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Li Chen

Education

Ph.D., Department of Health Science and Technology, Aalborg University, Denmark, 2005

Current position

Assistant Professor in Clinical Molecular Endocrinology Laboratory, Department of Endocrinology, University of Odense, Odense, Denmark

Publications

  1. Wang, L., Fan, J., Lin, Y. S., Guo, Y. S., Gao, B., Shi, Q. Y., Wei, B. Y., Chen, L., Yang, L., Liu, J. and Luo, Z. J. (2015). Glucocorticoids induce autophagy in rat bone marrow mesenchymal stem cells. Mol Med Rep 11(4): 2711-2716.
  2. Hamam, D., Ali, D., Vishnubalaji, R., Hamam, R., Al-Nbaheen, M., Chen, L., Kassem, M., Aldahmash, A. and Alajez, N. M. (2014). microRNA-320/RUNX2 axis regulates adipocytic differentiation of human mesenchymal (skeletal) stem cells. Cell Death Dis 5: e1499.
  3. Twine, N. A., Chen, L., Pang, C. N., Wilkins, M. R. and Kassem, M. (2014). Identification of differentiation-stage specific markers that define the ex vivo osteoblastic phenotype. Bone 67: 23-32.
  4. Chen, L., Holmstrom, K., Qiu, W., Ditzel, N., Shi, K., Hokland, L. and Kassem, M. (2014). MicroRNA-34a inhibits osteoblast differentiation and in vivo bone formation of human stromal stem cells. Stem Cells 32(4): 902-912.
  5. Kristensen, L. P.*, Chen, L.*, Nielsen, M. O., Qanie, D. W., Kratchmarova, I., Kassem, M. and Andersen, J. S. (2012). Temporal profiling and pulsed SILAC labeling identify novel secreted proteins during ex vivo osteoblast differentiation of human stromal stem cells. Mol Cell Proteomics 11(10): 989-1007. (*Co-first author)
  6. Taipaleenmaki, H., Harkness, L., Chen, L., Larsen, K. H., Saamanen, A. M., Kassem, M. and Abdallah, B. M. (2012). The crosstalk between transforming growth factor-beta1 and delta like-1 mediates early chondrogenesis during embryonic endochondral ossification. Stem Cells 30(2): 304-313.
  7. Taipaleenmaki, H., Bjerre Hokland, L., Chen, L., Kauppinen, S. and Kassem, M. (2012). Mechanisms in endocrinology: micro-RNAs: targets for enhancing osteoblast differentiation and bone formation. Eur J Endocrinol 166(3): 359-371.
  8. Qiu, W., Chen, L. and Kassem, M. (2011). Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells. Biochem Biophys Res Commun 413(1): 98-104.
  9. Andersen, D. C., Kortesidis, A., Zannettino, A. C., Kratchmarova, I., Chen, L., Jensen, O. N., Teisner, B., Gronthos, S., Jensen, C. H. and Kassem, M. (2011). Development of novel monoclonal antibodies that define differentiation stages of human stromal (mesenchymal) stem cells. Mol Cells 32(2): 133-142.
  10. Choksi, S.*, Lin, Y.*, Pobezinskaya, Y.*, Chen, L., Park, C., Morgan, M., Li, T., Jitkaew, S., Cao, X., Kim, Y. S., Kim, H. S., Levitt, P., Shih, G., Birre, M., Deng, C. X. and Liu, Z. G. (2011). A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2. Mol Cell 42(5): 597-609. (*Co-first author)
  11. Chen, L., Qanie, D., Jafari, A., Taipaleenmaki, H., Jensen, C. H., Saamanen, A. M., Sanz, M. L., Laborda, J., Abdallah, B. M. and Kassem, M. (2011). Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway. J Biol Chem 286(37): 32140-32149.
  12. Zou, L., Zou, X., Chen, L., Li, H., Mygind, T., Kassem, M. and Bunger, C. (2008). Multilineage differentiation of porcine bone marrow stromal cells associated with specific gene expression pattern. J Orthop Res 26(1): 56-64.
  13. Zou, L., Zou, X., Chen, L., Li, H., Mygind, T., Kassem, M. and Bunger, C. (2008). Effect of hyaluronan on osteogenic differentiation of porcine bone marrow stromal cells in vitro. J Orthop Res 26(5): 713-720.
  14. Chen, L., Fink, T., Ebbesen, P. and Zachar, V. (2006). Temporal transcriptome of mouse ATDC5 chondroprogenitors differentiating under hypoxic conditions. Exp Cell Res 312(10): 1727-1744.
  15. Chen, L., Fink, T., Ebbesen, P. and Zachar, V. (2006). Optimized chondrogenesis of ATCD5 cells through sequential regulation of oxygen conditions. Tissue Eng 12(3): 559-567.
  16. Chen, L., Fink, T., Ebbesen, P. and Zachar, V. (2006). Hypoxic treatment inhibits insulin-induced chondrogenesis of ATDC5 cells despite upregulation of DEC1. Connect Tissue Res 47(3): 119-123.
  17. Hong, J., Chen, L., Jeppesen, P. B., Nordentoft, I. and Hermansen, K. (2006). Stevioside counteracts the alpha-cell hypersecretion caused by long-term palmitate exposure. Am J Physiol Endocrinol Metab 290(3): E416-422.
  18. Foster, L. J., Zeemann, P. A., Li, C., Mann, M., Jensen, O. N. and Kassem, M. (2005). Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation. Stem Cells 23(9): 1367-1377.
  19. Chen, L., Fink, T., Zhang, X., Ebbesen, P. and Zachar, V. (2005). Temporal analysis of a selected transcriptome during of mouse ATDC5 progenitors. Differentiation 73: 350-63.
  20. Zou, X., Li, H., Chen, L., Baatrup, A., Bunger, C. and Lind, M. (2004). Stimulation of porcine bone marrow stromal cells by hyaluronan, dexamethasone and rhBMP-2. Biomaterials 25(23): 5375-5385.
  21. Chen, L., Ma, S., Li, B., Fink, T., Zachar, V., Takahashi, M., Cuttichia, J., Tsui, L. C., Ebbesen, P. and Liu, X. (2003). Transcriptional activation of immediate-early gene ETR101 by human T-cell leukaemia virus type I Tax. J Gen Virol 84(Pt 12): 3203-3214.
  22. Xiang, B., Yu, G. H., Guo, J., Chen, L., Hu, W., Pei, G. and Ma, L. (2001). Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization. J Biol Chem 276(7): 4709-4716.
  23. Chen, L., Xu, Q., Liu, X. L., Zhao, J. and Ma, L. (1999). Differential and tissue-specific expression of mitochondrial elongation factor Tu and Ts during development. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 31(1): 37-40. (In Chinese)
  24. Yang, R., Lu, S. D., Zheng, Z. L., Zhao, J., Zhang, X. N., Chen, L., Pei, G. and Ma, L. (1998). Expression of opioid-receptor-like receptor (ORL1) gene in rat brain. Sheng Li Xue Bao 50(2): 139-144. (In Chinese)
Protocols by Li Chen
  1. In vivo Heterotopic Bone Formation Assay Using Isolated Mouse and Human Mesenchymal Stem Cells