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Mervi T. Hyvönen

Education

Ph.D. in Molecular Medicine, Faculty of Medicine, University of Kuopio, Finland, 2008

Current position

Researcher, Biogenic Amines Research Group, School of Pharmacy, University of Eastern Finland, Kuopio, Finland

Publications

  1. Hyvonen, M. T. and Spalding, K. L. (2014). Maintenance of white adipose tissue in man. Int J Biochem Cell Biol. (Epub ahead of print)
  2. Keinanen, T. A., Hyvonen, M. T., Alhonen, L., Vepsalainen, J. and Khomutov, A. R. (2014). Selective regulation of polyamine metabolism with methylated polyamine analogues. Amino Acids 46(3): 605-620.
  3. Weisell, J., Hyvonen, M. T., Alhonen, L., Vepsalainen, J., Keinanen, T. A. and Khomutov, A. R. (2014). Charge deficient analogues of the natural polyamines. Curr Pharm Des 20(2): 262-277.
  4. Khomutov, M., Weisell, J., Hyvönen, M., Keinänen, T., Vepsäläinen, J., Alhonen, L., Khomutov, A. and Kochetkov, S. (2013). Hydroxylamine derivatives for regulation of spermine and spermidine metabolism. Biochemistry (Moscow) 78(13): 1431-1446.
  5. Hyvonen, M. T., Koponen, T., Weisell, J., Pietila, M., Khomutov, A. R., Vepsalainen, J., Alhonen, L. and Keinanen, T. A. (2013). Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A. Biochem J 453(3): 467-474.
  6. Hyvonen, M. T., Weisell, J., Khomutov, A. R., Alhonen, L., Vepsalainen, J. and Keinanen, T. A. (2013). Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N(1)-acetyltransferase and thialysine acetyltransferase. Drug Metab Dispos 41(1): 30-32.
  7. Smirnova, O. A., Isaguliants, M. G., Hyvonen, M. T., Keinanen, T. A., Tunitskaya, V. L., Vepsalainen, J., Alhonen, L., Kochetkov, S. N. and Ivanov, A. V. (2012). Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells. Biochimie 94(9): 1876-1883.
  8. Hyvonen, M. T., Keinanen, T. A., Khomutov, M., Simonian, A., Vepsalainen, J., Park, J. H., Khomutov, A. R., Alhonen, L. and Park, M. H. (2012). Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A. Amino Acids 42(2-3): 685-695.
  9. Nayvelt, I., John, S., Hsu, H. C., Yang, P., Liu, W., Das, G., Hyvonen, M. T., Alhonen, L., Keinanen, T. A., Shirahata, A., Patel, R., Thomas, T. and Thomas, T. J. (2012). A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells. Amino Acids 42(2-3): 899-911.
  10. Hyvonen, M. T., Uimari, A., Vepsalainen, J., Khomutov, A. R., Keinanen, T. A. and Alhonen, L. (2012). Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase. Amino Acids 42(2-3): 485-493.
  11. Jin, H. T., Lamsa, T., Nordback, P. H., Hyvonen, M. T., Grigorenko, N., Khomutov, A. R., Nordback, I., Raty, S., Porsti, I., Alhonen, L. and Sand, J. (2011). Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine. Pharmacol Rep 63(4): 999-1008.
  12. Cerrada-Gimenez, M., Weisell, J., Hyvonen, M. T., Park, M. H., Alhonen, L., Vepsalainen, J. and Keinanen, T. A. (2011). Complex N-acetylation of triethylenetetramine. Drug Metab Dispos 39(12): 2242-2249.
  13. Hyvonen, M. T., Keinanen, T. A., Khomutov, M., Simonian, A., Weisell, J., Kochetkov, S. N., Vepsalainen, J., Alhonen, L. and Khomutov, A. R. (2011). The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism. J Med Chem 54(13): 4611-4618.
  14. Jin, H. T., Lamsa, T., Nordback, P. H., Hyvonen, M. T., Raty, S., Nordback, I., Herzig, K. H., Alhonen, L. and Sand, J. (2011). Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis. Pancreatology 11(2): 83-91.
  15. Khomutov, M. A., Khivonen, M. T., Simonian, A. R., Vepsalainen, I., Alkhonen, L., Kochetkov, S. N. and Keinanen, T. A. (2011). Novel metabolically stable functionally-active mimetic of spermidine. Bioorg Khim 37(2): 253-258.
  16. Cerrada-Gimenez, M., Pietila, M., Loimas, S., Pirinen, E., Hyvonen, M. T., Keinanen, T. A., Janne, J. and Alhonen, L. (2011). Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults. Transgenic Res 20(2): 387-396.
  17. Khomutov, A. R., Weisell, J., Khomutov, M. A., Grigorenko, N. A., Simonian, A. R., Hakkinen, M. R., Keinanen, T. A., Hyvonen, M. T., Alhonen, L., Kochetkov, S. N. and Vepsalainen, J. (2011). Methylated polyamines as research tools. Methods Mol Biol 720: 449-461. (Book chapter)
  18. Uimari, A., Hyvonen, M. T., Pirinen, E. and Alhonen, L. (2011). Transgenic rodents with altered SSAT expression as models of pancreatitis and altered glucose and lipid metabolism. Methods Mol Biol 720: 143-158. (Book chapter)
  19. Weisell, J., Hyvonen, M. T., Hakkinen, M. R., Grigorenko, N. A., Pietila, M., Lampinen, A., Kochetkov, S. N., Alhonen, L., Vepsalainen, J., Keinanen, T. A. and Khomutov, A. R. (2010). Synthesis and biological characterization of novel charge-deficient spermine analogues. J Med Chem 53(15): 5738-5748.
