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Jeremy Thorner


Ph.D. in Biochemistry, Department of Biological Chemistry, Division of Medical Sciences, Harvard University, Cambridge, MA, USA, 1972

Current position

Professor in Biochemistry, Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA

Publications (since 2010)

  1. Finnigan, G. C., Booth, E. A., Duvalyan, A., Liao, E. N. and Thorner, J. (2015). The Carboxy-Terminal Tails of Septins Cdc11 and Shs1 Recruit Myosin-II Binding Factor Bni5 to the Bud Neck in Saccharomyces cerevisiae. Genetics. (Epub ahead of print)
  2. Finnigan, G. C., Takagi, J., Cho, C. and Thorner, J. (2015). Comprehensive Genetic Analysis of Paralogous Terminal Septin Subunits Shs1 and Cdc11 in Saccharomyces cerevisiae. Genetics. (Epub ahead of print)
  3. Johnson, C. R., Weems, A. D., Brewer, J. M., Thorner, J. and McMurray, M. A. (2015). Cytosolic chaperones mediate quality control of higher-order septin assembly in budding yeast. Mol Biol Cell 26(7): 1323-1344.
  4. Roelants, F. M., Su, B. M., von Wulffen, J., Ramachandran, S., Sartorel, E., Trott, A. E. and Thorner, J. (2015). Protein kinase Gin4 negatively regulates flippase function and controls plasma membrane asymmetry. J Cell Biol 208(3): 299-311.
  5. O'Donnell, A. F., McCartney, R. R., Chandrashekarappa, D. G., Zhang, B. B., Thorner, J. and Schmidt, M. C. (2015). 2-Deoxyglucose impairs Saccharomyces cerevisiae growth by stimulating Snf1-regulated and alpha-arrestin-mediated trafficking of hexose transporters 1 and 3. Mol Cell Biol 35(6): 939-955.
  6. Sartorel, E., Barrey, E., Lau, R. K. and Thorner, J. (2015). Plasma membrane aminoglycerolipid flippase function is required for signaling competence in the yeast mating pheromone response pathway. Mol Biol Cell 26(1): 134-150.
  7. Thorner, J., Hunter, T., Cantley, L. C. and Sever, R. (2014). Signal transduction: From the atomic age to the post-genomic era. Cold Spring Harb Perspect Biol 6(12): a022913.
  8. Muir, A., Ramachandran, S., Roelants, F. M., Timmons, G. and Thorner, J. (2014). TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids. Elife 3.
  9. Cantley, L. C., Hunter, T., Sever, R. and Thorner, J. (eds). (2014). Signal Transduction: Principles, Pathways, and Processes. Cold Spring Harbor Laboratory Press, 452.
  10. Alvaro, C. G., O'Donnell, A. F., Prosser, D. C., Augustine, A. A., Goldman, A., Brodsky, J. L., Cyert, M. S., Wendland, B. and Thorner, J. (2014). Specific alpha-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2. Mol Cell Biol 34(14): 2660-2681.
  11. Konopka, J. B. and Thorner, J. W. (2013). Pheromone receptors (Yeast). In: Lennarz, W. J. and Lane, M. D. (eds). The Encyclopedia of Biological Chemistry. Academic Press, 441-446.
  12. O'Donnell, A. F., Huang, L., Thorner, J. and Cyert, M. S. (2013). A calcineurin-dependent switch controls the trafficking function of alpha-arrestin Aly1/Art6. J Biol Chem 288(33): 24063-24080.
  13. de Val, N., McMurray, M. A., Lam, L. H., Hsiung, C. C., Bertin, A., Nogales, E. and Thorner, J. (2013). Native cysteine residues are dispensable for the structure and function of all five yeast mitotic septins. Proteins 81(11): 1964-1979.
  14. Lee, Y. J., Jeschke, G. R., Roelants, F. M., Thorner, J. and Turk, B. E. (2012). Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress. Mol Cell Biol 32(22): 4705-4717.
  15. Wu, H. J., Henzie, J., Lin, W. C., Rhodes, C., Li, Z., Sartorel, E., Thorner, J., Yang, P. and Groves, J. T. (2012). Membrane-protein binding measured with solution-phase plasmonic nanocube sensors. Nat Methods 9(12): 1189-1191.
  16. Bertin, A., McMurray, M. A., Pierson, J., Thai, L., McDonald, K. L., Zehr, E. A., Garcia, G., 3rd, Peters, P., Thorner, J. and Nogales, E. (2012). Three-dimensional ultrastructure of the septin filament network in Saccharomyces cerevisiae. Mol Biol Cell 23(3): 423-432.
  17. Roelants, F. M., Breslow, D. K., Muir, A., Weissman, J. S. and Thorner, J. (2011). Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 108(48): 19222-19227.
  18. Garcia, G., 3rd, Bertin, A., Li, Z., Song, Y., McMurray, M. A., Thorner, J. and Nogales, E. (2011). Subunit-dependent modulation of septin assembly: budding yeast septin Shs1 promotes ring and gauze formation. J Cell Biol 195(6): 993-1004.
  19. McMurray, M. A., Stefan, C. J., Wemmer, M., Odorizzi, G., Emr, S. D. and Thorner, J. (2011). Genetic interactions with mutations affecting septin assembly reveal ESCRT functions in budding yeast cytokinesis. Biol Chem 392(8-9): 699-712.
  20. McMurray, M. A., Bertin, A., Garcia, G., 3rd, Lam, L., Nogales, E. and Thorner, J. (2011). Septin filament formation is essential in budding yeast. Dev Cell 20(4): 540-549.
  21. Lim, S., Strahl, T., Thorner, J. and Ames, J. B. (2011). Structure of a Ca2+-myristoyl switch protein that controls activation of a phosphatidylinositol 4-kinase in fission yeast. J Biol Chem 286(14): 12565-12577.
  22. Patterson, J. C., Klimenko, E. S. and Thorner, J. (2010). Single-cell analysis reveals that insulation maintains signaling specificity between two yeast MAPK pathways with common components. Sci Signal 3(144): ra75.
  23. Bertin, A., McMurray, M. A., Thai, L., Garcia, G., 3rd, Votin, V., Grob, P., Allyn, T., Thorner, J. and Nogales, E. (2010). Phosphatidylinositol-4,5-bisphosphate promotes budding yeast septin filament assembly and organization. J Mol Biol 404(4): 711-731.
  24. Chen, R. E., Patterson, J. C., Goupil, L. S. and Thorner, J. (2010). Dynamic localization of Fus3 mitogen-activated protein kinase is necessary to evoke appropriate responses and avoid cytotoxic effects. Mol Cell Biol 30(17): 4293-4307.
  25. Garrenton, L. S., Stefan, C. J., McMurray, M. A., Emr, S. D. and Thorner, J. (2010). Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling. Proc Natl Acad Sci U S A 107(26): 11805-11810.
  26. Chen, R. E. and Thorner, J. (2010). Systematic epistasis analysis of the contributions of protein kinase A- and mitogen-activated protein kinase-dependent signaling to nutrient limitation-evoked responses in the yeast Saccharomyces cerevisiae. Genetics 185(3): 855-870.
  27. Roelants, F. M., Baltz, A. G., Trott, A. E., Fereres, S. and Thorner, J. (2010). A protein kinase network regulates the function of aminophospholipid flippases. Proc Natl Acad Sci U S A 107(1): 34-39.
Protocols by Jeremy Thorner
  1. Complex in vivo Ligation Using Homologous Recombination and High-efficiency Plasmid Rescue from Saccharomyces cerevisiae