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Melike  Çağlayan

Melike Çağlayan


Ph.D, Bogazici University, Turkey, 2010

Current position

Research Fellow, GISBL, NIEHS/NIH, US


  1. Caglayan, M., Horton, J. K., Dai, D. P., Stefanick, D. F. and Wilson, S. H. (2017). Oxidized nucleotide insertion by pol beta confounds ligation during base excision repair. Nat Commun 8: 14045.
  2. Sassa, A., Caglayan, M., Rodriguez, Y., Beard, W. A., Wilson, S. H., Nohmi, T., Honma, M. and Yasui, M. (2016). Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine. J Biol Chem 291(46): 24314-24323.
  3. Caglayan, M. and Wilson, S. H. (2015). Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair. DNA Repair (Amst) 35: 85-89.
  4. Caglayan, M., Horton, J. K., Prasad, R. and Wilson, S. H. (2015). Complementation of aprataxin deficiency by base excision repair enzymes. Nucleic Acids Res 43(4): 2271-2281.
  5. Caglayan, M., Batra, V. K., Sassa, A., Prasad, R. and Wilson, S. H. (2014). Role of polymerase beta in complementing aprataxin deficiency during abasic-site base excision repair. Nat Struct Mol Biol 21(5): 497-499.
  6. Sassa, A., Caglayan, M., Dyrkheeva, N. S., Beard, W. A. and Wilson, S. H. (2014). Base excision repair of tandem modifications in a methylated CpG dinucleotide. J Biol Chem 289(20): 13996-14008.
  7. Caglayan, M. and Bilgin, N. (2012). Temperature dependence of accuracy of DNA polymerase I from Geobacillus anatolicus. Biochimie 94(9): 1968-1973.
  8. Caglayan, M. and Bilgin, N. (2011). Cloning and sequence analysis of novel DNA polymerases from thermophilic Geobacillus species isolated from hot springs in Turkey: characterization of a DNA polymerase I from Geobacillus kaue strain NB. Appl Biochem Biotechnol 165(5-6): 1188-1200.
Protocols by Melike Çağlayan
  1. Enzymatic Activity Assays in Yeast Cell Extracts
  2. Enzymatic Activity Assays for Base Excision Repair Enzymes in Cell Extracts from Vertebrate Cells
  3. In vitro Assay to Measure DNA Polymerase β Nucleotide Insertion Coupled with the DNA Ligation Reaction during Base Excision Repair