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Mike Z Lin


Ph.D. in Medicine, University of New South Wales, 2007

Current position

Research Fellow, Kolling Institute of Medical Research, Royal North Shore Hospital, the University of Sydney (2007-present)


Selected Publications in Peer-Reviewed Journals

  1. Lin, M. Z., Marzec, K. A., Martin, J. L. and Baxter, R. C. (2014). The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents. Oncogene 33(1): 85-96.
  2. Martin, J. L., de Silva, H. C., Lin, M. Z., Scott, C. D. and Baxter, R. C. (2014). Inhibition of insulin-like growth factor-binding protein-3 signaling through sphingosine kinase-1 sensitizes triple-negative breast cancer cells to EGF receptor blockade. Mol Cancer Ther 13(2): 316-328.
  3. Leong, S., Nunez, A. C., Lin, M. Z., Crossett, B., Christopherson, R. I. and Baxter, R. C. (2012). iTRAQ-based proteomic profiling of breast cancer cell response to doxorubicin and TRAIL. J Proteome Res 11(7): 3561-3572.
  4. De Bock, C. E.*, Lin, Z.*, Mekkawy, A. H., Byrne, J. A. and Wang, Y. (2010). Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion. Int J Oncol 36(5): 1155-1163. (*These authors contributed equally to this work)
  5. Mekkawy, A. H., De Bock, C. E., Lin, Z., Morris, D. L., Wang, Y. and Pourgholami, M. H. (2010). Novel protein interactors of urokinase-type plasminogen activator receptor. Biochem Biophys Res Commun 399(4): 738-743.
  6. Martin, J. L., Lin, M. Z., McGowan, E. M. and Baxter, R. C. (2009). Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity. J Biol Chem 284(38): 25542-25552.
  7. Wei, A., Chung, S. A., Tao, H., Brisby, H., Lin, Z., Shen, B., Ma, D. D. and Diwan, A. D. (2009). Differentiation of rodent bone marrow mesenchymal stem cells into intervertebral disc-like cells following coculture with rat disc tissue. Tissue Eng Part A 15(9): 2581-2595.
  8. de Bock, C. E.*, Lin, Z.*, Itoh, T., Morris, D., Murrell, G. and Wang, Y. (2005). Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells. FEBS J 272(14): 3572-3582. (*Contributed equally)
  9. Zhu, S., Chen, S., Li, Q., Lin, Z., Zheng, S. and Weng, M. (2004). Serum PSA and transition zone index as predictors of acute urinary retention in benign prostate hyperplasia. Zhonghua Nan Ke Xue 10(1): 24-25.
  10. Lin, Z., Chen, S., Ye, C. and Zhu, S. (2003). Nitric oxide synthase expression in human bladder cancer and its relation to angiogenesis. Urological Res 31(4): 232-235.
  11. Ye, C. Z., Zhao, X. D., Zhang, F. L., Lin, Z., Xu, M., Zhang, Y. K. and Chen, C. Q. (2002). Cloning and expression of extracellular domain of prostate specific membrane antigen in Escherichia coli and preparation of polyclonal antibody. Sheng Wu Gong Cheng Xue Bao 18(1): 35-39.
  12. Chuanzhong, Y., Ming, G., Fanglin, Z., Haijiao, C., Zhen, L., Shiping, C. and YongKang, Z. (2002). Real-time quantitative reverse transcription-PCR assay for renal cell carcinoma-associated antigen G250. Clin Chim Acta 318(1-2): 33-40.
  13. Chen, S., Lin, Z., Chen, W. et al. (2002). A model establishment of combined pancreas-kidney transplantation in dog. Journal of Chinese Physician (9): 963-5.
  14. Ye, C., Lin, Z., Chen, S., Zhang, F., Pei, X., Li, L. and Feng, K. (2000). The construction of bicistronic eukaryotic vector carrying green fluorescent protein and hytk gene and its expression in bladder carcinoma. Chinese Journal of Pathophysiology 17(9): 825-829.
  15. Lin, Z., Chen, S., Yang, F. et al. (2000). Expression of TGFβ receptor I, II in human transitional cell carcinomas. Chinese Journal of Urology (11): 69413
  16. Lin, Z., Chen, S., Zheng, S. and Xu, E. (1999). Atypical pheochromocytoma. Zhonghua Wai Ke Za Zhi 37(11): 674-676.
  17. Lin, Z., Chen, S. and Ye, C. (1998). Surgical treatment of perplexing renal cell carcinoma. Zhonghua Zhong Liu Za Zhi 20(6): 463-464.
  18. Chen, S., Lin, Z., Ye, C. and Xu, E. (1996). Long-term results of intravesical N-CWS therapy for preventing bladder cancer recurrence after operation. Chin Med J (Engl) 109(11): 890-891.
Protocols by Mike Z Lin
  1. Proximity Ligation Assay (PLA) to Detect Protein-protein Interactions in Breast Cancer