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Matthew C. Strain


M. D., University of California San Diego, 2005
Ph.D. in Physics, University of California San Diego, 2002

Current position

Assistant Professor, Division of Infectious Diseases, UCSD (2014-present)
Associate Director, Genomics & Sequencing Core, UCSD Center for AIDS Research (2014-present)


  1. Strain, M. C., Lada, S. M., Luong, T., Rought, S. E., Gianella, S., Terry, V. H., Spina, C. A., Woelk, C. H. and Richman, D. D. (2013). Highly precise measurement of HIV DNA by droplet digital PCR. PLoS One 8(4): e55943.
  2. Strain, M. C. and Richman, D. D. (2013). New assays for monitoring residual HIV burden in effectively treated individuals. Curr Opin HIV AIDS 8(2): 106-110.
  3. Yukl, S. A., Boritz, E., Busch, M., Bentsen, C., Chun, T. W., Douek, D., Eisele, E., Haase, A., Ho, Y. C., Hutter, G., Justement, J. S., Keating, S., Lee, T. H., Li, P., Murray, D., Palmer, S., Pilcher, C., Pillai, S., Price, R. W., Rothenberger, M., Schacker, T., Siliciano, J., Siliciano, R., Sinclair, E., Strain, M., Wong, J., Richman, D. and Deeks, S. G. (2013). Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. PLoS Pathog 9(5): e1003347.
  4. Eriksson, S., Graf, E. H., Dahl, V., Strain, M. C., Yukl, S. A., Lysenko, E. S., Bosch, R. J., Lai, J., Chioma, S., Emad, F., Abdel-Mohsen, M., Hoh, R., Hecht, F., Hunt, P., Somsouk, M., Wong, J., Johnston, R., Siliciano, R. F., Richman, D. D., O'Doherty, U., Palmer, S., Deeks, S. G. and Siliciano, J. D. (2013). Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLoS Pathog 9(2): e1003174.
  5. Persaud, D., Gay, H., Ziemniak, C., Chen, Y. H., Piatak, M., Jr., Chun, T. W., Strain, M., Richman, D. and Luzuriaga, K. (2013). Absence of detectable HIV-1 viremia after treatment cessation in an infant. N Engl J Med 369(19): 1828-1835.
  6. Archin, N. M., Liberty, A. L., Kashuba, A. D., Choudhary, S. K., Kuruc, J. D., Crooks, A. M., Parker, D. C., Anderson, E. M., Kearney, M. F., Strain, M. C., Richman, D. D., Hudgens, M. G., Bosch, R. J., Coffin, J. M., Eron, J. J., Hazuda, D. J. and Margolis, D. M. (2012). Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature 487(7408): 482-485.
  7. Yukl, S., Pillai, S., Li, P., Chang, K., Pasutti, W., Ahlgren, C., Havlir, D., Strain, M., Gunthard, H., Richman, D., Rice, A. P., Daar, E., Little, S. and Wong, J. K. (2009). Latently-infected CD4+ T cells are enriched for HIV-1 Tat variants with impaired transactivation activity. Virology 387(1): 98-108.
  8. Strain, M. C., Little, S. J., Daar, E. S., Havlir, D. V., Gunthard, H. F., Lam, R. Y., Daly, O. A., Nguyen, J., Ignacio, C. C., Spina, C. A., Richman, D. D. and Wong, J. K. (2005). Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1. J Infect Dis 191(9): 1410-1418.
  9. Havlir, D. V., Koelsch, K. K., Strain, M. C., Margot, N., Lu, B., Ignacio, C. C., Miller, M. D., Wong, J. K. and Gilead 903 Study, T. (2005). Predictors of residual viremia in HIV-infected patients successfully treated with efavirenz and lamivudine plus either tenofovir or stavudine. J Infect Dis 191(7): 1164-1168.
  10. Strain, M. C., Gunthard, H. F., Havlir, D. V., Ignacio, C. C., Smith, D. M., Leigh-Brown, A. J., Macaranas, T. R., Lam, R. Y., Daly, O. A., Fischer, M., Opravil, M., Levine, H., Bacheler, L., Spina, C. A., Richman, D. D. and Wong, J. K. (2003). Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence. Proc Natl Acad Sci U S A 100(8): 4819-4824.
Protocols by Matthew C. Strain
  1. Quantification of Total and 2-LTR (Long terminal repeat) HIV DNA, HIV RNA and Herpesvirus DNA in PBMCs