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Claudia de Lalla

Education

Ph.D. in Biology, Università Statale Milano, Italy, 1985

Current position

Senior Scientist, Ospedale San Raffaele Milano- Italy, DIBIT (since1993)

Publications (since 2000)

  1. Lepore, M., de Lalla, C., Mori, L., Dellabona, P., De Libero, G. and Casorati, G. (2015). Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen. Oncoimmunology 4(3): e970463.
  2. Lepore, M., de Lalla, C., Gundimeda, S. R., Gsellinger, H., Consonni, M., Garavaglia, C., Sansano, S., Piccolo, F., Scelfo, A., Haussinger, D., Montagna, D., Locatelli, F., Bonini, C., Bondanza, A., Forcina, A., Li, Z., Ni, G., Ciceri, F., Jeno, P., Xia, C., Mori, L., Dellabona, P., Casorati, G. and De Libero, G. (2014). A novel self-lipid antigen targets human T cells against CD1c(+) leukemias. J Exp Med 211(7): 1363-1377.
  3. Casorati, G., de Lalla, C. and Dellabona, P. (2012). Invariant natural killer T cells reconstitution and the control of leukemia relapse in pediatric haploidentical hematopoietic stem cell transplantation. Oncoimmunology 1(3): 355-357.
  4. Dellabona, P., Casorati, G., de Lalla, C., Montagna, D. and Locatelli, F. (2011). On the use of donor-derived iNKT cells for adoptive immunotherapy to prevent leukemia recurrence in pediatric recipients of HLA haploidentical HSCT for hematological malignancies. Clin Immunol 140(2): 152-159.
  5. de Lalla, C., Lepore, M., Piccolo, F. M., Rinaldi, A., Scelfo, A., Garavaglia, C., Mori, L., De Libero, G., Dellabona, P. and Casorati, G. (2011). High-frequency and adaptive-like dynamics of human CD1 self-reactive T cells. Eur J Immunol 41(3): 602-610.
  6. de Lalla, C., Rinaldi, A., Montagna, D., Azzimonti, L., Bernardo, M. E., Sangalli, L. M., Paganoni, A. M., Maccario, R., Di Cesare-Merlone, A., Zecca, M., Locatelli, F., Dellabona, P. and Casorati, G. (2011). Invariant NKT cell reconstitution in pediatric leukemia patients given HLA-haploidentical stem cell transplantation defines distinct CD4+ and CD4- subset dynamics and correlates with remission state. J Immunol 186(7): 4490-4499.
  7. Fallarini, S., Magliulo, L., Paoletti, T., de Lalla, C. and Lombardi, G. (2010). Expression of functional GPR35 in human iNKT cells. Biochem Biophys Res Commun 398(3): 420-425.
  8. Fedeli, M., Napolitano, A., Wong, M. P., Marcais, A., de Lalla, C., Colucci, F., Merkenschlager, M., Dellabona, P. and Casorati, G. (2009). Dicer-dependent microRNA pathway controls invariant NKT cell development. J Immunol 183(4): 2506-2512.
  9. de Lalla, C., Festuccia, N., Albrecht, I., Chang, H. D., Andolfi, G., Benninghoff, U., Bombelli, F., Borsellino, G., Aiuti, A., Radbruch, A., Dellabona, P. and Casorati, G. (2008). Innate-like effector differentiation of human invariant NKT cells driven by IL-7. J Immunol 180(7): 4415-4424.
  10. Thedrez, A., de Lalla, C., Allain, S., Zaccagnino, L., Sidobre, S., Garavaglia, C., Borsellino, G., Dellabona, P., Bonneville, M., Scotet, E. and Casorati, G. (2007). CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells. Blood 110(1): 251-258.
  11. de Lalla, C., Galli, G., Aldrighetti, L., Romeo, R., Mariani, M., Monno, A., Nuti, S., Colombo, M., Callea, F., Porcelli, S. A., Panina-Bordignon, P., Abrignani, S., Casorati, G. and Dellabona, P. (2004). Production of profibrotic cytokines by invariant NKT cells characterizes cirrhosis progression in chronic viral hepatitis. J Immunol 173(2): 1417-1425.
  12. Galli, G., Nuti, S., Tavarini, S., Galli-Stampino, L., De Lalla, C., Casorati, G., Dellabona, P. and Abrignani, S. (2003). Innate immune responses support adaptive immunity: NKT cells induce B cell activation. Vaccine 21 Suppl 2: S48-54.
  13. Galli, G., Nuti, S., Tavarini, S., Galli-Stampino, L., De Lalla, C., Casorati, G., Dellabona, P. and Abrignani, S. (2003). CD1d-restricted help to B cells by human invariant natural killer T lymphocytes. J Exp Med 197(8): 1051-1057.
  14. Turatti, F., Mezzanzanica, D., Nardini, E., Luison, E., Maffioli, L., Bambardieri, E., de Lalla, C., Canevari, S. and Figini, M. (2001). Production and validation of the pharmacokinetics of a single-chain Fv fragment of the MGR6 antibody for targeting of tumors expressing HER-2. Cancer Immunol Immunother 49(12): 679-686.
  15. D'Andrea, A., Goux, D., De Lalla, C., Koezuka, Y., Montagna, D., Moretta, A., Dellabona, P., Casorati, G. and Abrignani, S. (2000). Neonatal invariant Valpha24+ NKT lymphocytes are activated memory cells. Eur J Immunol 30(6): 1544-1550.
Protocols by Claudia de Lalla
  1. Extraction and Identification of T Cell Stimulatory Self-lipid Antigens