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Michel Perron


Ph.D. in Virology, Harvard Medical School, Boston, Massachusetts, 2007

Current position

Senior Research Scientist, Biology Department, Gilead Sciences, Foster City, California

Publications (since 2005)

  1. Mackman, R. L., Sangi, M., Sperandio, D., Parrish, J. P., Eisenberg, E., Perron, M., Hui, H., Zhang, L., Siegel, D., Yang, H., Saunders, O., Boojamra, C., Lee, G., Samuel, D., Babaoglu, K., Carey, A., Gilbert, B. E., Piedra, P. A., Strickley, R., Iwata, Q., Hayes, J., Stray, K., Kinkade, A., Theodore, D., Jordan, R., Desai, M. C. and Cihlar, T. (2015). Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study. J Med Chem. (Epub ahead of print)
  2. Diaz-Griffero, F., Perron, M., McGee-Estrada, K., Hanna, R., Maillard, P. V., Trono, D. and Sodroski, J. (2008). A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus. Virology 378(2): 233-242.
  3. Diaz-Griffero, F., Kar, A., Perron, M., Xiang, S. H., Javanbakht, H., Li, X. and Sodroski, J. (2007). Modulation of retroviral restriction and proteasome inhibitor-resistant turnover by changes in the TRIM5alpha B-box 2 domain. J Virol 81(19): 10362-10378.
  4. Ulm, J., Perron, M., Sodroski, J. and C Mulligan, R. (2007). Complex determinants within the Moloney murine leukemia virus capsid modulate susceptibility of the virus to Fv1 and Ref1-mediated restriction. Virology 363(2): 245-255.
  5. Perron, M. J., Stremlau, M., Lee, M., Javanbakht, H., Song, B. and Sodroski, J. (2007). The human TRIM5alpha restriction factor mediates accelerated uncoating of the N-tropic murine leukemia virus capsid. J Virol 81(5): 2138-2148.
  6.  Javanbakht, H., An, P., Gold, B., Petersen, D. C., O'Huigin, C., Nelson, G. W., O'Brien, S. J., Kirk, G. D., Detels, R., Buchbinder, S., Donfield, S., Shulenin, S., Song, B., Perron, M. J., Stremlau, M., Sodroski, J., Dean, M. and Winkler, C. (2006). Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection. Virology 354(1): 15-27.
  7. Li, X., Li, Y., Stremlau, M., Yuan, W., Song, B., Perron, M. and Sodroski, J. (2006). Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. J Virol 80(13): 6198-6206.
  8. Stremlau, M., Song, B., Javanbakht, H., Perron, M. and Sodroski, J. (2006). Cyclophilin A: an auxiliary but not necessary cofactor for TRIM5α restriction of HIV-1. Virology 351(1): 112-120.
  9. Perron, M. J., Stremlau, M. and Sodroski, J. (2006). Two surface-exposed elements of the B30. 2/SPRY domain as potency determinants of N-tropic murine leukemia virus restriction by human TRIM5α. J Virol 80(11): 5631-5636.
  10. Si, Z., Vandegraaff, N., O'Huigin, C., Song, B., Yuan, W., Xu, C., Perron, M., Li, X., Marasco, W. A., Engelman, A., Dean, M. and Sodroski, J. (2006). Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection. Proc Natl Acad Sci U S A 103(19): 7454-7459.
  11. Stremlau, M.*, Perron, M.*, Lee, M., Li, Y., Song, B., Javanbakht, H., Diaz-Griffero, F., Anderson, D. J., Sundquist, W. I. and Sodroski, J. (2006). Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor. Proc Natl Acad Sci U S A 103(14): 5514-5519. (*These authors contributed equally)
  12. Song, B., Javanbakht, H., Perron, M., Park, D. H., Stremlau, M. and Sodroski, J. (2005). Retrovirus restriction by TRIM5alpha variants from Old World and New World primates. J Virol 79(7): 3930-3937.
  13.  Stremlau, M., Perron, M., Welikala, S. and Sodroski, J. (2005). Species-specific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction. J Virol 79(5): 3139-3145.
  14. Sherman, W. A., Blouse, G. E., Perron, M. J., Tran, T., Shore, J. D. and Gafni, A. (2005). Enthalpy measurement using calorimetry shows a significant difference in potential energy between the active and latent conformations of PAI-1. Biol Chem 386(2): 111-116.
Protocols by Michel Perron
  1. Determination of Mitochondrial DNA Upon Drug Treatment