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Lucia Mori


Ph.D. in Microbiology, University of Pisa, Italy, 1987

Current position

Principal Investigator, Singapore Immunology Network (SIgN), Biomedical Research Council, Agency for Science, Technology & Research (A*STAR), Singapore (since 2010)
Principal Investigator, Experimental Immunology, Department of Biomedicine, Basel University Hospital, Switzerland (since 2015)

Publications (since 2010)

Articles in peer-reviewed journals

  1. Cavallari, M., Stallforth, P., Kalinichenko, A., Rathwell, D. C., Gronewold, T. M., Adibekian, A., Mori, L., Landmann, R., Seeberger, P. H. and De Libero, G. (2014). A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice. Nat Chem Biol 10(11): 950-956.
  2. Lepore, M., de Lalla, C., Gundimeda, S. R., Gsellinger, H., Consonni, M., Garavaglia, C., Sansano, S., Piccolo, F., Scelfo, A., Haussinger, D., Montagna, D., Locatelli, F., Bonini, C., Bondanza, A., Forcina, A., Li, Z., Ni, G., Ciceri, F., Jeno, P., Xia, C., Mori, L., Dellabona, P., Casorati, G. and De Libero, G. (2014). A novel self-lipid antigen targets human T cells against CD1c(+) leukemias. J Exp Med 211(7): 1363-1377.
  3. Lepore, M., Kalinichenko, A., Colone, A., Paleja, B., Singhal, A., Tschumi, A., Lee, B., Poidinger, M., Zolezzi, F., Quagliata, L., Sander, P., Newell, E., Bertoletti, A., Terracciano, L., De Libero, G. and Mori, L. (2014). Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRbeta repertoire. Nat Commun 5: 3866.
  4. Moinuddeen, S. K. (2013). Hybrid polymersomes: facile manipulation of vesicular surfaces for enhancing cellular interaction. Journal of Materials Chemistry B 1(42): 5751-5755.
  5. Gau, B., Lemetais, A., Lepore, M., Garcia-Alles, L. F., Bourdreux, Y., Mori, L., Gilleron, M., De Libero, G., Puzo, G., Beau, J. M. and Prandi, J. (2013). Simplified deoxypropionate acyl chains for Mycobacterium tuberculosis sulfoglycolipid analogues: chain length is essential for high antigenicity. Chembiochem 14(18): 2413-2417.
  6. Vavassori, S., Kumar, A., Wan, G. S., Ramanjaneyulu, G. S., Cavallari, M., El Daker, S., Beddoe, T., Theodossis, A., Williams, N. K., Gostick, E., Price, D. A., Soudamini, D. U., Voon, K. K., Olivo, M., Rossjohn, J., Mori, L. and De Libero, G. (2013). Butyrophilin 3A1 binds phosphorylated antigens and stimulates human gammadelta T cells. Nat Immunol 14(9): 908-916.
  7. Geerdink, D., ter Horst, B., Lepore, M., Mori, L., Puzo, G., Hirsch, A. K., Gilleron, M., de Libero, G. and Minnaard, A. J. (2013). Total synthesis, stereochemical elucidation and biological evaluation of Ac 2 SGL; a 1, 3-methyl branched sulfoglycolipid from Mycobacterium tuberculosis. Chemical Science 4(2): 709-716.
  8. Cala-De Paepe, D., Layre, E., Giacometti, G., Garcia-Alles, L. F., Mori, L., Hanau, D., de Libero, G., de la Salle, H., Puzo, G. and Gilleron, M. (2012). Deciphering the role of CD1e protein in mycobacterial phosphatidyl-myo-inositol mannosides (PIM) processing for presentation by CD1b to T lymphocytes. J Biol Chem 287(37): 31494-31502.
  9. Facciotti, F., Ramanjaneyulu, G. S., Lepore, M., Sansano, S., Cavallari, M., Kistowska, M., Forss-Petter, S., Ni, G., Colone, A., Singhal, A., Berger, J., Xia, C., Mori, L. and De Libero, G. (2012). Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus. Nat Immunol 13(5): 474-480.
  10. Garcia-Alles, L. F., Collmann, A., Versluis, C., Lindner, B., Guiard, J., Maveyraud, L., Huc, E., Im, J. S., Sansano, S., Brando, T., Julien, S., Prandi, J., Gilleron, M., Porcelli, S. A., de la Salle, H., Heck, A. J., Mori, L., Puzo, G., Mourey, L. and De Libero, G. (2011). Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids. Proc Natl Acad Sci U S A 108(43): 17755-17760.
  11. Facciotti, F., Cavallari, M., Angenieux, C., Garcia-Alles, L. F., Signorino-Gelo, F., Angman, L., Gilleron, M., Prandi, J., Puzo, G., Panza, L., Xia, C., Wang, P. G., Dellabona, P., Casorati, G., Porcelli, S. A., de la Salle, H., Mori, L. and De Libero, G. (2011). Fine tuning by human CD1e of lipid-specific immune responses. Proc Natl Acad Sci U S A 108(34): 14228-14233.
  12. Cillo, C., Schiavo, G., Cantile, M., Bihl, M. P., Sorrentino, P., Carafa, V., M, D. A., Roncalli, M., Sansano, S., Vecchione, R., Tornillo, L., Mori, L., De Libero, G., Zucman-Rossi, J. and Terracciano, L. (2011). The HOX gene network in hepatocellular carcinoma. Int J Cancer 129(11): 2577-2587.
  13. Garcia-Alles, L. F., Giacometti, G., Versluis, C., Maveyraud, L., de Paepe, D., Guiard, J., Tranier, S., Gilleron, M., Prandi, J., Hanau, D., Heck, A. J., Mori, L., De Libero, G., Puzo, G., Mourey, L. and de la Salle, H. (2011). Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes. Proc Natl Acad Sci U S A 108(32): 13230-13235.
  14. de Lalla, C., Lepore, M., Piccolo, F. M., Rinaldi, A., Scelfo, A., Garavaglia, C., Mori, L., De Libero, G., Dellabona, P. and Casorati, G. (2011). High-frequency and adaptive-like dynamics of human CD1 self-reactive T cells. Eur J Immunol 41(3): 602-610.
  15. Kyriakakis, E., Cavallari, M., Andert, J., Philippova, M., Koella, C., Bochkov, V., Erne, P., Wilson, S. B., Mori, L., Biedermann, B. C., Resink, T. J. and De Libero, G. (2010). Invariant natural killer T cells: linking inflammation and neovascularization in human atherosclerosis. Eur J Immunol 40(11): 3268-3279.
  16. Cernadas, M., Cavallari, M., Watts, G., Mori, L., De Libero, G. and Brenner, M. B. (2010). Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens. J Immunol 184(3): 1235-1241.
Protocols by Lucia Mori
  1. Extraction and Identification of T Cell Stimulatory Self-lipid Antigens