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Pablo Gastaminza


Ph.D. in Molecular Biology, Universidad Autónoma de Madrid, 2003

Current position

Ramón y Cajal Fellow at Department of Cellular and Molecular Biology, Centro Nacional de Biotecnología (CSIC), Madrid, Spain

Publications (since 2005)

  1. Mingorance, L., Friesland, M., Coto-Llerena, M., Perez-del-Pulgar, S., Boix, L., Lopez-Oliva, J. M., Bruix, J., Forns, X. and Gastaminza, P. (2014). Selective inhibition of hepatitis C virus infection by hydroxyzine and benztropine. Antimicrob Agents Chemother 58(6): 3451-3460.
  2. Carnero, E., Diez, J., Fortes, P., Gastaminza, P., Majano, P., Martinez, M. A., Perez-del-Pulgar, S., Quer, J., Lopez-Labrador, F. X. and Grupo de Estudio de Hepatitis Viricas de la Sociedad Espanola de, V. (2013). Meeting report: 20 years after the first international symposium on hepatitis C virus and related viruses. Gastroenterol Hepatol 36(10): 641-646.
  3. Larrea, E., Riezu-Boj, J. I., Aldabe, R., Guembe, L., Echeverria, I., Balasiddaiah, A., Gastaminza, P., Civeira, M. P., Sarobe, P. and Prieto, J. (2014). Dysregulation of interferon regulatory factors impairs the expression of immunostimulatory molecules in hepatitis C virus genotype 1-infected hepatocytes. Gut 63(4): 665-673. 
  4. Friesland, M., Mingorance, L., Chung, J., Chisari, F. V. and Gastaminza, P. (2013). Sigma-1 receptor regulates early steps of viral RNA replication at the onset of hepatitis C virus infection. J Virol 87(11): 6377-6390.
  5. Polyak, S. J., Morishima, C., Scott, J. D., Gastaminza, P., Cox, A., de Araujo, E. S., Higgs, M. R., Loo, Y. M., Golden-Mason, L., Lindenbach, B. D., Baumert, T. F., Randall, G. and Gale, M., Jr. (2012). A summary of the 18th international symposium on hepatitis C virus and related viruses. Gastroenterology 142(1): e1-5.
  6. Montero, A., Gastaminza, P., Law, M., Cheng, G., Chisari, F. V. and Ghadiri, M. R. (2011). Self-assembling peptide nanotubes with antiviral activity against hepatitis C virus. Chem Biol 18(11): 1453-1462. Índice de impacto: 5.7 Citas en otros artículos: 13
  7. Gastaminza, P., Pitram, S. M., Dreux, M., Krasnova, L. B., Whitten-Bauer, C., Dong, J., Chung, J., Fokin, V. V., Sharpless, K. B. and Chisari, F. V. (2011). Antiviral stilbene 1,2-diamines prevent initiation of hepatitis C virus RNA replication at the outset of infection. J Virol 85(11): 5513-5523.
  8. Gastaminza, P.*, Dryden, K. A.*, Boyd, B., Wood, M. R., Law, M., Yeager, M. and Chisari, F. V. (2010). Ultrastructural and biophysical characterization of hepatitis C virus particles produced in cell culture. J Virol 84(21): 10999-11009.
  9. Takahashi, K., Asabe, S., Wieland, S., Garaigorta, U., Gastaminza, P., Isogawa, M. and Chisari, F. V. (2010). Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection. Proc Natl Acad Sci U S A 107(16): 7431-7436.
  10. Gastaminza, P., Whitten-Bauer, C. and Chisari, F. V. (2010). Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection. Proc Natl Acad Sci U S A 107(1): 291-296.
  11. Dreux, M., Gastaminza, P., Wieland, S. F. and Chisari, F. V. (2009). The autophagy machinery is required to initiate hepatitis C virus replication. Proc Natl Acad Sci U S A 106(33): 14046-14051.
  12. Jorba, N., Juarez, S., Torreira, E., Gastaminza, P., Zamarreno, N., Albar, J. P. and Ortin, J. (2008). Analysis of the interaction of influenza virus polymerase complex with human cell factors. Proteomics 8(10): 2077-2088.
  13. Gastaminza, P., Cheng, G., Wieland, S., Zhong, J., Liao, W. and Chisari, F. V. (2008). Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion. J Virol 82(5): 2120-2129.
  14. Cheng, G., Montero, A., Gastaminza, P., Whitten-Bauer, C., Wieland, S. F., Isogawa, M., Fredericksen, B., Selvarajah, S., Gallay, P. A., Ghadiri, M. R. and Chisari, F. V. (2008). A virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A 105(8): 3088-3093.
  15. Law, M., Maruyama, T., Lewis, J., Giang, E., Tarr, A. W., Stamataki, Z., Gastaminza, P., Chisari, F. V., Jones, I. M., Fox, R. I., Ball, J. K., McKeating, J. A., Kneteman, N. M. and Burton, D. R. (2008). Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nat Med 14(1): 25-27.
  16. Gastaminza, P., Kapadia, S. B. and Chisari, F. V. (2006). Differential biophysical properties of infectious intracellular and secreted hepatitis C virus particles. J Virol 80(22): 11074-11081.
  17. Zhong, J., Gastaminza, P., Chung, J., Stamataki, Z., Isogawa, M., Cheng, G., McKeating, J. A. and Chisari, F. V. (2006). Persistent hepatitis C virus infection in vitro: coevolution of virus and host. J Virol 80(22): 11082-11093.
  18. Zhong, J.*, Gastaminza, P.*, Cheng, G., Kapadia, S., Kato, T., Burton, D. R., Wieland, S. F., Uprichard, S. L., Wakita, T. and Chisari, F. V. (2005). Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A 102(26): 9294-9299. (*Equal contribution)
Protocols by Pablo Gastaminza
  1. Infection Experiments (Hepatitis C Virus)