Welcome guest, Sign in


Shai Berlin


Ph.D. in Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Israel, 2011

Current position

I am currently an associate professor at the Rappaport Faculty of Medicine- Technion, Israel. My research focuses on the development of sensors and optogenetic tools for the study of synaptic plasticity.


  1. Berlin, S., Szobota, S., Reiner, A., Carroll, E. C., Kienzler, M. A., Guyon, A., Xiao, T., Tauner, D. and Isacoff, E. Y. (2016). A family of photoswitchable NMDA receptors. Elife 5. (Epub ahead of print) 
  2. Berlin, S., Carroll, E. C., Newman, Z. L., Okada, H. O., Quinn, C. M., Kallman, B., Rockwell, N. C., Martin, S. S., Lagarias, J. C. and Isacoff, E. Y. (2015). Photoactivatable genetically encoded calcium indicators for targeted neuronal imaging. Nat Methods. (Epub ahead of print)
  3. Yakubovich, D.*, Berlin, S.*, Kahanovitch, U.*, Rubinstein, M., Farhy-Tselnicker, I., Styr, B., Keren-Raifman, T., Dessauer, C. W. and Dascal, N. (2015). A quantitative model of the GIRK1/2 channel reveals that its basal and evoked activities are controlled by unequal stoichiometry of galpha and gbetagamma. PLoS Comput Biol 11(11): e1004598. (*Co-1st authors) 
  4. Berlin, S. (2015). Paper-trail index: Can a metric that captures a paper's history of submission and rejection give insight into its value and encourage good authorship practices? EMBO Rep 16(8): 889-893.   
  5. Carroll, E. C., Berlin, S., Levitz, J., Kienzler, M. A., Yuan, Z., Madsen, D., Larsen, D. S. and Isacoff, E. Y. (2015). Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics. Proc Natl Acad Sci U S A 112(7): E776-785.
  6. Friedmann, D., Hoagland, A., Berlin, S. and Isacoff, E. Y. (2015). A spinal opsin controls early neural activity and drives a behavioral light response. Curr Biol 25(1): 69-74.   
  7. Kahanovitch, U., Tsemakhovich, V., Berlin, S., Rubinstein, M., Styr, B., Castel, R., Peleg, S., Tabak, G., Dessauer, C. W., Ivanina, T. and Dascal, N. (2014). Recruitment of Gbetagamma controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1. J Physiol 592(Pt 24): 5373-5390.
  8. Greitzer-Antes, D., Barak-Broner, N., Berlin, S., Oron, Y., Chikvashvili, D. and Lotan, I. (2013). Tracking Ca2+-dependent and Ca2+-independent conformational transitions in syntaxin 1A during exocytosis in neuroendocrine cells. J Cell Sci 126(Pt 13): 2914-2923.
  9. Berlin, S., Tsemakhovich, V. A., Castel, R., Ivanina, T., Dessauer, C. W., Keren-Raifman, T. and Dascal, N. (2011). Two distinct aspects of coupling between Galpha(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Galpha(i3) protein subunits. J Biol Chem 286(38): 33223-33235.
  10.  Berlin, S. (2010). It takes two to tango. EMBO Rep 11(3): 150-151; author reply 151-152. 
  11. Berlin, S. (2009). Do bigger and "better" labs have easier access to high impact factor journals? Science signaling. E-letter.
  12. Berlin, S., Keren-Raifman, T., Castel, R., Rubinstein, M., Dessauer, C. W., Ivanina, T. and Dascal, N. (2010). G alpha(i) and G betagamma jointly regulate the conformations of a G betagamma effector, the neuronal G protein-activated K+ channel (GIRK). J Biol Chem 285(9): 6179-6185.
  13. Lvov, A., Greitzer, D., Berlin, S., Chikvashvili, D., Tsuk, S., Lotan, I. and Michaelevski, I. (2009). Rearrangements in the relative orientation of cytoplasmic domains induced by a membrane-anchored protein mediate modulations in Kv channel gating. J Biol Chem 284(41): 28276-28291.
  14. Rubinstein, M., Peleg, S., Berlin, S., Brass, D., Keren-Raifman, T., Dessauer, C. W., Ivanina, T. and Dascal, N. (2009). Divergent regulation of GIRK1 and GIRK2 subunits of the neuronal G protein gated K+ channel by GalphaiGDP and Gbetagamma. J Physiol 587(Pt 14): 3473-3491.
  15. Rubinstein, M., Peleg, S., Berlin, S., Brass, D. and Dascal, N. (2007). Galphai3 primes the G protein-activated K+ channels for activation by coexpressed Gbetagamma in intact Xenopus oocytes. J Physiol 581(Pt 1): 17-32.
  16.  Eliyahu, U., Berlin, S., Hadad, E., Heled, Y. and Moran, D. S. (2007). Psychostimulants and military operations. Mil Med 172(4): 383-387.
  17. Berlin, S., Shalit, L., Yarom, Y. and Moran, D. S. (2007). Metabolic rate prediction by massless actigraphy for outdoor activities. Mil Med 172(8): 882-887.
  18. Berlin, S., Hadad, E., Heled, Y. and Moran, S. D. (2004). The efficacy of nutritional supplements upon physical exercise. Journal of Israeli Military Medicine 1(2): 72-80.