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Rocío M. de Pablos

Education

Ph.D. in Biochemistry, Department of Biochemistry and Molecular Biology, University of Seville, 2005

Current position

Assistant Professor in Biochemistry, Department of Biochemistry and Molecular Biology, University of Seville, Spain

Publications (since 2005)

  1. Espinosa-Oliva, A. M., de Pablos, R. M., Sarmiento, M., Villaran, R. F., Carrillo-Jimenez, A., Santiago, M., Venero, J. L., Herrera, A. J., Cano, J. and Machado, A. (2014). Role of dopamine in the recruitment of immune cells to the nigro-striatal dopaminergic structures. Neurotoxicology 41: 89-101.
  2. Espinosa-Oliva, A. M., de Pablos, R. M. and Santiago, M. (2014). In vivo effect of apomorphine and haloperidol on MPP neurotoxicity. Pharmacology 93(3-4): 101-107.
  3. de Pablos, R. M., Herrera, A. J., Espinosa-Oliva, A. M., Sarmiento, M., Munoz, M. F., Machado, A. and Venero, J. L. (2014). Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation. J Neuroinflammation 11: 34.
  4. Machado, A., Herrera, A. J., de Pablos, R. M., Espinosa-Oliva, A. M., Sarmiento, M., Ayala, A., Venero, J. L., Santiago, M., Villaran, R. F., Delgado-Cortes, M. J., Arguelles, S. and Cano, J. (2014). Chronic stress as a risk factor for Alzheimer's disease. Rev Neurosci 25(6): 785-804.
  5. Serres, S., Bristow, C., de Pablos, R. M., Merkler, D., Soto, M. S., Sibson, N. R. and Anthony, D. C. (2013). Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis. J Cereb Blood Flow Metab 33(5): 744-753.
  6. Hernandez-Romero, M. C., Delgado-Cortes, M. J., Sarmiento, M., de Pablos, R. M., Espinosa-Oliva, A. M., Arguelles, S., Bandez, M. J., Villaran, R. F., Maurino, R., Santiago, M., Venero, J. L., Herrera, A. J., Cano, J. and Machado, A. (2012). Peripheral inflammation increases the deleterious effect of CNS inflammation on the nigrostriatal dopaminergic system. Neurotoxicology 33(3): 347-360.
  7. Espinosa-Oliva, A. M., de Pablos, R. M., Villaran, R. F., Arguelles, S., Venero, J. L., Machado, A. and Cano, J. (2011). Stress is critical for LPS-induced activation of microglia and damage in the rat hippocampus. Neurobiol Aging 32(1): 85-102.
  8. Machado, A., Herrera, A. J., Venero, J. L., Santiago, M., De Pablos, R. M., Villaran, R. F., Espinosa-Oliva, A. M., Arguelles, S., Sarmiento, M., Delgado-Cortes, M. J., Maurino, R. and Cano, J. (2011). Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: possible implication in Parkinson's disease incidence. Parkinsons Dis 2011: 393769.
  9. Machado, A., Herrera, A. J., Venero, J. L., Santiago, M., de Pablos, R. M., Villaran, R. F., Espinosa-Oliva, A. M., Arguelles, S., Sarmiento, M., Delgado-Cortes, M. J., Maurino, R. and Cano, J. (2011). Inflammatory animal model for parkinson's disease: the intranigral injection of LPS induced the inflammatory process along with the selective degeneration of nigrostriatal dopaminergic neurons. ISRN Neurol 2011: 476158.
  10. Arguelles, S., Herrera, A. J., Carreno-Muller, E., de Pablos, R. M., Villaran, R. F., Espinosa-Oliva, A. M., Machado, A. and Cano, J. (2010). Degeneration of dopaminergic neurons induced by thrombin injection in the substantia nigra of the rat is enhanced by dexamethasone: role of monoamine oxidase enzyme. Neurotoxicology 31(1): 55-66.
  11. Villaran, R. F., Espinosa-Oliva, A. M., Sarmiento, M., De Pablos, R. M., Arguelles, S., Delgado-Cortes, M. J., Sobrino, V., Van Rooijen, N., Venero, J. L., Herrera, A. J., Cano, J. and Machado, A. (2010). Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease. J Neurochem 114(6): 1687-1700.
  12. Ana, M. Espinosa Oliva, de Pablos R. M., Villarán R. F., Sarmiento S., Herrera, A. J. y and Machado A. (2010). Proaging effects of stress. A review. Approaches to Aging Control 14, 33-54.
  13. Villaran, R. F., de Pablos, R. M., Arguelles, S., Espinosa-Oliva, A. M., Tomas-Camardiel, M., Herrera, A. J., Cano, J. and Machado, A. (2009). The intranigral injection of tissue plasminogen activator induced blood-brain barrier disruption, inflammatory process and degeneration of the dopaminergic system of the rat. Neurotoxicology 30(3): 403-413.
  14. Hernandez-Romero, M. C., Arguelles, S., Villaran, R. F., de Pablos, R. M., Delgado-Cortes, M. J., Santiago, M., Herrera, A. J., Cano, J. and Machado, A. (2008). Simvastatin prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide. J Neurochem 105(2): 445-459.
  15. Herrera, A. J., de Pablos, R. M., Carreno-Muller, E., Villaran, R. F., Venero, J. L., Tomas-Camardiel, M., Cano, J. and Machado, A. (2008). The intrastriatal injection of thrombin in rat induced a retrograde apoptotic degeneration of nigral dopaminergic neurons through synaptic elimination. J Neurochem 105(3): 750-762.
  16. Villaran, R. F., Tomas-Camardiel, M., de Pablos, R. M., Santiago, M., Herrera, A. J., Navarro, A., Machado, A. and Cano, J. (2008). Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production. Neurotoxicology 29(2): 244-258.
  17. de alzheimer. R. F. Villarán, R. M. de Pablos, S. Argüelles, A. J. Herrera, J. L. Venero, A. Ayala, J. Cano y A. Machado. (2007). El estrés y la inflamación en la enfermedad. Medicina Antienvejecimiento 10, 25-26.
  18. de Pablos, R. M., Villaran, R. F., Arguelles, S., Herrera, A. J., Venero, J. L., Ayala, A., Cano, J. and Machado, A. (2006). Stress increases vulnerability to inflammation in the rat prefrontal cortex. J Neurosci 26(21): 5709-5719.
  19. Tomas-Camardiel, M., Venero, J. L., Herrera, A. J., De Pablos, R. M., Pintor-Toro, J. A., Machado, A. and Cano, J. (2005). Blood-brain barrier disruption highly induces aquaporin-4 mRNA and protein in perivascular and parenchymal astrocytes: protective effect by estradiol treatment in ovariectomized animals. J Neurosci Res 80(2): 235-246.
  20. de Pablos, R. M., Herrera, A. J., Tomas-Camardiel, M., Machado, A. and Cano, J. (2005). Deprenyl enhances the striatal neuronal damage produced by quinolinic acid. Brain Res Mol Brain Res 141(1): 48-57.
Protocols by Rocío M. de Pablos
  1. Creating a Rat Model of Chronic Variate Stress