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Malcolm J. McConville

Education

Ph.D., University of Melbourne, Australia

Current position

Professor, Department of Biochemistry and Molecular Biology, University of Melbourne
Acting Director of the University of Melbourne Bio21 Institute of Molecular Science and a National Health and Medical Research Council Principal Research Fellow
Co-head of a national metabolomics analytical facility funded by the Australian Federal Government initiative

Publications

  1. Kloehn, J., Saunders, E. C., O'Callaghan, S., Dagley, M. J. and McConville, M. J. (2015). Characterization of metabolically quiescent leishmania parasites in murine lesions using heavy water labeling. PLoS Pathog 11(2): e1004683.
  2. Saunders, E. C., de Souza, D. P., Chambers, J. M., Ng, M., Pyke, J. and McConville, M. J. (2015). Use of (13)C stable isotope labelling for pathway and metabolic flux analysis in Leishmania parasites. Methods Mol Biol 1201: 281-296.
  3. Saunders, E. C., Ng, W. W., Kloehn, J., Chambers, J. M., Ng, M. and McConville, M. J. (2014). Induction of a stringent metabolic response in intracellular stages of Leishmania mexicana leads to increased dependence on mitochondrial metabolism. PLoS Pathog 10(1): e1003888. (IF=8.1)
  4. Macrae, J. I., Lopaticki, S., Maier, A. G., Rupasinghe, T., Nahid, A., Cowman, A. F. and McConville, M. J. (2014). Plasmodium falciparum is dependent on de novo myo-inositol biosynthesis for assembly of GPI glycolipids and infectivity. Mol Microbiol 91(4): 762-776.
  5. Tan, K. H., Seers, C. A., Dashper, S. G., Mitchell, H. L., Pyke, J. S., Meuric, V., Slakeski, N., Cleal, S. M., Chambers, J. L., McConville, M. J. and Reynolds, E. C. (2014). Porphyromonas gingivalis and Treponema denticola exhibit metabolic symbioses. PLoS Pathog 10(3): e1003955. (IF=8.1)
  6. Oppenheim, R. D., Creek, D. J., Macrae, J. I., Modrzynska, K. K., Pino, P., Limenitakis, J., Polonais, V., Seeber, F., Barrett, M. P., Billker, O., McConville, M. J. and Soldati-Favre, D. (2014). BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei. PLoS Pathog 10(7): e1004263. (IF=8.1)
  7. Sheedy, J. R., Gooley, P. R., Nahid, A., Tull, D. L., McConville, M. J., Kukuljan, S., Nowson, C. A., Daly, R. M. and Ebeling, P. R. (2014). (1)H-NMR analysis of the human urinary metabolome in response to an 18-month multi-component exercise program and calcium-vitamin-D3 supplementation in older men. Appl Physiol Nutr Metab 39(11): 1294-1304.
  8. Gregory, M., Yin, M. X., McConville, M. J., Williams, E., Bullock, A. N., Conway, S. J., Burgess, A. W., Catimel, B. and Holmes, A. B.  (2014). Synthesis of highly water soluble adamantyl phosphoinositide derivatives. Aust J Chem.
  9. Sansom, F. M., Ralton, J. E., Sernee, M. F., Cohen, A. M., Hooker, D. J., Hartland, E. L., Naderer, T. and McConville, M. J. (2014). Golgi-located NTPDase1 of Leishmania major is required for lipophosphoglycan elongation and normal lesion development whereas secreted NTPDase2 is dispensable for virulence. PLoS Negl Trop Dis 8(12): e3402.
  10. Kowalski, G. M., Kloehn, J., Burch, M. L., Selathurai, A., Hamley, S., Bayol, S. A., Lamon, S., Watt, M. J., Lee-Young, R. S., McConville, M. J. and Bruce, C. R. (2015). Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet. Biochim Biophys Acta 1851(2): 210-219.
  11. Yamaryo-Botte, Y., Rainczuk, A. K., Lea-Smith, D. J., Brammananth, R., van der Peet, P. L., Meikle, P., Ralton, J. E., Rupasinghe, T. W., Williams, S. J., Coppel, R. L., Crellin, P. K. and McConville, M. J. (2014). Acetylation of Trehalose Mycolates Is Required for Efficient MmpL-Mediated Membrane Transport in Corynebacterineae. ACS Chem Biol. (Epub ahead of print)
  12. Coombe, D. R., Davis, C., Fincher, G., McConville, M. J., Packer, N., Stubbs, K. A., Williams, S. J. and Dell, A. (2014). Letter to the glycoforum transforming glycoscience: an Australian perspective. Glycobiology 24(1): 1-3.
