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Martina Friesland


Certified Technician in Spain, “Técnico Superior en Laboratorio Diagnóstico Clínico”-“High-Level Technician in Laboratories of Clinical Diagnostics” Vocational training at the IES Benjamín Rúa High School, Madrid, Spain, 2014
Certified Technician in Germany, “Staatlich anerkannte biologisch-technische Assistentin”- “Biologic-technical Assistent recognized by the state“ Vocational training at the Dr. Heinemann Vocational School, Braunschweig, Germany, 2007

Current position

Technician at Department of Cellular and Molecular Biology, the National Center of Biotechnology, Madrid, Spain (since 2011)
Group leader: Dr. Pablo Gastaminza Landart


  1. Doerrbecker, J., Friesland, M., Riebesehl, N., Ginkel, C., Behrendt, P., Brown, R. J., Ciesek, S., Wedemeyer, H., Sarrazin, C., Kaderali, L., Pietschmann, T. and Steinmann, E. (2014). Incorporation of primary patient-derived glycoproteins into authentic infectious hepatitis C virus particles. Hepatology 60(2): 508-520.
  2. Mingorance, L., Friesland, M., Coto-Llerena, M., Perez-del-Pulgar, S., Boix, L., Lopez-Oliva, J. M., Bruix, J., Forns, X. and Gastaminza, P. (2014). Selective inhibition of hepatitis C virus infection by hydroxyzine and benztropine. Antimicrob Agents Chemother 58(6): 3451-3460.
  3. Steinmann, E., Doerrbecker, J., Friesland, M., Riebesehl, N., Ginkel, C., Hillung, J., Gentzsch, J., Lauber, C., Brown, R., Frentzen, A. and Pietschmann, T. (2013). Characterization of hepatitis C virus intra- and intergenotypic chimeras reveals a role of the glycoproteins in virus envelopment. J Virol 87(24): 13297-13306.
  4. Pfaender, S., Heyden, J., Friesland, M., Ciesek, S., Ejaz, A., Steinmann, J., Steinmann, J., Malarski, A., Stoiber, H., Tsiavaliaris, G., Bader, W., Jahreis, G., Pietschmann, T. and Steinmann, E. (2013). Inactivation of hepatitis C virus infectivity by human breast milk. J Infect Dis 208(12): 1943-1952.
  5. Doerrbecker, J., Meuleman, P., Kang, J., Riebesehl, N., Wilhelm, C., Friesland, M., Pfaender, S., Steinmann, J., Pietschmann, T. and Steinmann, E. (2013). Thermostability of seven hepatitis C virus genotypes in vitro and in vivo. J Viral Hepat 20(7): 478-485.
  6. Gentzsch, J., Brohm, C., Steinmann, E., Friesland, M., Menzel, N., Vieyres, G., Perin, P. M., Frentzen, A., Kaderali, L. and Pietschmann, T. (2013). Hepatitis c virus p7 is critical for capsid assembly and envelopment. PLoS Pathog 9(5): e1003355.
  7. Friesland, M., Mingorance, L., Chung, J., Chisari, F. V. and Gastaminza, P. (2013). Sigma-1 receptor regulates early steps of viral RNA replication at the onset of hepatitis C virus infection. J Virol 87(11): 6377-6390.
  8. Vieyres, G., Brohm, C., Friesland, M., Gentzsch, J., Wolk, B., Roingeard, P., Steinmann, E. and Pietschmann, T. (2013). Subcellular localization and function of an epitope-tagged p7 viroporin in hepatitis C virus-producing cells. J Virol 87(3): 1664-1678.
  9. Steinmann, E., Gravemann, U., Friesland, M., Doerrbecker, J., Muller, T. H., Pietschmann, T. and Seltsam, A. (2013). Two pathogen reduction technologies--methylene blue plus light and shortwave ultraviolet light--effectively inactivate hepatitis C virus in blood products. Transfusion 53(5): 1010-1018.
  10. Doerrbecker, J., Friesland, M., Ciesek, S., Erichsen, T. J., Mateu-Gelabert, P., Steinmann, J., Steinmann, J., Pietschmann, T. and Steinmann, E. (2011). Inactivation and survival of hepatitis C virus on inanimate surfaces. J Infect Dis 204(12): 1830-1838.
  11. Steinmann, E., Ciesek, S., Friesland, M., Erichsen, T. J. and Pietschmann, T. (2011). Prolonged survival of hepatitis C virus in the anesthetic propofol. Clin Infect Dis 53(9): 963-964.
  12. Ciesek, S., von Hahn, T., Colpitts, C. C., Schang, L. M., Friesland, M., Steinmann, J., Manns, M. P., Ott, M., Wedemeyer, H., Meuleman, P., Pietschmann, T. and Steinmann, E. (2011). The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry. Hepatology 54(6): 1947-1955. 
  13. Frentzen, A., Huging, K., Bitzegeio, J., Friesland, M., Haid, S., Gentzsch, J., Hoffmann, M., Lindemann, D., Zimmer, G., Zielecki, F., Weber, F., Steinmann, E. and Pietschmann, T. (2011). Completion of hepatitis C virus replication cycle in heterokaryons excludes dominant restrictions in human non-liver and mouse liver cell lines. PLoS Pathog 7(4): e1002029.
  14. Burgel, B., Friesland, M., Koch, A., Manns, M. P., Wedemeyer, H., Weissenborn, K., Schulz-Schaeffer, W. J., Pietschmann, T., Steinmann, E. and Ciesek, S. (2011). Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration. J Viral Hepat 18(8): 562-570.
  15. Ciesek, S., Friesland, M., Steinmann, J., Becker, B., Wedemeyer, H., Manns, M. P., Steinmann, J., Pietschmann, T. and Steinmann, E. (2010). How stable is the hepatitis C virus (HCV)? Environmental stability of HCV and its susceptibility to chemical biocides. J Infect Dis 201(12): 1859-1866.
  16. Bankwitz, D., Steinmann, E., Bitzegeio, J., Ciesek, S., Friesland, M., Herrmann, E., Zeisel, M. B., Baumert, T. F., Keck, Z.-y. and Foung, S. K. (2010). Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes. J Virol 84(11): 5751-5763.
  17. Steinmann, J., Becker, B., Bischoff, B., Paulmann, D., Friesland, M., Pietschmann, T., Steinmann, J. and Steinmann, E. (2010). Virucidal activity of 2 alcohol-based formulations proposed as hand rubs by the World Health Organization. Am J Infect Control 38(1): 66-68.
  18. Brohm, C., Steinmann, E., Friesland, M., Lorenz, I. C., Patel, A., Penin, F., Bartenschlager, R. and Pietschmann, T. (2009). Characterization of determinants important for hepatitis C virus p7 function in morphogenesis by using trans-complementation. J Virol 83(22): 11682-11693.
Protocols by Martina Friesland
  1. Infection Experiments (Hepatitis C Virus)