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Omar Akil


Ph.D. in Biochemistry and Enzymology, University of Science Casablanca Morocco

Current position

Assistant Professor, University of California San Francisco. His research focuses on the molecular biology of hearing, with an emphasis on auditory hair cell physiology and cochlear gene therapy.


  1. Lustig, L. R., Alemi, S., Sun, Y., Grabowski, G. and Akil, O. (2016). Role of saposin C and D in auditory and vestibular function. Laryngoscope 126(2): 452-459.
  2. Akil, O., Rouse, S. and Lustig, L. (2015). The role of saposins in auditory and vestibular systems. Medical Research Archives KEI Journals.
  3. Akil, O., Rouse, S. L., Chan, D. K. and Lustig, L. R. (2015). Surgical method for virally mediated gene delivery to the mouse inner ear through the round window membrane. J Vis Exp (97).
  4. Akil, O., Sun, Y., Vijayakumar, S., Zhang, W., Ku, T., Lee, C. K., Jones, S., Grabowski, G. A. and Lustig, L. R. (2015). Spiral ganglion degeneration and hearing loss as a consequence of satellite cell death in saposin B-deficient mice. J Neurosci 35(7): 3263-3275.
  5. Akil, O., Hall-Glenn, F., Chang, J., Li, A., Chang, W., Lustig, L. R., Alliston, T. and Hsiao, E. C. (2014). Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia. PLoS One 9(5): e94989.
  6. Akil, O. and Lustig, L. R. (2013). Mouse cochlear whole mount immunofluorescence. Bio-protocol 3(5): e332. 
  7. Park, S. N., Back, S. A., Park, K. H., Seo, J. H., Noh, H. I., Akil, O., Lustig, L. R. and Yeo, S. W. (2013). Comparison of functional and morphologic characteristics of mice models of noise-induced hearing loss. Auris Nasus Larynx 40(1): 11-17.
  8. Akil, O., Seal, R. P., Burke, K., Wang, C., Alemi, A., During, M., Edwards, R. H. and Lustig, L. R. (2012). Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy. Neuron 75(2): 283-293.
  9. Akil, O. and Lustig, L. R. (2012). Severe vestibular dysfunction and altered vestibular innervation in mice lacking prosaposin. Neurosci Res 72(4): 296-305.
  10. Lustig, L. R. and Akil, O. (2012). Cochlear gene therapy. Curr Opin Neurol 25(1): 57-60.
  11. Park, S. N., Back, S. A., Choung, Y. H., Kim, H. L., Akil, O., Lustig, L. R., Park, K. H. and Yeo, S. W. (2011). alpha-Synuclein deficiency and efferent nerve degeneration in the mouse cochlea: a possible cause of early-onset presbycusis. Neurosci Res 71(3): 303-310.
  12. Chang, J. L., Brauer, D. S., Johnson, J., Chen, C. G., Akil, O., Balooch, G., Humphrey, M. B., Chin, E. N., Porter, A. E., Butcher, K., Ritchie, R. O., Schneider, R. A., Lalwani, A., Derynck, R., Marshall, G. W., Marshall, S. J., Lustig, L. and Alliston, T. (2010). Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-beta and Runx2 in bone is required for hearing. EMBO Rep 11(10): 765-771.
  13. More, S. S., Akil, O., Ianculescu, A. G., Geier, E. G., Lustig, L. R. and Giacomini, K. M. (2010). Role of the copper transporter, CTR1, in platinum-induced ototoxicity. J Neurosci 30(28): 9500-9509.
  14. Akil. O., Kebbaj. Z. E. I., Latruffe, N. and Kebbaj, M. (2009). D-3-hydroxybutyrate oxidation in mitochondria by D-3-Hydroxybutyrate dehydrogenase in Tetrahymena pyriformis. African Journal of Biochemistry Research 3 (3): 029-036.
  15. Akil, O., Weber, C. M., Park, S. N., Ninkina, N., Buchman, V. and Lustig, L. R. (2008). Localization of synucleins in the mammalian cochlea. J Assoc Res Otolaryngol 9(4): 452-463.
  16. Osman, A. A., Schrader, A. D., Hawkes, A. J., Akil, O., Bergeron, A., Lustig, L. R. and Simmons, D. D. (2008). Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear. Mol Cell Neurosci 38(2): 153-169.
  17. Seal, R. P., Akil, O., Yi, E., Weber, C. M., Grant, L., Yoo, J., Clause, A., Kandler, K., Noebels, J. L., Glowatzki, E., Lustig, L. R. and Edwards, R. H. (2008). Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron 57(2): 263-275.
  18. Akil, O., Chang, J., Hiel, H., Kong, J. H., Yi, E., Glowatzki, E. and Lustig, L. R. (2006). Progressive deafness and altered cochlear innervation in knock-out mice lacking prosaposin. J Neurosci 26(50): 13076-13088.
Protocols by Omar Akil
  1. Mouse Cochlear Whole Mount Immunofluorescence
  2. Mouse Auditory Brainstem Response Testing