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Xiaoyang Wang

Education

Ph.D. in Institute of Neuroscience and Physiology, University of Gothenburg, Sweden, 2004

Current position

Associate Professor, Institute of Neuroscience and Physiology, University of Gothenburg, Sweden (2013–present)

Publications (since 2010)

  1. Bi, D., Qiao, L., Bergelson, I., Ek, C. J., Duan, L., Zhang, X., Albertsson, A. M., Pettengill, M., Kronforst, K., Ninkovic, J., Goldmann, D., Janzon, A., Hagberg, H., Wang, X.*, Mallard, C.* and Levy, O.* (2015). Staphylococcus epidermidis bacteremia induces brain injury in neonatal mice via toll-like receptor 2-dependent and -independent pathways. J Infect Dis. (*Equal contribution senior authors; Wang X is the corresponding author)
  2. Ali, A., Zhu, X., Kwiecinski, J., Gjertsson, I., Lindholm, C., Iwakura, Y., Wang, X., Lycke, N., Josefsson, E., Pullerits, R. and Jin, T. (2015). Antibiotic-killed Staphylococcus aureus induces destructive arthritis in mice. Arthritis Rheumatol 67(1): 107-116.
  3. Albertsson, A. M., Bi, D., Duan, L., Zhang, X., Leavenworth, J. W., Qiao, L., Zhu, C., Cardell, S., Cantor, H., Hagberg, H., Mallard, C. and Wang, X. (2014). The immune response after hypoxia-ischemia in a mouse model of preterm brain injury. J Neuroinflammation 11: 153.
  4. Albertsson, A. M., Zhang, X., Leavenworth, J., Bi, D., Nair, S., Qiao, L., Hagberg, H., Mallard, C., Cantor, H. and Wang, X. (2014). The effect of osteopontin and osteopontin-derived peptides on preterm brain injury. J Neuroinflammation 11: 197.
  5. Bi, D., Chen, M., Zhang, X., Wang, H., Xia, L., Shang, Q., Li, T., Zhu, D., Blomgren, K., He, L., Wang, X., Xing, Q. and Zhu, C. (2014). The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy. J Neuroinflammation 11: 100.
  6. Xie, C., Zhou, K., Wang, X., Blomgren, K. and Zhu, C. (2014). Therapeutic benefits of delayed lithium administration in the neonatal rat after cerebral hypoxia-ischemia. PLoS One 9(9): e107192.
  7. Han, W., Sun, Y., Wang, X., Zhu, C. and Blomgren, K. (2014). Delayed, long-term administration of the caspase inhibitor Q-VD-OPh reduced brain injury induced by neonatal hypoxia-ischemia. Dev Neurosci 36(1): 64-72.
  8. Sun, H., Cheng, R., Kang, W., Xiong, H., Zhou, C., Zhang, Y., Wang, X. and Zhu, C. (2014). High-frequency oscillatory ventilation versus synchronized intermittent mandatory ventilation plus pressure support in preterm infants with severe respiratory distress syndrome. Respir Care 59(2): 159-169.
  9. Leavenworth, J. W., Tang, X., Kim, H. J., Wang, X. and Cantor, H. (2013). Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells. J Clin Invest 123(3): 1382-1389.
  10. Stridh, L., Mottahedin, A., Johansson, M. E., Valdez, R. C., Northington, F., Wang, X. and Mallard, C. (2013). Toll-like receptor-3 activation increases the vulnerability of the neonatal brain to hypoxia-ischemia. J Neurosci 33(29): 12041-12051.
  11. Correa, F., Ljunggren, E., Patil, J., Wang, X., Hagberg, H., Mallard, C. and Sandberg, M. (2013). Time-dependent effects of systemic lipopolysaccharide injection on regulators of antioxidant defence Nrf2 and PGC-1alpha in the neonatal rat brain. Neuroimmunomodulation 20(4): 185-193.
  12. Stridh, L., Ek, C. J., Wang, X., Nilsson, H. and Mallard, C. (2013). Regulation of Toll-like receptors in the choroid plexus in the immature brain after systemic inflammatory stimuli. Transl Stroke Res 4(2): 220-227.
  13. Zhu, C., Sun, Y., Gao, J., Wang, X., Plesnila, N. and Blomgren, K. (2013). Inhaled nitric oxide protects males but not females from neonatal mouse hypoxia-ischemia brain injury. Transl Stroke Res 4(2): 201-207.
  14. Kronforst, K. D., Mancuso, C. J., Pettengill, M., Ninkovic, J., Power Coombs, M. R., Stevens, C., Otto, M., Mallard, C., Wang, X., Goldmann, D. and Levy, O. (2012). A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses. PLoS One 7(9): e43897.
  15. You, F., Huo, K., Wang, R., Xu, D., Deng, J., Wei, Y., Shi, F., Liu, H., Cheng, G., Zhang, Z., Yang, P., Sun, T., Wang, X., Jacobsson, B. and Zhu, C. (2012). Maternal mortality in Henan Province, China: changes between 1996 and 2009. PLoS One 7(10): e47153.
  16. Huo, K., Sun, Y., Li, H., Du, X., Wang, X., Karlsson, N., Zhu, C. and Blomgren, K. (2012). Lithium reduced neural progenitor apoptosis in the hippocampus and ameliorated functional deficits after irradiation to the immature mouse brain. Mol Cell Neurosci 51(1-2): 32-42.