  13. McConville, M. J. (2014). Using fat to turbo-charge intracellular parasite growth. Cell Host Microbe 16(6): 705-707.
  14. Danne, J. C., Gornik, S. G., Macrae, J. I., McConville, M. J. and Waller, R. F. (2013). Alveolate mitochondrial metabolic evolution: dinoflagellates force reassessment of the role of parasitism as a driver of change in apicomplexans. Mol Biol Evol 30(1): 123-139.
  15. Sansom, F. M., Tang, L., Ralton, J. E., Saunders, E. C., Naderer, T. and McConville, M. J. (2013). Leishmania major methionine sulfoxide reductase A is required for resistance to oxidative stress and efficient replication in macrophages. PLoS One 8(2): e56064.
  16. Cao, B., Chen, X., Yamaryo-Botte, Y., Richardson, M. B., Martin, K. L., Khairallah, G. N., Rupasinghe, T. W., O'Flaherty, R. M., O'Hair, R. A., Ralton, J. E., Crellin, P. K., Coppel, R. L., McConville, M. J.* and Williams, S. J.* (2013). Synthesis, structural elucidation, and biochemical analysis of immunoactive glucuronosyl diacylglycerides of mycobacteria and corynebacteria. J Org Chem 78(6): 2175-2190. (*Corresponding authors)
  17. Botte, C. Y., Yamaryo-Botte, Y., Rupasinghe, T. W., Mullin, K. A., MacRae, J. I., Spurck, T. P., Kalanon, M., Shears, M. J., Coppel, R. L., Crellin, P. K., Marechal, E., McConville, M. J.* and McFadden, G. I.* (2013). Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites. Proc Natl Acad Sci U S A 110(18): 7506-7511. (*Corresponding authors)
  18. MacRae, J. I., Dixon, M. W., Dearnley, M. K., Chua, H. H., Chambers, J. M., Kenny, S., Bottova, I., Tilley, L. and McConville, M. J. (2013). Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum. BMC Biol 11: 67.
  19. Heng, J., Saunders, E. C., Gooley, P. R., McConville, M. J., Naderer, T. and Tull, D. (2013). Membrane targeting of the small myristoylated protein 2 (SMP-2) in Leishmania major. Mol Biochem Parasitol 190(1): 1-5.
  20. Tull, D., Heng, J., Gooley, P. R., Naderer, T. and McConville, M. J. (2012). Acylation-dependent and-independent membrane targeting and distinct functions of small myristoylated proteins (SMPs) in Leishmania major. Int J Parasitol 42(3): 239-247.
  21. Temmerman, L., Bowne, J., De Livera, A. M., Sheedy, J. R., Callaghan, D. L., Schoofs, L., Tull, D. L., McConville, M. J., Olayfair, J., O’Brian, P. E., Roessner, U. and Wentworth, J. M. (2012). The urine metabolome in experimental hyperglycermia. J Diabetes Metabolism. (Cited 2)
  22. van der Peet, P., Ralton, J. E., McConville, M. J. and Williams, S. J. (2012). Discovery of inhibitors of Leishmania beta-1,2-mannosyltransferases using a click-chemistry-derived guanosine monophosphate library. PLoS One 7(2): e32642.
  23. O'Callaghan, S., De Souza, D. P., Isaac, A., Wang, Q., Hodkinson, L., Olshansky, M., Erwin, T., Appelbe, B., Tull, D. L., Roessner, U., Bacic, A., McConville, M. J. and Likic, V. A. (2012). PyMS: a Python toolkit for processing of gas chromatography-mass spectrometry (GC-MS) data. Application and comparative study of selected tools. BMC Bioinformatics 13: 115. (Cited 2)
  24. Saunders, E. C., MacRae, J. I., Naderer, T., Ng, M., McConville, M. J. and Likic, V. A. (2012). LeishCyc: a guide to building a metabolic pathway database and visualization of metabolomic data. Methods Mol Biol 881: 505-529.
  25. MacRae, J. I., Sheiner, L., Nahid, A., Tonkin, C., Striepen, B. and McConville, M. J. (2012). Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii. Cell Host Microbe 12(5): 682-692.
  26. Kjer-Nielsen, L., Patel, O., Corbett, A. J., Le Nours, J., Meehan, B., Liu, L., Bhati, M., Chen, Z., Kostenko, L., Reantragoon, R., Williamson, N. A., Purcell, A. W., Dudek, N. L., McConville, M. J., O'Hair, R. A., Khairallah, G. N., Godfrey, D. I., Fairlie, D. P., Rossjohn, J. and McCluskey, J. (2012). MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 491(7426): 717-723.
