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Chung-Yu  Lan

Chung-Yu Lan


Ph.D. in Microbiology, University of California-Davis, 1998

Current position

Professor, Institute of Molecular and Cellular Biology and Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan

Publications (since 2009)

  1. Lin, C., Lin, C. N., Wang, Y. C., Liu, F. Y., Chuang, Y. J., Lan, C. Y., Hsieh, W. P. and Chen, B. S. (2014). The role of TGF-beta signaling and apoptosis in innate and adaptive immunity in zebrafish: a systems biology approach. BMC Syst Biol 8(1): 116.
  2. Lin, M. F., Lin, Y. Y., Yeh, H. W. and Lan, C. Y.* (2014). Role of the BaeSR two-component system in the regulation of Acinetobacter baumannii adeAB genes and its correlation with tigecycline susceptibility. BMC Microbiol 14: 119. (*Corresponding author)
  3. Tsai, P. W., Cheng, Y. L., Hsieh, W. P. and Lan, C. Y.* (2014). Responses of Candida albicans to the human antimicrobial peptide LL-37. J Microbiol 52(7): 581-589. (*Corresponding author)
  4. Wang, Y. C., Tsai, I. C., Lin, C., Hsieh, W. P., Lan, C. Y., Chuang, Y. J. and Chen, B. S. (2014). Essential functional modules for pathogenic and defensive mechanisms in Candida albicans infections. Biomed Res Int 2014: 136130.
  5. Tsai, P. W., Chen, Y. T., Yang, C. Y., Chen, H. F., Tan, T. S., Lin, T. W., Hsieh, W. P. and Lan, C. Y.* (2014). The role of Mss11 in Candida albicans biofilm formation. Mol Genet Genomics 289(5): 807-819. (*Corresponding author)
  6. Chen, Y. Y., Chao, C. C., Liu, F. C., Hsu, P. C., Chen, H. F., Peng, S. C., Chuang, Y. J., Lan, C. Y., Hsieh, W. P. and Wong, D. S. (2013). Dynamic transcript profiling of Candida albicans infection in zebrafish: a pathogen-host interaction study. PLoS One 8(9): e72483.
  7. Wang, Y. C., Lin, C., Chuang, M. T., Hsieh, W. P., Lan, C. Y., Chuang, Y. J. and Chen, B. S. (2013). Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. BMC Syst Biol 7: 79.
  8. Lin, M. F., Liou, M. L., Tu, C. C., Yeh, H. W. and Lan, C. Y. (2013). Molecular epidemiology of integron-associated antimicrobial gene cassettes in the clinical isolates of Acinetobacter baumannii from northern Taiwan. Ann Lab Med 33(4): 242-247.
  9. Hsu, P. C., Chao, C. C., Yang, C. Y., Ye, Y. L., Liu, F. C., Chuang, Y. J. and Lan, C. Y.* (2013). Diverse Hap43-independent functions of the Candida albicans CCAAT-binding complex. Eukaryot Cell 12(6): 804-815. (*Corresponding author)
  10. Tsai, P. W., Chen, Y. T., Hsu, P. C. and Lan, C. Y.* (2013). Study of Candida albicans and its interactions with the host: A mini review. BioMedicine 3:51-64. (*Corresponding author)
  11. Kuo, Z. Y., Chuang, Y. J., Chao, C. C., Liu, F. C., Lan, C. Y. and Chen, B. S. (2013). Identification of infection- and defense-related genes via a dynamic host-pathogen interaction network using a Candida albicans-zebrafish infection model. J Innate Immun 5(2): 137-152.
  12. Liu, Y. S., Tsai, P. W., Wang, Y., Fan, T. C., Hsieh, C. H., Chang, M. D., Pai, T. W., Huang, C. F., Lan, C. Y. and Chang, H. T. (2012). Chemoattraction of macrophages by secretory molecules derived from cells expressing the signal peptide of eosinophil cationic protein. BMC Syst Biol 6: 105.