  17. Carlsson, Y., Schwendimann, L., Vontell, R., Rousset, C. I., Wang, X., Lebon, S., Charriaut-Marlangue, C., Supramaniam, V., Hagberg, H., Gressens, P. and Jacotot, E. (2011). Genetic inhibition of caspase-2 reduces hypoxic-ischemic and excitotoxic neonatal brain injury. Ann Neurol 70(5): 781-789.
  18. Sun, Y., Zhang, Y., Wang, X., Blomgren, K. and Zhu, C. (2012). Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatal hippocampus after cerebral hypoxia-ischemia. Mol Neurodegener 7: 17.
  19. Leavenworth, J. W.*, Wang, X.*, Wenander, C. S., Spee, P. and Cantor, H. (2011). Mobilization of natural killer cells inhibits development of collagen-induced arthritis. Proc Natl Acad Sci U S A 108(35): 14584-14589. (*Wang X is an equally contributing first author)
  20. Du, X., Fleiss, B., Li, H., D'Angelo, B., Sun, Y., Zhu, C., Hagberg, H., Levy, O., Mallard, C. and Wang, X. (2011). Systemic stimulation of TLR2 impairs neonatal mouse brain development. PLoS One 6(5): e19583.
  21. Wang, X., Leverin, A. L., Han, W., Zhu, C., Johansson, B. R., Jacotot, E., Ten, V. S., Sims, N. R. and Hagberg, H. (2011). Isolation of brain mitochondria from neonatal mice. J Neurochem 119(6): 1253-1261.
  22. Stridh, L., Smith, P. L., Naylor, A. S., Wang, X. and Mallard, C. (2011). Regulation of toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia. J Neuroinflammation 8: 45.
  23. Gressens, P., Le Verche, V., Fraser, M., Rousset, C. I., Schwendimann, L., Bennet, L., George, S. A., Wang, X., Mallard, C., Tilley, B. C., Dournaud, P., Gunn, A. J., Hagberg, H. and Levison, S. W. (2011). Pitfalls in the quest of neuroprotectants for the perinatal brain. Dev Neurosci 33(3-4): 189-198.
  24. Chauvier, D., Renolleau, S., Holifanjaniaina, S., Ankri, S., Bezault, M., Schwendimann, L., Rousset, C., Casimir, R., Hoebeke, J., Smirnova, M., Debret, G., Trichet, A. P., Carlsson, Y., Wang, X., Bernard, E., Hebert, M., Rauzier, J. M., Matecki, S., Lacampagne, A., Rustin, P., Mariani, J., Hagberg, H., Gressens, P., Charriaut-Marlangue, C. and Jacotot, E. (2011). Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor. Cell Death Dis 2: e203.
  25. Li, H., Li, Q., Du, X., Sun, Y., Wang, X., Kroemer, G., Blomgren, K. and Zhu, C. (2011). Lithium-mediated long-term neuroprotection in neonatal rat hypoxia-ischemia is associated with antiinflammatory effects and enhanced proliferation and survival of neural stem/progenitor cells. J Cereb Blood Flow Metab 31(10): 2106-2115.
  26. Carlsson, Y., Schwendimann, L., Vontell, R., Rousset, C. I., Wang, X., Lebon, S., Charriaut-Marlangue, C., Supramaniam, V., Hagberg, H., Gressens, P. and Jacotot, E. (2011). Genetic inhibition of caspase-2 reduces hypoxic-ischemic and excitotoxic neonatal brain injury. Ann Neurol 70(5): 781-789.
  27. Hellgren, G., Han, W., Wang, X., Lofqvist, C., Hagberg, H., Mallard, C. and Hellstrom, A. (2011). Safety aspects of longitudinal administration of IGF-I/IGFBP-3 complex in neonatal mice. Growth Horm IGF Res 21(4): 205-211.
  28. Gao, J., Wang, S., Wang, X. and Zhu, C. (2011). Electroacupuncture enhances cell proliferation and neuronal differentiation in young rat brains. Neurol Sci 32(3): 369-374.
  29. Han, W., Song, J., Liu, A., Huo, K., Xu, F., Cui, S., Wang, X. and Zhu, C. (2011). Trends in live births in the past 20 years in Zhengzhou, China. Acta Obstet Gynecol Scand 90(4): 332-337.
  30. Huo, K., Zhang, Z., Zhao, D., Li, H., Wang, J., Wang, X., Feng, H., Wang, X. and Zhu, C. (2011). Risk factors for neurodevelopmental deficits in congenital hypothyroidism after early substitution treatment. Endocr J 58(5): 355-361.
  31. Li, Q., Li, H., Roughton, K., Wang, X., Kroemer, G., Blomgren, K. and Zhu, C. (2010). Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia. Cell Death Dis 1: e56.
  32. Wang, X., Han, W., Du, X., Zhu, C., Carlsson, Y., Mallard, C., Jacotot, E. and Hagberg, H. (2010). Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injury. Stroke 41(9): 2050-2055.
  33. Huo, K., Zhao, Y., Feng, H., Yao, M., Savman, K., Wang, X. and Zhu, C. (2010). Mortality rates of children aged under five in Henan province, China, 2004-2008. Paediatr Perinat Epidemiol 24(4): 343-348.
  34. Dean, J. M., Wang, X., Kaindl, A. M., Gressens, P., Fleiss, B., Hagberg, H. and Mallard, C. (2010). Microglial MyD88 signaling regulates acute neuronal toxicity of LPS-stimulated microglia in vitro. Brain Behav Immun 24(5): 776-783.
Protocols by Xiaoyang Wang
  1. A Mouse Model of Preterm Brain Injury after Hypoxia-Ischemia