, A. C., Vasconcellos, F. A., Grassmann, A. A., Dellagostin, O. A., Aleixo, J. A. and da Silva, E. F. (2011). Highly virulent Leptospira borgpetersenii strain characterized in the hamster model. Am J Trop Med Hyg 85(2): 271-274.
  4. Dellagostin, O. A., Grassmann, A. A., Hartwig, D. D., Felix, S. R., da Silva, E. F. and McBride, A. J. (2011). Recombinant vaccines against leptospirosis. Hum Vaccin 7(11): 1215-1224.
  5. da Silva, E. F., Felix, S. R., Cerqueira, G. M., Fagundes, M. Q., Neto, A. C., Grassmann, A. A., Amaral, M. G., Gallina, T. and Dellagostin, O. A. (2010). Preliminary characterization of Mus musculus-derived pathogenic strains of Leptospira borgpetersenii serogroup Ballum in a hamster model. Am J Trop Med Hyg 83(2): 336-337.
  6. Felix, S.R., Silva, É.F.,Jouglard, S.D.D., Hartmann, D.M.,Grassmann, A.A. andDellagostin, O.A.(2009).Leptospirosis vaccine: search for subunit candidates. Procedia Vaccinology 1: 110-114.
  7. da Silva Ramos Rocha, A., Conceicao, F. R., Grassmann, A. A., Lagranha, V. L. and Dellagostin, O. A. (2008). B subunit of Escherichia coli heat-labile enterotoxin as adjuvant of humoral immune response in recombinant BCG vaccination. Can J Microbiol 54(8): 677-686.
Protocols by André Alex Grassmann
  1. Generation of Mammalian Host-adapted Leptospira interrogans by Cultivation in Peritoneal Dialysis Membrane Chamber Implantation in Rats