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Julia Ladewig


Ph.D. in Biology, Institute of Reconstructive Neurobiology, University of Bonn, 2008

Current position

Independent Junior Group Leader, Institute of Reconstructive Neurobiology, University of Bonn, Germany


  1. Ladewig, J.*, Koch, P.* and Brustle, O. (2014). Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration. Nat Neurosci 17(1): 24-26. (IF: 15.251)
  2.  Ladewig, J.*, Koch, P.* and Brustle, O. (2013). Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies. Nat Rev Mol Cell Biol 14(4): 225-236. (IF: 39,123)
  3. Mertens, J., Stuber, K., Wunderlich, P., Ladewig, J., Kesavan, J. C., Vandenberghe, R., Vandenbulcke, M., van Damme, P., Walter, J., Brustle, O. and Koch, P. (2013). APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based gamma-secretase modulation. Stem Cell Reports 1(6): 491-498. (IF: no IF yet)
  4. Mertens, J., Stuber, K., Poppe, D., Doerr, J., Ladewig, J., Brustle, O.* and Koch, P.* (2013). Embryonic stem cell-based modeling of tau pathology in human neurons. Am J Pathol 182(5): 1769-1779. (IF: 5.224)
  5. Koch, P., Tamboli, I. Y., Mertens, J., Wunderlich, P., Ladewig, J., Stuber, K., Esselmann, H., Wiltfang, J., Brustle, O. and Walter, J. (2012). Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of gamma-secretase activity in endogenous amyloid-beta generation. Am J Pathol 180(6): 2404-2416. (IF: 5.224)
  6. Ladewig, J., Mertens, J.*, Kesavan, J.*, Doerr, J., Poppe, D., Glaue, F., Herms, S., Wernet, P., Kogler, G., Muller, F. J., Koch, P.* and Brustle, O.* (2012). Small molecules enable highly efficient neuronal conversion of human fibroblasts. Nat Methods 9(6): 575-578. (IF: 23.565)
  7. Oki, K.*, Tatarishvili, J.*, Wood, J.*, Koch, P.*, Wattananit, S., Mine, Y., Monni, E., Tornero, D., Ahlenius, H., Ladewig, J., Brustle, O., Lindvall, O. and Kokaia, Z. (2012). Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain. Stem Cells 30(6): 1120-1133. (*Equal contribution) (IF: 7.871)
  8. Falk, A.*, Koch, P.*, Kesavan, J., Takashima, Y., Ladewig, J., Alexander, M., Wiskow, O., Tailor, J., Trotter, M., Pollard, S., Smith, A. and Brustle, O. (2012). Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons. PLoS One 7(1): e29597. (IF: 4.411)
  9. Koch, P., Breuer, P., Peitz, M., Jungverdorben, J., Kesavan, J., Poppe, D., Doerr, J., Ladewig, J., Mertens, J., Tuting, T., Hoffmann, P., Klockgether, T., Evert, B. O., Wullner, U. and Brustle, O. (2011). Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Nature 480(7378): 543-546. (IF: 38.597)
  10. Koch, P., Opitz, T., Steinbeck, J. A., Ladewig, J. and Brustle, O. (2009). A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration. Proc Natl Acad Sci U S A 106(9): 3225-3230. (IF: 9.971)
  11. Ladewig, J.*, Koch, P.*, Endl, E., Meiners, B., Opitz, T., Couillard-Despres, S., Aigner, L. and Brustle, O. (2008). Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons. Stem Cells 26(7): 1705-1712. (*Equal contribution) (IF: 7.871)
  12. Kruger, O., Ladewig, J., Koster, K. and Ragg, H. (2002). Widespread occurrence of serpin genes with multiple reactive centre-containing exon cassettes in insects and nematodes. Gene 293(1-2): 97-105. (IF: 2.196)
Protocols by Julia Ladewig
  1. In vitro Migration Assays for Neural Stem Cells, Intermediate Neurogenic Progenitors and Immature Neurons