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Thomas A Hughes


Ph.D. in Molecular and Cell Biology, Oxford University, UK, 1996

Current position

Associate Professor of Cancer Biology, School of Medicine, University of Leeds

Publications (since 2009)

  1. Hayes, J., Thygesen, H., Bellamy, C., Droop, A., Boissinot, M., Hughes, T. A., Westhead, D., Alder, J. E., Shaw, L. and Short, S. C. (2014). Prediction of clinical outcome in glioblastoma using a biologically relevant nine-microRNA signature. Mol Oncol.
  2. Langlands, F. E., Dodwell, D., Hanby, A. M., Horgan, K., Millican-Slater, R. A., Speirs, V., Verghese, E. T., Smith, L. and Hughes, T. A. (2014). PSMD9 expression predicts radiotherapy response in breast cancer. Mol Cancer 13: 73.
  3. Verghese, E. T., Drury, R., Green, C. A., Holliday, D. L., Lu, X., Nash, C., Speirs, V., Thorne, J. L., Thygesen, H. H., Zougman, A., Hull, M. A., Hanby, A. M. and Hughes, T. A. (2013). MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion. J Pathol 231(3): 388-399.
  4. Kim, B., Fatayer, H., Hanby, A. M., Horgan, K., Perry, S. L., Valleley, E. M., Verghese, E. T., Williams, B. J., Thorne, J. L. and Hughes, T. A. (2013). Neoadjuvant chemotherapy induces expression levels of breast cancer resistance protein that predict disease-free survival in breast cancer. PLoS One 8(5): e62766.
  5. Tiernan, J. P., Perry, S. L., Verghese, E. T., West, N. P., Yeluri, S., Jayne, D. G. and Hughes, T. A. (2013). Carcinoembryonic antigen is the preferred biomarker for in vivo colorectal cancer targeting. Br J Cancer 108(3): 662-667.
  6. Cookson, V. J., Bentley, M. A., Hogan, B. V., Horgan, K., Hayward, B. E., Hazelwood, L. D. and Hughes, T. A. (2012). Circulating microRNA profiles reflect the presence of breast tumours but not the profiles of microRNAs within the tumours. Cell Oncol (Dordr) 35(4): 301-308.
  7. Drury, R., Verghese, E. T. and Hughes, T. A. (2012). The roles of microRNAs in sarcomas. J Pathol 227(4): 385-391.
  8. Tiernan, J. P., Ansari, I., Hirst, N. A., Millner, P. A., Hughes, T. A. and Jayne, D. G. (2012). Intra-operative tumour detection and staging in colorectal cancer surgery. Colorectal Dis 14(9): e510-520.
  9. Verghese, E. T., Shenoy, H., Cookson, V. J., Green, C. A., Howarth, J., Partanen, R. H., Pollock, S., Waterworth, A., Speirs, V., Hughes, T. A. and Hanby, A. M. (2011). Epithelial-mesenchymal interactions in breast cancer: evidence for a role of nuclear localized beta-catenin in carcinoma-associated fibroblasts. Histopathology 59(4): 609-618.
  10. Hogan, B. V., Peter, M. B., Achuthan, R., Beaumont, A. J., Langlands, F. E., Shakes, S., Wood, P. M., Shenoy, H. G., Orsi, N. M., Horgan, K., Carter, C. R. and Hughes, T. A. (2011). Perioperative reductions in circulating lymphocyte levels predict wound complications after excisional breast cancer surgery. Ann Surg 253(2): 360-364.
  11. Satheesha, S., Cookson, V. J., Coleman, L. J., Ingram, N., Madhok, B., Hanby, A. M., Suleman, C. A., Sabine, V. S., Macaskill, E. J., Bartlett, J. M., Dixon, J. M., McElwaine, J. N. and Hughes, T. A. (2011). Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer. Mol Cancer 10: 19.
  12. Hogan, B. V., Peter, M. B., Shenoy, H. G., Horgan, K. and Hughes, T. A. (2011). Surgery induced immunosuppression. Surgeon 9(1): 38-43.
  13. Madhok, B. M., Yeluri, S., Perry, S. L., Hughes, T. A. and Jayne, D. G. (2011). Targeting glucose metabolism: an emerging concept for anticancer therapy. Am J Clin Oncol 34(6): 628-635.
  14. Smith, L., Coleman, L. J., Cummings, M., Satheesha, S., Shaw, S. O., Speirs, V. and Hughes, T. A. (2010). Expression of oestrogen receptor beta isoforms is regulated by transcriptional and post-transcriptional mechanisms. Biochem J 429(2): 283-290.
  15. Smith, L., Brannan, R. A., Hanby, A. M., Shaaban, A. M., Verghese, E. T., Peter, M. B., Pollock, S., Satheesha, S., Szynkiewicz, M., Speirs, V. and Hughes, T. A. (2010). Differential regulation of oestrogen receptor beta isoforms by 5' untranslated regions in cancer. J Cell Mol Med 14(8): 2172-2184.
  16. Al-Nakhle, H., Burns, P. A., Cummings, M., Hanby, A. M., Hughes, T. A., Satheesha, S., Shaaban, A. M., Smith, L. and Speirs, V. (2010). Estrogen receptor {beta}1 expression is regulated by miR-92 in breast cancer. Cancer Res 70(11): 4778-4784.
  17. Madhok, B. M., Yeluri, S., Perry, S. L., Hughes, T. A. and Jayne, D. G. (2010). Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells. Br J Cancer 102(12): 1746-1752.
  18. Smith, L., Speirs, V. and Hughes, T. A. (2010). Estrogen receptor regulation: don't forget translation. Breast Cancer Res Treat 121(1): 251-252.
  19. Coleman, L. J., Peter, M. B., Teall, T. J., Brannan, R. A., Hanby, A. M., Honarpisheh, H., Shaaban, A. M., Smith, L., Speirs, V., Verghese, E. T., McElwaine, J. N. and Hughes, T. A. (2009). Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity. Br J Cancer 100(9): 1393-1399.
Protocols by Thomas A Hughes
  1. Three Dimensional Spheroid Co-culture Invasion Assay