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Qin Yan


Ph.D. in Cell Biology, Life Science College, Hunan Normal University, 2004

Current position

Senior Research Associate in Infectious Diseases, Department of Medicine, Duke University, Durham, North Carolina, USA

Publications (since 2004)

  1. Sharma-Kuinkel, B. K., Wu, Y., Tabor, D. E., Mok, H., Sellman, B. R., Jenkins, A., Yu, L., Jafri, H. S., Rude, T. H., Ruffin, F., Schell, W. A., Park, L. P., Yan, Q., Thaden, J. T., Messina, J. A., Fowler, V. G., Jr. and Esser, M. T. (2015). Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia. J Clin Microbiol 53(1): 227-236.
  2. Yan, Q., Sharma-Kuinkel, B. K., Deshmukh, H., Tsalik, E. L., Cyr, D. D., Lucas, J., Woods, C. W., Scott, W. K., Sempowski, G. D., Thaden, J., Rude, T. H., Ahn, S. H. and Fowler, V. G., Jr. (2014). Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. PLoS Pathog 10(6): e1004149.
  3. Sharma-Kuinkel, B. K., Zhang, Y., Yan, Q., Ahn, S. H. and Fowler, V. G., Jr. (2013). Host gene expression profiling and in vivo cytokine studies to characterize the role of linezolid and vancomycin in methicillin-resistant Staphylococcus aureus (MRSA) murine sepsis model. PLoS One 8(4): e60463.
  4. Yan, Q., Carmody, R. J., Qu, Z., Ruan, Q., Jager, J., Mullican, S. E., Lazar, M. A. and Chen, Y. H. (2012). Nuclear factor-kappaB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome. Proc Natl Acad Sci U S A 109(35): 14140-14145.
  5. Liu, W. B., Yan, Q., Liu, F. Y., Tang, X. C., Chen, H. G., Liu, J., Nie, L., Zhang, X. W., Ji, W. K., Hu, X. H., Hu, W. F., Woodward, Z., Wu, K. L., Wu, M. X., Liu, X. L., Luo, L. X., Yu, M. B., Liu, Y. Z., Liu, S. J. and Li, D. W. (2012). Protein serine/threonine phosphotase-1 is essential in governing normal development of vertebrate eye. Curr Mol Med 12(10): 1361-1371.
  6. Hu, W. F., Gong, L., Cao, Z., Ma, H., Ji, W., Deng, M., Liu, M., Hu, X. H., Chen, P., Yan, Q., Chen, H. G., Liu, J., Sun, S., Zhang, L., Liu, J. P., Wawrousek, E. and Li, D. W. (2012). alphaA- and alphaB-crystallins interact with caspase-3 and Bax to guard mouse lens development. Curr Mol Med 12(2): 177-187.
  7. Zhang, L., Sun, S., Zhou, J., Liu, J., Lv, J. H., Yu, X. Q., Li, C., Gong, L., Yan, Q., Deng, M., Xiao, L., Ma, H., Liu, J. P., Peng, Y. L., Wang, D., Liao, G. P., Zou, L. J., Liu, W. B., Xiao, Y. M. and Li, D. W. (2011). Knockdown of Akt1 promotes Akt2 upregulation and resistance to oxidative-stress-induced apoptosis through control of multiple signaling pathways. Antioxid Redox Signal 15(1): 1-17.
  8. Zhang, L., Yan, Q., Liu, J. P., Zou, L. J., Liu, J., Sun, S., Deng, M., Gong, L., Ji, W. K. and Li, D. W. (2010). Apoptosis: its functions and control in the ocular lens. Curr Mol Med 10(9): 864-875.
  9. Yan, Q., Gong, L., Deng, M., Zhang, L., Sun, S., Liu, J., Ma, H., Yuan, D., Chen, P. C., Hu, X., Liu, J., Qin, J., Xiao, L., Huang, X. Q., Zhang, J. and Li, D. W. (2010). Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Proc Natl Acad Sci U S A 107(49): 21034-21039.
  10. Xiao, L., Gong, L. L., Yuan, D., Deng, M., Zeng, X. M., Chen, L. L., Zhang, L., Yan, Q., Liu, J. P., Hu, X. H., Sun, S. M., Liu, J., Ma, H. L., Zheng, C. B., Fu, H., Chen, P. C., Zhao, J. Q., Xie, S. S., Zou, L. J., Xiao, Y. M., Liu, W. B., Zhang, J., Liu, Y. and Li, D. W. (2010). Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation. Cell Death Differ 17(9): 1448-1462.
  11. Yan, Q., Mao, Y. W. and Li, D. W. (2009). Protein serine/threonine phosphatases in the nervous system. In: Windhorst, B. H. (ed). Encyclopedia of Neuroscience. Springer, 3325-3329.
  12. Qin, J., Chen, H. G., Yan, Q., Deng, M., Liu, J., Doerge, S., Ma, W., Dong, Z. and Li, D. W. (2008). Protein phosphatase-2A is a target of epigallocatechin-3-gallate and modulates p53-Bak apoptotic pathway. Cancer Res 68(11): 4150-4162.
  13. Yan, Q., Liu, W. B., Qin, J., Liu, J., Chen, H. G., Huang, X., Chen, L., Sun, S., Deng, M., Gong, L., Li, Y., Zhang, L., Liu, Y., Feng, H., Xiao, Y., Liu, Y. and Li, D. W. (2007). Protein phosphatase-1 modulates the function of Pax-6, a transcription factor controlling brain and eye development. J Biol Chem 282(19): 13954-13965.
  14. Yan, Q., Liu, J. P. and Li, D. W. (2006). Apoptosis in lens development and pathology. Differentiation 74(5): 195-211.
  15. Li, D. W., Liu, J. P., Schmid, P. C., Schlosser, R., Feng, H., Liu, W. B., Yan, Q., Gong, L., Sun, S. M., Deng, M. and Liu, Y. (2006). Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities. Oncogene 25(21): 3006-3022.
  16. Huang, X. Q., Wang, J., Liu, J. P., Feng, H., Liu, W. B., Yan, Q., Liu, Y., Sun, S. M., Deng, M., Gong, L., Liu, Y. and Li, D. W. (2005). hTERT extends proliferative lifespan and prevents oxidative stress-induced apoptosis in human lens epithelial cells. Invest Ophthalmol Vis Sci 46(7): 2503-2513.
  17. Wang, J., Feng, H., Huang, X. Q., Xiang, H., Mao, Y. W., Liu, J. P., Yan, Q., Liu, W. B., Liu, Y., Deng, M., Gong, L., Sun, S., Luo, C., Liu, S. J., Zhang, X. J., Liu, Y. and Li, D. W. (2005). Human telomerase reverse transcriptase immortalizes bovine lens epithelial cells and suppresses differentiation through regulation of the ERK signaling pathway. J Biol Chem 280(24): 22776-22787.
  18. Yan, Q. and Luo, C. (2004). Genetic and biochemical characteristics of mitochondrial superoxide dismutase in grass carp, Ctenopharyngodon idellus. Acta Zoologica Sinica (Current Zoology) 50: 289-39.
Protocols by Qin Yan
  1. Macrophage Phagocytosis Assay of Staphylococcus aureus by Flow Cytometry