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Akira Oikawa


Ph.D. in Agriculture, Department of Applied Life Sciences, Kyoto University, 2003

Current position

Associate Professor in Metabolic Biochemistry, Department of Agriculture, Yamagata University

Publications (since 2005)

  1. Zargar, S. M., Kurata, R., Inaba, S., Oikawa, A., Fukui, R., Ogata, Y., Agrawal, G. K., Rakwal, R. and Fukao, Y. (2015). Quantitative proteomics of Arabidopsis shoot microsomal proteins reveals a cross-talk between excess zinc and iron deficiency. Proteomics 15(7): 1196-1201.
  2. Kusuda, H., Koga, W., Kusano, M., Oikawa, A., Saito, K., Hirai, M. Y. and Yoshida, K. T. (2015). Ectopic expression of myo-inositol 3-phosphate synthase induces a wide range of metabolic changes and confers salt tolerance in rice. Plant Sci 232: 49-56.
  3. Osanai, T., Oikawa, A., Iijima, H., Kuwahara, A., Asayama, M., Tanaka, K., Ikeuchi, M., Saito, K. and Hirai, M. Y. (2014). Metabolomic analysis reveals rewiring of Synechocystis sp. PCC 6803 primary metabolism by ntcA overexpression. Environ Microbiol 16(10): 3304-3317.
  4. Tawaraya, K., Horie, R., Saito, S., Wagatsuma, T., Saito, K. and Oikawa, A. (2014). Metabolite profiling of root exudates of common bean under phosphorus deficiency. Metabolites 4(3): 599-611.
  5. Satou, M., Enoki, H., Oikawa, A., Ohta, D., Saito, K., Hachiya, T., Sakakibara, H., Kusano, M., Fukushima, A., Saito, K., Kobayashi, M., Nagata, N., Myouga, F., Shinozaki, K. and Motohashi, R. (2014). Integrated analysis of transcriptome and metabolome of Arabidopsis albino or pale green mutants with disrupted nuclear-encoded chloroplast proteins. Plant Mol Biol 85(4-5): 411-428.
  6. Osanai, T., Oikawa, A., Numata, K., Kuwahara, A., Iijima, H., Doi, Y., Saito, K. and Hirai, M. Y. (2014). Pathway-level acceleration of glycogen catabolism by a response regulator in the cyanobacterium Synechocystis species PCC 6803. Plant Physiol 164(4): 1831-1841.
  7. Osanai, T., Numata, K., Oikawa, A., Kuwahara, A., Iijima, H., Doi, Y., Tanaka, K., Saito, K. and Hirai, M. Y. (2013). Increased bioplastic production with an RNA polymerase sigma factor SigE during nitrogen starvation in Synechocystis sp. PCC 6803. DNA Res 20(6): 525-535.
  8. Osanai, T., Oikawa, A., Shirai, T., Kuwahara, A., Iijima, H., Tanaka, K., Ikeuchi, M., Kondo, A., Saito, K. and Hirai, M. Y. (2014). Capillary electrophoresis-mass spectrometry reveals the distribution of carbon metabolites during nitrogen starvation in Synechocystis sp. PCC 6803. Environ Microbiol 16(2): 512-524.
  9. Tawaraya, K., Horie, R., Saito, A., Shinano, T., Wagatsuma, T., Saito, K. and Oikawa, A. (2013). Metabolite profiling of shoot extracts, root extracts, and root exudates of rice plant under phosphorus deficiency. J Plant Nutr 36(7): 1138-1159.
  10. Kim, J., Choi, J. N., John, K. M., Kusano, M., Oikawa, A., Saito, K. and Lee, C. H. (2012). GC-TOF-MS- and CE-TOF-MS-based metabolic profiling of cheonggukjang (fast-fermented bean paste) during fermentation and its correlation with metabolic pathways. J Agric Food Chem 60(38): 9746-9753.
  11. Ogawa, Y., Sakurai, N., Oikawa, A., Kai, K., Morishita, Y., Mori, K., Moriya, K., Fujii, F., Aoki, K., Suzuki, H., Ohta, D., Saito, K. and Shibata, D. (2012). High-throughput cryopreservation of plant cell cultures for functional genomics. Plant Cell Physiol 53(5): 943-952.
  12. Matsuda, F., Okazaki, Y., Oikawa, A., Kusano, M., Nakabayashi, R., Kikuchi, J., Yonemaru, J., Ebana, K., Yano, M. and Saito, K. (2012). Dissection of genotype-phenotype associations in rice grains using metabolome quantitative trait loci analysis. Plant J 70(4): 624-636.
  13. Liu, C., Kurakane, S., Takita, J., Itano, R., Soga, T., Oikawa, A. and Igarashi, K. (2012). Antihypertensive effects of unripe persimmon (Diospyros kaki L. cv. Hiratanenashi) fruit and its component in spontaneously hypertensive rats. Food Sci Technol Res 18(3): 391-398.
  14. Bunsupa, S., Katayama, K., Ikeura, E., Oikawa, A., Toyooka, K., Saito, K. and Yamazaki, M. (2012). Lysine decarboxylase catalyzes the first step of quinolizidine alkaloid biosynthesis and coevolved with alkaloid production in leguminosae. Plant Cell 24(3): 1202-1216.
  15. Redestig, H., Kusano, M., Ebana, K., Kobayashi, M., Oikawa, A., Okazaki, Y., Matsuda, F., Arita, M., Fujita, N. and Saito, K. (2011). Exploring molecular backgrounds of quality traits in rice by predictive models based on high-coverage metabolomics. BMC Syst Biol 5: 176.