  13. Chang, H. T., Tsai, P. W., Huang, H. H., Liu, Y. S., Chien, T. S. and Lan, C. Y. (2012). LL37 and hBD-3 elevate the beta-1,3-exoglucanase activity of Candida albicans Xog1p, resulting in reduced fungal adhesion to plastic. Biochem J 441(3): 963-970.
  14. Chen, Y. T., Lin, C. Y., Tsai, P. W., Yang, C. Y., Hsieh, W. P. and Lan, C. Y.* (2012). Rhb1 regulates the expression of secreted aspartic protease 2 through the TOR signaling pathway in Candida albicans. Eukaryot Cell 11(2): 168-182. (*Corresponding author)
  15. Wang, Y. C., Huang, S. H., Lan, C. Y. and Chen, B. S. (2012). Prediction of phenotype-associated genes via a cellular network approach: a Candida albicans infection case study. PLoS One 7(4): e35339.
  16. Tsai, P.-W., Yang, C.-Y., Chang, H.-T.* and Lan, C.-Y.* (2011). Human antimicrobial peptide LL-37 inhibits adhesion of Candida albicans by interacting with yeast cell-wall carbohydrates. PLoS One 6(3): e17755. (*Corresponding author)
  17. Lin, M. F., Chang, K. C., Lan, C. Y., Chou, J., Kuo, J. W., Chang, C. K. and Liou, M. L. (2011). Molecular epidemiology and antimicrobial resistance determinants of multidrug-resistant Acinetobacter baumannii in five proximal hospitals in Taiwan. Jpn J Infect Dis 64(3): 222-227.
  18. Hsu, P. C., Yang, C. Y. and Lan, C. Y.* (2011). Candida albicans Hap43 is a repressor induced under low-iron conditions and is essential for iron-responsive transcriptional regulation and virulence. Eukaryot Cell 10(2): 207-225. (*Corresponding author)
  19. Tsai, P. W., Yang, C. Y., Chang, H. T.* and Lan, C. Y.* (2011). Characterizing the role of cell-wall beta-1,3-exoglucanase Xog1p in Candida albicans adhesion by the human antimicrobial peptide LL-37. PLoS One 6(6): e21394. (*Corresponding author)
  20. Hsu, J. T., Peng, C. H., Hsieh, W. P., Lan, C. Y.* and Tang, C. Y.* (2011). A novel method to identify cooperative functional modules: study of module coordination in the Saccharomyces cerevisiae cell cycle. BMC Bioinformatics 12: 281. (*Corresponding author)
  21. Yang, S. K., Wang, Y. C., Chao, C. C., Chuang, Y. J., Lan, C. Y. and Chen, B. S. (2010). Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNFalpha-induced inflammatory responses. BMC Med Genomics 3: 19.
  22. Wang, Y. C., Lan, C. Y., Hsieh, W. P., Murillo, L. A., Agabian, N. and Chen, B. S. (2010). Global screening of potential Candida albicans biofilm-related transcription factors via network comparison. BMC Bioinformatics 11: 53.
  23. Chao, C. C., Hsu, P. C., Jen, C. F., Chen, I. H., Wang, C. H., Chan, H. C., Tsai, P. W., Tung, K. C., Wang, C. H., Lan, C. Y.* and Chuang, Y. J.* (2010). Zebrafish as a model host for Candida albicans infection. Infect Immun 78(6): 2512-2521. (*Corresponding author)
  24. Wang, H. Y., Ho, P. C., Lan, C. Y. and Chang, M. D. (2009). Transcriptional regulation of human eosinophil RNase2 by the liver-enriched hepatocyte nuclear factor 4. J Cell Biochem 106(2): 317-326.
  25. Tsao, C. C., Chen, Y. T. and Lan, C. Y.* (2009). A small G protein Rhb1 and a GTPase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicans. Fungal Genet Biol 46(2): 126-136. (*Corresponding author)
Protocols by Chung-Yu Lan
  1. Induction of Tigecycline Resistance in Acinetobacter baumannii
  2. Minimal Inhibitory Concentration (MIC) Assay for Acinetobacter baumannii