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Christopher M. Waters


Ph.D., University of Minnesota, 2002

Current position

Associate Professor of Microbiology, Michigan State University

Publications (since 2010)

  1. Koestler, B. J., Seregin, S. S., Rastall, D. P., Aldhamen, Y. A., Godbehere, S., Amalfitano, A. and Waters, C. M. (2014). Stimulation of innate immunity by in vivo cyclic di-GMP synthesis using adenovirus. Clin Vaccine Immunol 21(11): 1550-1559.
  2. Wu, X., Zeng, Q., Koestler, B. J., Waters, C. M., Sundin, G. W., Hutchins, W. and Yang, C.-H. (2014). Deciphering the components that coordinately regulate virulence factors of the soft rot pathogen Dickeya dadantii. Mol Plant Microbe In 27(10): 1119-1131.
  3. Koestler, B. J. and Waters, C. M. (2014). Bile acids and bicarbonate inversely regulate intracellular cyclic di-GMP in Vibrio cholerae. Infect Immun 82(7): 3002-3014.
  4. Bobrov, A. G., Kirillina, O., Vadyvaloo, V., Koestler, B. J., Hinz, A. K., Mack, D., Waters, C. M. and Perry, R. D. (2014). The Yersinia pestis HmsCDE regulatory system is essential for blockage of the oriental rat flea (Xenopsylla cheopis), a classic plague vector. Environ Microbiol.
  5. Hunter, J. L., Severin, G. B., Koestler, B. J. and Waters, C. M. (2014). The Vibrio cholerae diguanylate cyclase VCA0965 has an AGDEF active site and synthesizes cyclic di-GMP. BMC Microbiol 14: 22.
  6. Sambanthamoorthy, K., Luo, C., Pattabiraman, N., Feng, X., Koestler, B., Waters, C. M. and Palys, T. J. (2014). Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development. Biofouling 30(1): 17-28.
  7. Rudlaff, R. M. and Waters, C. M. (2014). What is the role of cyclic di-GMP signaling within the human gut microbiome? Microbiome Science and Medicine 1(1).
  8. Srivastava, D., Hsieh, M. L., Khataokar, A., Neiditch, M. B. and Waters, C. M. (2013). Cyclic di-GMP inhibits Vibrio cholerae motility by repressing induction of transcription and inducing extracellular polysaccharide production. Mol Microbiol 90(6): 1262-1276.
  9. Bai, Y., Yang, J., Eisele, L. E., Underwood, A. J., Koestler, B. J., Waters, C. M., Metzger, D. W. and Bai, G. (2013). Two DHH subfamily 1 proteins in Streptococcus pneumoniae possess cyclic di-AMP phosphodiesterase activity and affect bacterial growth and virulence. J Bacteriol 195(22): 5123-5132.
  10. Koestler, B. J. and Waters, C. M. (2013). Exploring environmental control of cyclic di-GMP signaling in Vibrio cholerae by using the ex vivo lysate cyclic di-GMP assay (TELCA). Appl Environ Microbiol 79(17): 5233-5241.
  11. Zhao, X., Koestler, B. J., Waters, C. M. and Hammer, B. K. (2013). Post-transcriptional activation of a diguanylate cyclase by quorum sensing small RNAs promotes biofilm formation in Vibrio cholerae. Mol Microbiol 89(5): 989-1002.
  12. Xu, J., Kim, J., Koestler, B. J., Choi, J. H., Waters, C. M. and Fuqua, C. (2013). Genetic analysis of Agrobacterium tumefaciens unipolar polysaccharide production reveals complex integrated control of the motile-to-sessile switch. Mol Microbiol 89(5): 929-948.
  13. Agostoni, M., Koestler, B. J., Waters, C. M., Williams, B. L. and Montgomery, B. L. (2013). Occurrence of cyclic di-GMP-modulating output domains in cyanobacteria: an illuminating perspective. MBio 4(4).
  14. Barker, J. R., Koestler, B. J., Carpenter, V. K., Burdette, D. L., Waters, C. M., Vance, R. E. and Valdivia, R. H. (2013). STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. MBio 4(3): e00018-00013.
