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Jennifer Hirst

Education

Ph.D. in Cell Biology, University College London, UK, 1994

Current position

Principal Research Associate, Department of Clinical Biochemistry, CIMR, Wellcome Trust/MRC Building, Addenbrooke’s Hospital, Cambridge, UK

Publications (since 2010)

  1. Hardies, K., May, P., Djemie, T., Tarta-Arsene, O., Deconinck, T., Craiu, D., Consortium, A. R. w. g. o. t. E. R., Helbig, I., Suls, A., Balling, R., Weckhuysen, S., De Jonghe, P. and Hirst, J. (2015). Recessive loss-of-function mutations in AP4S1 cause mild fever-sensitive seizures, developmental delay and spastic paraplegia through loss of AP-4 complex assembly. Hum Mol Genet 24(8): 2218-2227.
  2. Zhang, Y., Persson, S., Hirst, J., Robinson, M. S., van Damme, D. and Sanchez-Rodriguez, C. (2015). Change your TPLATE, change your fate: plant CME and beyond. Trends Plant Sci 20(1): 41-48.
  3. Borner, G. H., Hein, M. Y., Hirst, J., Edgar, J. R., Mann, M. and Robinson, M. S. (2014). Fractionation profiling: a fast and versatile approach for mapping vesicle proteomes and protein-protein interactions. Mol Biol Cell 25(20): 3178-3194.
  4. Hirst, J., Schlacht, A., Norcott, J. P., Traynor, D., Bloomfield, G., Antrobus, R., Kay, R. R., Dacks, J. B. and Robinson, M. S. (2014). Characterization of TSET, an ancient and widespread membrane trafficking complex. Elife 3: e02866.
  5. Robinson, M. S. and Hirst, J. (2013). Rapid inactivation of proteins by knocksideways. Curr Protoc Cell Biol 61: 15 20 11-17.
  6. Hirst, J., Borner, G. H., Edgar, J., Hein, M. Y., Mann, M., Buchholz, F., Antrobus, R. and Robinson, M. S. (2013). Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15. Mol Biol Cell 24(16): 2558-2569.
  7. Hirst, J., Irving, C. and Borner, G. H. (2013). Adaptor protein complexes AP-4 and AP-5: new players in endosomal trafficking and progressive spastic paraplegia. Traffic 14(2): 153-164.
  8. Kong, X. F., Bousfiha, A., Rouissi, A., Itan, Y., Abhyankar, A., Bryant, V., Okada, S., Ailal, F., Bustamante, J., Casanova, J. L., Hirst, J. and Boisson-Dupuis, S. (2013). A novel homozygous p.R1105X mutation of the AP4E1 gene in twins with hereditary spastic paraplegia and mycobacterial disease. PLoS One 8(3): e58286.
  9. Pohler, E., Mamai, O., Hirst, J., Zamiri, M., Horn, H., Nomura, T., Irvine, A. D., Moran, B., Wilson, N. J., Smith, F. J., Goh, C. S., Sandilands, A., Cole, C., Barton, G. J., Evans, A. T., Shimizu, H., Akiyama, M., Suehiro, M., Konohana, I., Shboul, M., Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Brown, S. J., Goudie, D. R., Reversade, B., Munro, C. S. and McLean, W. H. (2012). Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma. Nat Genet 44(11): 1272-1276.
  10. Hirst, J., Borner, G. H., Antrobus, R., Peden, A. A., Hodson, N. A., Sahlender, D. A. and Robinson, M. S. (2012). Distinct and overlapping roles for AP-1 and GGAs revealed by the "knocksideways" system. Curr Biol 22(18): 1711-1716.
  11. Borner, G. H., Antrobus, R., Hirst, J., Bhumbra, G. S., Kozik, P., Jackson, L. P., Sahlender, D. A. and Robinson, M. S. (2012). Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles. J Cell Biol 197(1): 141-160.
  12. Hirst, J., Barlow, L. D., Francisco, G. C., Sahlender, D. A., Seaman, M. N., Dacks, J. B. and Robinson, M. S. (2011). The fifth adaptor protein complex. PLoS Biol 9(10): e1001170.
  13. Hirst, J. and Carmichael, J. (2011). A potential role for the clathrin adaptor GGA in Drosophila spermatogenesis. BMC Cell Biol 12: 22.
Protocols by Jennifer Hirst
  1. Dictyostelium Cultivation, Transfection, Microscopy and Fractionation