  27. Rainczuk, A. K., Yamaryo-Botte, Y., Brammananth, R., Stinear, T. P., Seemann, T., Coppel, R. L., McConville, M. J. and Crellin, P. K. (2012). The lipoprotein LpqW is essential for the mannosylation of periplasmic glycolipids in Corynebacteria. J Biol Chem 287(51): 42726-42738. (*Equal senior authors)
  28. De Livera, A. M., Dias, D. A., De Souza, D., Rupasinghe, T., Pyke, J., Tull, D., Roessner, U., McConville, M. and Speed, T. P. (2012). Normalizing and integrating metabolomics data. Anal Chem 84(24): 10768-10776.
  29. Dagley, M. J., Gentle, I. E., Beilharz, T. H., Pettolino, F. A., Djordjevic, J. T., Lo, T. L., Uwamahoro, N., Rupasinghe, T., Tull, D. L., McConville, M., Beaurepaire, C., Nantel, A., Lithgow, T., Mitchell, A. P. and Traven, A. (2011). Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post-transcriptional regulator Ccr4-Pop2. Mol Microbiol 79(4): 968-989. (IF=5.5 , cited 11)
  30. Naderer, T., Dandash, O. and McConville, M. J. (2011). Calcineurin is required for Leishmania major stress response pathways and for virulence in the mammalian host. Mol Microbiol 80(2): 471-480. (IF=5.5, cited 6)
  31. Vince, J. E., Tull, D., Landfear, S. and McConville, M. J. (2011). Lysosomal degradation of Leishmania hexose and inositol transporters is regulated in a stage-, nutrient- and ubiquitin-dependent manner. Int J Parasitol 41(7): 791-800. (IF=3.4 , cited 2)
  32. Saunders, E. C., Ng, W. W., Chambers, J. M., Ng, M., Naderer, T., Kromer, J. O., Likic, V. A. and McConville, M. J. (2011). Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth. J Biol Chem 286(31): 27706-27717. (IF=5.5, cited 8)
  33. Botte, C. Y., Yamaryo-Botte, Y., Janouskovec, J., Rupasinghe, T., Keeling, P. J., Crellin, P., Coppel, R. L., Marechal, E., McConville, M. J. and McFadden, G. I. (2011). Identification of plant-like galactolipids in Chromera velia, a photosynthetic relative of malaria parasites. J Biol Chem 286(34): 29893-29903. (IF=5.5, cited 7)
  34. Boughton, B. A., Callahan, D. L., Silva, C., Bowne, J., Nahid, A., Rupasinghe, T., Tull, D. L., McConville, M. J., Bacic, A. and Roessner, U. (2011). Comprehensive profiling and quantitation of amine group containing metabolites. Anal Chem 83(19): 7523-7530. (IF=5.5, cited 4)
  35. Ramakrishnan, S., Docampo, M. D., Macrae, J. I., Pujol, F. M., Brooks, C. F., van Dooren, G. G., Hiltunen, J. K., Kastaniotis, A. J., McConville, M. J. and Striepen, B. (2012). Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii. J Biol Chem 287(7): 4957-4971. (*Equal senior author) (IF=5.5, cited 1)
  36. Tull, D., Naderer, T., Spurck, T., Mertens, H. D., Heng, J., McFadden, G. I., Gooley, P. R. and McConville, M. J. (2010). Membrane protein SMP-1 is required for normal flagellum function in Leishmania. J Cell Sci 123(Pt 4): 544-554. (IF=5.3, cited 7).
  37. Morita, Y. S., Yamaryo-Botte, Y., Miyanagi, K., Callaghan, J. M., Patterson, J. H., Crellin, P. K., Coppel, R. L., Billman-Jacobe, H., Kinoshita, T. and McConville, M. J. (2010). Stress-induced synthesis of phosphatidylinositol 3-phosphate in mycobacteria. J Biol Chem 285(22): 16643-16650. (IF=5.5, cited 6)
  38. Low, W. Y., Feil, S. C., Ng, H. L., Gorman, M. A., Morton, C. J., Pyke, J., McConville, M. J., Bieri, M., Mok, Y. F., Robin, C., Gooley, P. R., Parker, M. W. and Batterham, P. (2010). Recognition and detoxification of the insecticide DDT by Drosophila melanogaster glutathione S-transferase D1. J Mol Biol 399(3): 358-366. (IF=4, cited 10)
  39. Sheedy, J. R., Ebeling, P. R., Gooley, P. R. and McConville, M. J. (2010). A sample preparation protocol for 1H nuclear magnetic resonance studies of water-soluble metabolites in blood and urine. Anal Biochem 398(2): 263-265. (IF=2.3, cited 1)
  40. Naderer, T., Heng, J. and McConville, M. J. (2010). Evidence that intracellular stages of Leishmania major utilize amino sugars as a major carbon source. PLoS Pathog 6(12): e1001245. (IF=9.1, cited 6)
Protocols by Malcolm J. McConville
  1. A Gas Chromatography-Mass Spectrometry-Based Two Stage Assay for Measurement of in vitro myo-Inositol 3-phosphate Synthase (INO1) Activity