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Guoping Ren

Education

Ph.D., Institute of Biophysics, CAS, Beijing, China

Current position

Postdoc, New England Biolabs Inc. (since 2015)

Publications

  1. Ren, G., Champion, M. M. and Huntley, J. F. (2014). Identification of disulfide bond isomerase substrates reveals bacterial virulence factors. Mol Microbiol 94(4): 926-944.
  2. Quan, S., Koldewey, P., Tapley, T., Kirsch, N., Ruane, K. M., Pfizenmaier, J., Shi, R., Hofmann, S., Foit, L., Ren, G., Jakob, U., Xu, Z., Cygler, M. and Bardwell, J. C. (2011). Genetic selection designed to stabilize proteins uncovers a chaperone called Spy. Nat Struct Mol Biol 18(3): 262-269.
    Note: This paper was the subject of a News and Views in Nature: Powers, E. T. and Balch, W. E. (2011). Protein folding: Protection from the outside. Nature 471(7336): 42-43.
  3. Ren, G. and Bardwell, J. C. (2011). Engineered pathways for correct disulfide bond oxidation. Antioxid Redox Signal 14(12): 2399-2412.
  4. Foit, L.*, Mueller-Schickert, A.*, Mamathambika, B. S., Gleiter, S., Klaska, C. L., Ren, G. and Bardwell, J. C. (2011). Genetic selection for enhanced folding in vivo targets the Cys14-Cys38 disulfide bond in bovine pancreatic trypsin inhibitor. Antioxid Redox Signal 14(6): 973-984.
  5. Li, H.*, Ke, H.*, Ren, G., Qiu, X., Weng, Y. X. and Wang, C. C. (2009). Thermal-induced dissociation and unfolding of homodimeric DsbC revealed by temperature-jump time-resolved infrared spectra. Biophys J 97(10): 2811-2819.
  6. Ren, G., Stephan, D., Xu, Z., Zheng, Y., Tang, D., Harrison, R. S., Kurz, M., Jarrott, R., Shouldice, S. R., Hiniker, A., Martin, J. L., Heras, B. and Bardwell, J. C. (2009). Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue. J Biol Chem 284(15): 10150-10159.
  7. Hiniker, A., Ren, G., Heras, B., Zheng, Y., Laurinec, S., Jobson, R. W., Stuckey, J. A., Martin, J. L. and Bardwell, J. C. (2007). Laboratory evolution of one disulfide isomerase to resemble another. Proc Natl Acad Sci U S A 104(28): 11670-11675.
  8. Ren, G.*, Wang, X.*, Hao, S., Hu, H. and Wang, C. C. (2007). Translocation of alpha-synuclein expressed in Escherichia coli. J Bacteriol 189(7): 2777-2786.
  9. Huang, C., Ren, G., Zhou, H. and Wang, C. C. (2005). A new method for purification of recombinant human alpha-synuclein in Escherichia coli. Protein Expr Purif 42(1): 173-177.
  10. Ren, G., Lin, Z., Tsou, C. L. and Wang, C. C. (2003). Effects of macromolecular crowding on the unfolding and the refolding of D-glyceraldehyde-3-phosophospate dehydrogenase. J Protein Chem 22(5): 431-439.
    *Contributed equally
Protocols by Guoping Ren
  1. Generating Isogenic Deletions (Knockouts) in Francisella tularensis, a Highly-infectious and Fastidious Gram-negative Bacterium