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Robert Zeiser

Education

Pr.D., Division of Haematology, Oncology and Stem Cell Transplantation Department of Internal Medicine I Medical Center , University of Freiburg Hugstetterstr.

Current position

W3 Professor, Heisenberg Group Leader, Division of Haematology, Oncology and Stem Cell Transplantation, Department of Internal Medicine II, Medical Center, University of Freiburg

Publications

  1. Schwab, L.*, Goroncy, L.*, Palaniyandi, S., Gautam, S., Triantafyllopoulou, A., Mocsai, A., Reichardt, W., Karlsson, F. J., Radhakrishnan, S. V., Hanke, K., Schmitt-Graeff, A., Freudenberg, M., von Loewenich, F. D., Wolf, P., Leonhardt, F., Baxan, N., Pfeifer, D., Schmah, O., Schönle, A., Martin, S. F., Mertelsmann, R., Duyster, J., Finke, J., Prinz, M., Henneke, P., Häcker, H., Hildebrandt, G. C.*, Häcker, G.* and Zeiser, R.* (2014). Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage. Nat Med 20(6): 648-654.
  2. Spoerl, S., Mathew, N. R., Bscheider, M., Schmitt-Graeff, A., Chen, S., Mueller, T., Verbeek, M., Fischer, J., Otten, V., Schmickl, M., Maas-Bauer, K., Finke, J., Peschel, C., Duyster, J., Poeck, H., Zeiser, R.* and von Bubnoff, N.* (2014). Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease. Blood 123(24): 3832-3842.
  3. Jankovic, D., Ganesan, J., Bscheider, M., Stickel, N., Weber, F. C., Guarda, G., Follo, M., Pfeifer, D., Tardivel, A., Ludigs, K., Bouazzaoui, A., Kerl, K., Fischer, J. C., Haas, T., Schmitt-Gräff, A., Manoharan, A., Muller, L., Finke, J., Martin, S. F., Gorka, O., Peschel, C., Ruland, J., Idzko, M., Duyster, J., Holler, E., French, L. E., Poeck, H.*, Contassot, E.* and Zeiser, R.* (2013). The Nlrp3 inflammasome regulates acute graft-versus-host disease. J Exp Med 210(10): 1899-1910.
  4. Leonhardt, F., Grundmann, S., Behe, M., Bluhm, F., Dumont, R. A., Braun, F., Fani, M., Riesner, K., Prinz, G., Hechinger, A. K., Gerlach, U. V., Dierbach, H., Penack, O., Schmitt-Gräff, A., Finke, J., Weber, W. A. and Zeiser, R. (2013). Inflammatory neovascularization during graft-versus-host disease is regulated by alphav integrin and miR-100. Blood 121(17): 3307-3318.
  5. Hechinger, A. K., Maas, K., Dürr, C., Leonhardt, F., Prinz, G., Marks, R., Gerlach, U., Hofmann, M., Fisch, P., Finke, J., Pircher, H. and Zeiser, R. (2013). Inhibition of protein geranylgeranylation and farnesylation protects against graft-versus-host disease via effects on CD4 effector T cells. Haematologica 98(1): 31-40.
  6. Leonhardt, F., Zirlik, K., Buchner, M., Prinz, G., Hechinger, A. K., Gerlach, U. V., Fisch, P., Schmitt-Gräff, A., Reichardt, W. and Zeiser, R. (2012). Spleen tyrosine kinase (Syk) is a potent target for GvHD prevention at different cellular levels. Leukemia 26(7): 1617-1629.
  7. Tsukamoto, H., Chernogorova, P., Ayata, K., Gerlach, U. V., Rughani, A., Ritchey, J. W., Ganesan, J., Follo, M., Zeiser, R.*, Thompson, L. F.* and Idzko, M.* (2012). Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease. Blood 119(19): 4554-4564.
  8.  Dürr, C., Follo, M., Idzko, M., Reichardt, W. and Zeiser, R. (2012). Graft-versus-host disease reduces regulatory T-cell migration into the tumour tissue. Immunology 137(1): 80-88.
  9. Dürr, C., Pfeifer, D., Claus, R., Schmitt-Graeff, A., Gerlach, U. V., Graeser, R., Krüger, S., Gerbitz, A., Negrin, R. S., Finke, J. and Zeiser, R. (2010). CXCL12 mediates immunosuppression in the lymphoma microenvironment after allogeneic transplantation of hematopoietic cells. Cancer Res 70(24): 10170-10181.
  10. Wilhelm, K., Ganesan, J., Müller, T., Dürr, C., Grimm, M., Beilhack, A., Krempl, C.D., Sorichter, S., Gerlach, U.V., Jüttner, E., Zerweck, A., Gärtner, F., Pellegatti, P., Di Virgilio, F., Ferrari, D., Kambham, N., Fisch, P., Finke, J., Idzko, M.* and Zeiser, R.* (2010). Graft-versus-host disease is enhanced by extracellular adenosine triphosphate activating P2X7R. Nat Med 12: 1434-1438.
Protocols by Robert Zeiser
  1. Gram Stain for Intestinal Bacteria
  2. Neutrophil Isolation from the Intestines