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Yutaka Koyama


Ph.D. in Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Osaka University, 1994

Current position

Professor, Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Japan

Publications (since 2005)

  1. Nakamoto, K., Nishinaka, T., Sato, N., Aizawa, F., Yamashita, T., Mankura, M., Koyama, Y., Kasuya, F. and Tokuyama, S. (2015). The activation of supraspinal GPR40/FFA1 receptor signalling regulates the descending pain control system. Br J Pharmacol 172(5): 1250-1262.
  2. Koyama, Y. (2014). Signaling molecules regulating phenotypic conversions of astrocytes and glial scar formation in damaged nerve tissues. Neurochem Int 78: 35-42.
  3. Koyama, Y., Hayashi, M., Nagae, R., Tokuyama, S. and Konishi, T. (2014). Endothelin-1 increases the expression of VEGF-R1/Flt-1 receptors in rat cultured astrocytes through ETB receptors. J Neurochem 130(6): 759-769.
  4. Michinaga, S., Nagase, M., Matsuyama, E., Yamanaka, D., Seno, N., Fuka, M., Yamamoto, Y. and Koyama, Y. (2014). Amelioration of cold injury-induced cortical brain edema formation by selective endothelin ETB receptor antagonists in mice. PLoS One 9(7): e102009.
  5. Koyama, Y., Kotani, M., Sawamura, T., Kuribayashi, M., Konishi, R. and Michinaga, S. (2013). Different actions of endothelin-1 on chemokine production in rat cultured astrocytes: reduction of CX3CL1/fractalkine and an increase in CCL2/MCP-1 and CXCL1/CINC-1. J Neuroinflammation 10: 51.
  6. Koyama, Y. (2013). Endothelin systems in the brain: involvement in pathophysiological responses of damaged nerve tissues. Biomol Concepts 4(4): 335-347.
  7. Michinaga, S., Ishida, A., Takeuchi, R. and Koyama, Y. (2013). Endothelin-1 stimulates cyclin D1 expression in rat cultured astrocytes via activation of Sp1. Neurochem Int 63(1): 25-34.
  8. Nakamoto, K., Nishinaka, T., Sato, N., Mankura, M., Koyama, Y., Kasuya, F. and Tokuyama, S. (2013). Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatory chronic pain. PLoS One 8(12): e81563.
  9. Koyama, Y., Maebara, Y., Hayashi, M., Nagae, R., Tokuyama, S. and Michinaga, S. (2012). Endothelins reciprocally regulate VEGF-A and angiopoietin-1 production in cultured rat astrocytes: implications on astrocytic proliferation. Glia 60(12): 1954-1963.
  10. Nakamoto, K., Nishinaka, T., Matsumoto, K., Kasuya, F., Mankura, M., Koyama, Y. and Tokuyama, S. (2012). Involvement of the long-chain fatty acid receptor GPR40 as a novel pain regulatory system. Brain Res 1432: 74-83.
  11. Koyama, Y. and Michinaga, S. (2012). Regulations of astrocytic functions by endothelins: roles in the pathophysiological responses of damaged brains. J Pharmacol Sci 118(4): 401-407.
  12. Koyama, Y., Nagae, R., Tokuyama, S. and Tanaka, K. (2011). I.c.v administration of an endothelin ET(B) receptor agonist stimulates vascular endothelial growth factor-A production and activates vascular endothelial growth factor receptors in rat brain. Neuroscience 192: 689-698.
  13. Tanaka, K. and Koyama, Y. (2011). Endothelins decrease the expression of aquaporins and plasma membrane water permeability in cultured rat astrocytes. J Neurosci Res 89(3): 320-328.
  14. Koyama, Y. and Tanaka, K. (2010). Decreases in rat brain aquaporin-4 expression following intracerebroventricular administration of an endothelin ET B receptor agonist. Neurosci Lett 469(3): 343-347.
  15. Koyama, Y. and Tanaka, K. (2010). Intracerebroventricular administration of an endothelin ETB-receptor agonist increases expression of matrix Metalloproteinase-2 and -9 in rat brain. J Pharmacol Sci 114:433-443.
  16. Hosoi, R., Matsuyama, Y., Hirose, S., Koyama, Y., Matsuda, T., Gee, A. and Inoue, O. (2009). Characterization of (14)C-acetate uptake in cultured rat astrocytes. Brain Res 1253: 69-73.
  17. Koyama, Y. and Tanaka, K. (2008). Endothelins stimulate the production of stromelysin-1 in cultured rat astrocytes. Biochem Biophys Res Commun 371(4): 659-663.
  18. Koyama, Y. (2007). Basic research for astrocyte-kinetic drugs. Advances in Pharmaceutical Research 23:5-12
  19. Koyama, Y., Baba, A. and Matsuda, T. (2007). Production of monocyte chemoattractant protein-1 and cytokine-induced neutrophil chemoattractant-1 in rat brain is stimulated by intracerebroventricular administration of an endothelin ETB receptor agonist. Neuroreport 18(12): 1275-1279.
  20. Koyama, Y., Baba, A. and Matsuda, T. (2007). Intracerebroventricular administration of an endothelin ETB receptor agonist increases expression of tissue inhibitor of matrix metalloproteinase-1 and -3 in rat brain. Neuroscience 147(3): 620-630.
  21. Koyama, Y., Kiyo-oka, M., Osakada, M., Horiguchi, N., Shintani, N., Ago, Y., Kakuda, M., Baba, A. and Matsuda, T. (2006). Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell proliferation. Brain Res 1112(1): 65-69.
  22. Nakamura, S., Ago, Y., Itoh, S., Koyama, Y., Baba, A. and Matsuda, T. (2005). Effect of zotepine on dopamine, serotonin and noradrenaline release in rat prefrontal cortex. Eur J Pharmacol 528(1-3): 95-98.
  23. Koyama, Y., Baba, A. and Matsuda, T. (2005). Endothelins stimulate the expression of neurotrophin-3 in rat brain and rat cultured astrocytes. Neuroscience 136(2): 425-433.
  24. Koyama, Y., Tsujikawa, K., Matsuda, T. and Baba, A. (2005). Endothelin increases expression of exon III- and exon IV-containing brain-derived neurotrophic factor transcripts in cultured astrocytes and rat brain. J Neurosci Res 80(6): 809-816.
  25. Nagano, T., Osakada, M., Ago, Y., Koyama, Y., Baba, A., Maeda, S., Takemura, M. and Matsuda, T. (2005). SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger, attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia. Br J Pharmacol 144(5): 669-679.
Protocols by Yutaka Koyama
  1. ELISA Detection of Endogenous Serum Albumin in the Mouse Brain: A Measure of Extravasation Following Brain Injury