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Nelly Frossard

Education

Ph.D. in Molecular and Cellular Pharmacology, Université Louis Pasteur, Strasbourg I, 1981

Current position

Nelly Frossard is a Co-head of "Integrative Chemical Biology" team 1, Laboratory of Therapeutic Innovation, UMR 7200 CNRS / Strasbourg University (Pr M. Hibert)

Publications

  1. Benahmed, M. A., Elbayed, K., Daubeuf, F., Santelmo, N., Frossard, N. and Namer, I. J. (2014). NMR HRMAS spectroscopy of lung biopsy samples: Comparison study between human, pig, rat, and mouse metabolomics. Magn Reson Med 71(1): 35-43.
  2. Daubeuf, F. and Frossard, N. (2013). Acute asthma models to ovalbumin in the mouse. Curr Protoc Mouse Biol 3: 1-7.
  3. Reber, L. L., Daubeuf, F., Nemska, S. and Frossard, N. (2012). The AGC kinase inhibitor H89 attenuates airway inflammation in mouse models of asthma. PLoS ONE 7(11): e49512.
  4. Reber, L. L., Daubeuf, F., Plantinga, M., De Cauwer, L., Gerlo, S., Waelput, W., Van Calenbergh, S., Tavernier, J., Haegeman, G., Lambrecht, B. N., Frossard, N.* and De Bosscher, K.* (2012). A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma. J Immunol 188(7): 3478-3487. (*equivalent last author)
  5. Gasparik, V., Daubeuf, F., Hachet-Haas, M., Rohmer, F., Gizzi, P., Haiech, J., Galzi, J. L., Hibert, M., Bonnet, D. and Frossard, N. (2012). Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo. ACS Med Chem Lett 3(1): 10-14.
  6. Daubeuf, F. and Frossard, N. (2012). Performing bronchoalveolar lavage in the mouse. Curr Protoc Mouse Biol 2: 1-8.
  7. (2012). Why and how to find neutraligands targeting chemokines? Drug Discov Today Technol 9(4): e227-314.
  8. Freund-Michel, V., Muller, B. and Frossard, N. (2011). Expression and role of the TrkA receptor in pulmonary inflammatory diseases. In “Inflammatory diseases – A modern perspective”, In: Amit Nagal(eds), InTech publisher, pp. 75-100.
  9. Benahmed, M. A., Santelmo, N., Elbayed, K., Frossard, N., Noll, E., Canuet, M., Pottecher, J., Diemunsch, P., Piotto, M., Massard, G. and Namer, I. J. (2012). The assessment of the quality of the graft in an animal model for lung transplantation using the metabolomics 1H high-resolution magic angle spinning NMR spectroscopy. Magn Reson Med 68(4): 1026-1038.
  10. Deschamps, K., Cromlish, W., Weicker, S., Lamontagne, S., Huszar, S. L., Gauthier, J. Y., Mudgett, J. S., Guimond, A., Romand, R., Frossard, N., Percival, M. D., Slipetz, D. and Tan, C. M. (2011). Genetic and pharmacological evaluation of cathepsin s in a mouse model of asthma. Am J Respir Cell Mol Biol 45(1): 81-87.
  11. Hachet-Haas, M., Bonnet, D., Daubeuf, F., Hibert, M., Haiech, J., Frossard, N. and Galzi , J. L.(2011). Les neutraligands à l’assaut des chimiokines. Biofutur, 30/319, 52-55.
  12. Galzi, J. L., Hachet-Haas, M., Bonnet, D., Daubeuf, F., Lecat, S., Hibert, M., Haiech, J. and Frossard, N. (2010). Neutralizing endogenous chemokines with small molecules. Principles and potential therapeutic applications. Pharmacol Ther 126(1): 39-55.
  13. Reber, L., Vermeulen, L., Haegemann, G. and Frossard, N. (2009) Mitogen- and Stress-activated protein Kinase (MSK)1-mediated NFkB phosphorylation is necessary for IL-1β-induced stem cell factor (SCF) expression. PloS One 4(2):e4393.
  14. Zhang, Z., Hener, P., Frossard, N., Kato, S., Metzger, D., Li, M. and Chambon, P. (2009). Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proc Natl Acad Sci U S A 106(5): 1536-1541.
  15. Freund-Michel, V. and Frossard, N. (2008). Overexpression of functional TrkA receptors after internalisation in human airway smooth muscle cells. Biochim Biophys Acta 1783(10): 1964-1971.
  16. Freund-Michel, V. and Frossard, N. (2008). The nerve growth factor and its receptors in airway inflammatory diseases. Pharmacol Ther 117(1): 52-76.
  17. Ble, F. X., Cannet, C., Zurbruegg, S., Karmouty-Quintana, H., Bergmann, R., Frossard, N., Trifilieff, A. and Beckmann, N. (2008). Allergen-induced lung inflammation in actively sensitized mice assessed with MR imaging. Radiology 248(3): 834-843.
  18. Hachet-Haas, M., Balabanian, K., Rohmer, F., Pons, F., Franchet, C., Lecat, S., Chow, K. Y., Dagher, R., Gizzi, P., Didier, B., Lagane, B., Kellenberger, E., Bonnet, D., Baleux, F., Haiech, J., Parmentier, M., Frossard, N., Arenzana-Seisdedos, F., Hibert, M. and Galzi, J. L. (2008). Small neutralizing molecules to inhibit actions of the chemokine CXCL12. J Biol Chem 283(34): 23189-23199.
Protocols by Nelly Frossard
  1. Measurement of Airway Responsiveness on Vigil and Unrestrained Mouse
  2. Allergen Sensitization and Challenge to Ovalbumin
  3. Measurement of Airway Responsiveness in the Anesthetized Mouse