  15. Edmunds, A. C., Castiblanco, L. F., Sundin, G. W. and Waters, C. M. (2013). Cyclic Di-GMP modulates the disease progression of Erwinia amylovora. J Bacteriol 195(10): 2155-2165.
  16. Amarasinghe, J. J., D'Hondt, R. E., Waters, C. M. and Mantis, N. J. (2013). Exposure of Salmonella enterica Serovar typhimurium to a protective monoclonal IgA triggers exopolysaccharide production via a diguanylate cyclase-dependent pathway. Infect Immun 81(3): 653-664.
  17. Waters, C. M. (2013). Bacterial wheel locks: extracellular polysaccharide inhibits flagellar rotation. J Bacteriol 195(3): 409-410.
  18. Bellows, L. E., Koestler, B. J., Karaba, S. M., Waters, C. M. and Lathem, W. W. (2012). Hfq-dependent, co-ordinate control of cyclic diguanylate synthesis and catabolism in the plague pathogen Yersinia pestis. Mol Microbiol 86(3): 661-674.
  19. Sambanthamoorthy, K., Sloup, R. E., Parashar, V., Smith, J. M., Kim, E. E., Semmelhack, M. F., Neiditch, M. B. and Waters, C. M. (2012). Identification of small molecules that antagonize diguanylate cyclase enzymes to inhibit biofilm formation. Antimicrob Agents Chemother 56(10): 5202-5211.
  20. Srivastava, D. and Waters, C. M. (2012). A tangled web: regulatory connections between quorum sensing and cyclic Di-GMP. J Bacteriol 194(17): 4485-4493.
  21. Massie, J. P., Reynolds, E. L., Koestler, B. J., Cong, J. P., Agostoni, M. and Waters, C. M. (2012). Quantification of high-specificity cyclic diguanylate signaling. Proc Natl Acad Sci U S A 109(31): 12746-12751.
  22. Al Safadi, R., Abu-Ali, G. S., Sloup, R. E., Rudrik, J. T., Waters, C. M., Eaton, K. A. and Manning, S. D. (2012). Correlation between in vivo biofilm formation and virulence gene expression in Escherichia coli O104: H4. PLoS One 7(7): e41628.
  23. Purcell, E. B., McKee, R. W., McBride, S. M., Waters, C. M. and Tamayo, R. (2012). Cyclic diguanylate inversely regulates motility and aggregation in Clostridium difficile. J Bacteriol 194(13): 3307-3316.
  24. Beckmann, B. E., Knoester, D. B., Connelly, B. D., Waters, C. M. and McKinley, P. K. (2012). Evolution of resistance to quorum quenching in digital organisms. Artif Life 18(3): 291-310.
  25. Waters, C. M. (2012). The meteoric rise of the signaling molecule cyclic di-GMP. Microbe Wash DC 7(8): 353-359.
  26. Srivastava, D., Harris, R. C. and Waters, C. M. (2011). Integration of cyclic di-GMP and quorum sensing in the control of vpsT and aphA in Vibrio cholerae. J Bacteriol 193(22): 6331-6341.
  27. Sambanthamoorthy, K., Gokhale, A. A., Lao, W., Parashar, V., Neiditch, M. B., Semmelhack, M. F., Lee, I. and Waters, C. M. (2011). Identification of a novel benzimidazole that inhibits bacterial biofilm formation in a broad-spectrum manner. Antimicrob Agents Ch 55(9): 4369-4378.
  28. Bobrov, A. G., Kirillina, O., Ryjenkov, D. A., Waters, C. M., Price, P. A., Fetherston, J. D., Mack, D., Goldman, W. E., Gomelsky, M. and Perry, R. D. (2011). Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis. Mol Microbiol 79(2): 533-551.
  29. Waters, C. M., Wu, J. T., Ramsey, M. E., Harris, R. C. and Bassler, B. L. (2010). Control of the type 3 secretion system in Vibrio harveyi by quorum sensing through repression of ExsA. Appl Environ Microb 76(15): 4996-5004.
Protocols by Christopher M. Waters
  1. A Filter Binding Assay to Quantify the Association of Cyclic di-GMP to Proteins