  16. Oikawa, A., Otsuka, T., Jikumaru, Y., Yamaguchi, S., Matsuda, F., Nakabayashi, R., Takashina, T., Isuzugawa, K., Saito, K. and Shiratake, K. (2011). Effects of freeze-drying of samples on metabolite levels in metabolome analyses. J Sep Sci 34(24): 3561-3567.
  17. Oikawa, A., Matsuda, F., Kikuyama, M., Mimura, T. and Saito, K. (2011). Metabolomics of a single vacuole reveals metabolic dynamism in an alga Chara australis. Plant Physiol 157(2): 544-551.
  18. Osanai, T., Oikawa, A., Azuma, M., Tanaka, K., Saito, K., Hirai, M. Y. and Ikeuchi, M. (2011). Genetic engineering of group 2 sigma factor SigE widely activates expressions of sugar catabolic genes in Synechocystis species PCC 6803. J Biol Chem 286(35): 30962-30971.
  19. Skirycz, A., Claeys, H., De Bodt, S., Oikawa, A., Shinoda, S., Andriankaja, M., Maleux, K., Eloy, N. B., Coppens, F., Yoo, S. D., Saito, K. and Inze, D. (2011). Pause-and-stop: the effects of osmotic stress on cell proliferation during early leaf development in Arabidopsis and a role for ethylene signaling in cell cycle arrest. Plant Cell 23(5): 1876-1888.
  20. Toyokura, K., Watanabe, K., Oiwaka, A., Kusano, M., Tameshige, T., Tatematsu, K., Matsumoto, N., Tsugeki, R., Saito, K. and Okada, K. (2011). Succinic semialdehyde dehydrogenase is involved in the robust patterning of Arabidopsis leaves along the adaxial–abaxial axis. Plant and Cell Physiology 52(8): 1340-1353.
  21. Saika, H., Oikawa, A., Matsuda, F., Onodera, H., Saito, K. and Toki, S. (2011). Application of gene targeting to designed mutation breeding of high-tryptophan rice. Plant Physiol 156(3): 1269-1277.
  22. Oikawa, A., Fujita, N., Horie, R., Saito, K. and Tawaraya, K. (2011). Solid-phase extraction for metabolomic analysis of high-salinity samples by capillary electrophoresis-mass spectrometry. J Sep Sci 34(9): 1063-1068.
  23. Kusano, M., Redestig, H., Hirai, T., Oikawa, A., Matsuda, F., Fukushima, A., Arita, M., Watanabe, S., Yano, M., Hiwasa-Tanase, K., Ezura, H. and Saito, K. (2011). Covering chemical diversity of genetically-modified tomatoes using metabolomics for objective substantial equivalence assessment. PLoS One 6(2): e16989.
  24. Ide, Y., Kusano, M., Oikawa, A., Fukushima, A., Tomatsu, H., Saito, K., Hirai, M. Y. and Fujiwara, T. (2011). Effects of molybdenum deficiency and defects in molybdate transporter MOT1 on transcript accumulation and nitrogen/sulphur metabolism in Arabidopsis thaliana. J Exp Bot 62(4): 1483-1497.
  25. Ohkama-Ohtsu, N., Sasaki-Sekimoto, Y., Oikawa, A., Jikumaru, Y., Shinoda, S., Inoue, E., Kamide, Y., Yokoyama, T., Hirai, M. Y., Shirasu, K., Kamiya, Y., Oliver, D. J. and Saito, K. (2011). 12-oxo-phytodienoic acid-glutathione conjugate is transported into the vacuole in Arabidopsis. Plant Cell Physiol 52(1): 205-209.
  26. Baek, D., Pathange, P., Chung, J. S., Jiang, J., Gao, L., Oikawa, A., Hirai, M. Y., Saito, K., Pare, P. W. and Shi, H. (2010). A stress-inducible sulphotransferase sulphonates salicylic acid and confers pathogen resistance in Arabidopsis. Plant Cell Environ 33(8): 1383-1392.
  27. Matsuda, F., Shinbo, Y., Oikawa, A., Hirai, M. Y., Fiehn, O., Kanaya, S. and Saito, K. (2009). Assessment of metabolome annotation quality: a method for evaluating the false discovery rate of elemental composition searches. PLoS One 4(10): e7490.
  28. Ohkama-Ohtsu, N., Oikawa, A., Zhao, P., Xiang, C., Saito, K. and Oliver, D. J. (2008). A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis. Plant Physiol 148(3): 1603-1613.
  29. Watanabe, M., Kusano, M., Oikawa, A., Fukushima, A., Noji, M. and Saito, K. (2008). Physiological roles of the beta-substituted alanine synthase gene family in Arabidopsis. Plant Physiol 146(1): 310-320.
  30. Nakamura, Y., Kimura, A., Saga, H., Oikawa, A., Shinbo, Y., Kai, K., Sakurai, N., Suzuki, H., Kitayama, M., Shibata, D., Kanaya, S. and Ohta, D. (2007). Differential metabolomics unraveling light/dark regulation of metabolic activities in Arabidopsis cell culture. Planta 227(1): 57-66.
  31. Oikawa, A., Nakamura, Y., Ogura, T., Kimura, A., Suzuki, H., Sakurai, N., Shinbo, Y., Shibata, D., Kanaya, S. and Ohta, D. (2006). Clarification of pathway-specific inhibition by Fourier transform ion cyclotron resonance/mass spectrometry-based metabolic phenotyping studies. Plant Physiol 142(2): 398-413.
  32. Morikawa, T., Mizutani, M., Aoki, N., Watanabe, B., Saga, H., Saito, S., Oikawa, A., Suzuki, H., Sakurai, N., Shibata, D., Wadano, A., Sakata, K. and Ohta, D. (2006). Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato. Plant Cell 18(4): 1008-1022.
Protocols by Akira Oikawa
  1. Arabidopsis Metabolome Analysis Using Infusion ESI FT-ICR/MS