  20. Hyvonen, M. T., Sinervirta, R., Keinanen, T. A., Fashe, T., Grigorenko, N., Khomutov, A. R., Vepsalainen, J. and Alhonen, L. (2010). Acute pancreatitis induced by activated polyamine catabolism is associated with coagulopathy: effects of alpha-methylated polyamine analogs on hemostasis. Pancreatology 10(2-3): 208-221.
  21. Hakkinen, M. R., Hyvonen, M. T., Auriola, S., Casero, R. A., Jr., Vepsalainen, J., Khomutov, A. R., Alhonen, L. and Keinanen, T. A. (2010). Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases. Amino Acids 38(2): 369-381.
  22. Hyvonen, M. T., Sinervirta, R., Grigorenko, N., Khomutov, A. R., Vepsalainen, J., Keinanen, T. A. and Alhonen, L. (2010). alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage. Amino Acids 38(2): 575-581.
  23. Weisell, J., Hyvonen, M. T., Vepsalainen, J., Alhonen, L., Keinanen, T. A., Khomutov, A. R. and Soininen, P. (2010). Novel isosteric charge-deficient spermine analogue--1,12-diamino-3,6,9-triazadodecane: synthesis, pK(a) measurement and biological activity. Amino Acids 38(2): 501-507.
  24. Nayvelt, I., Hyvonen, M. T., Alhonen, L., Pandya, I., Thomas, T., Khomutov, A. R., Vepsalainen, J., Patel, R., Keinanen, T. A. and Thomas, T. J. (2010). DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage. Biomacromolecules 11(1): 97-105.
  25. Hyvonen, M. T., Howard, M. T., Anderson, C. B., Grigorenko, N., Khomutov, A. R., Vepsalainen, J., Alhonen, L., Janne, J. and Keinanen, T. A. (2009). Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues. Biochem J 422(2): 321-328.
  26. Alhonen, L., Uimari, A., Pietila, M., Hyvonen, M. T., Pirinen, E. and Keinanen, T. A. (2009). Transgenic animals modelling polyamine metabolism-related diseases. Essays Biochem 46: 125-144. Review.
  27. Khomutov, A. R., Keinanen, T. A., Grigorenko, N. A., Hyvonen, M. T., Uimari, A., Pietila, M., Cerrada-Gimenez, M., Simonian, A. R., Khomutov, M. A., Verspalainen, J., Alhonen, L. and Janne, J. (2009). [Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism]. Mol Biol (Mosk) 43(2): 274-285.
  28. Jin, H. T., Lamsa, T., Hyvonen, M. T., Sand, J., Raty, S., Grigorenko, N., Khomutov, A. R., Herzig, K. H., Alhonen, L. and Nordback, I. (2008). A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate. Surgery 144(1): 49-56.
  29. Jin, H. T., Lamsa, T., Merentie, M., Hyvonen, M. T., Sand, J., Raty, S., Herzig, K. H., Alhonen, L. and Nordback, I. (2008). Polyamine levels in the pancreas and the blood change according to the severity of pancreatitis. Pancreatology 8(1): 15-24.
  30. Hyvonen, M. T., Keinanen, T. A., Cerrada-Gimenez, M., Sinervirta, R., Grigorenko, N., Khomutov, A. R., Vepsalainen, J., Alhonen, L. and Janne, J. (2007). Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis. J Biol Chem 282(48): 34700-34706.
  31. Keinanen, T. A., Jarvinen, A., Uimari, A., Vepsalainen, J., Khomutov, A. R., Grigorenko, N. A., Hyvonen, M. T., Cerrada-Gimenez, M., Alhonen, L. and Janne, J. (2007). Alpha-methylated polyamines as potential drugs and experimental tools in enzymology. Mini Rev Med Chem 7(8): 813-820. (Review)
  32. Hyvonen, M. T., Merentie, M., Uimari, A., Keinanen, T. A., Janne, J. and Alhonen, L. (2007). Mechanisms of polyamine catabolism-induced acute pancreatitis. Biochem Soc Trans 35(Pt 2): 326-330.
  33. Hyvonen, M. T., Uimari, A., Keinanen, T. A., Heikkinen, S., Pellinen, R., Wahlfors, T., Korhonen, A., Narvanen, A., Wahlfors, J., Alhonen, L. and Janne, J. (2006). Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1-acetyltransferase. RNA 12(8): 1569-1582.
  34. Hyvonen, M. T., Herzig, K. H., Sinervirta, R., Albrecht, E., Nordback, I., Sand, J., Keinanen, T. A., Vepsalainen, J., Grigorenko, N., Khomutov, A. R., Kruger, B., Janne, J. and Alhonen, L. (2006). activated polyamine catabolism in acute pancreatitis: alpha-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality. Am J Pathol 168(1): 115-122.
  35. Janne, J., Alhonen, L., Pietila, M., Keinanen, T. A., Uimari, A., Hyvonen, M. T., Pirinen, E. and Jarvinen, A. (2006). Genetic manipulation of polyamine catabolism in rodents. J Biochem 139(2): 155-160. (Review)
  36. Jarvinen, A., Grigorenko, N., Khomutov, A. R., Hyvonen, M. T., Uimari, A., Vepsalainen, J., Sinervirta, R., Keinanen, T. A., Vujcic, S., Alhonen, L., Porter, C. W. and Janne, J. (2005). Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines. J Biol Chem 280(8): 6595-6601.
  37. Janne, J., Alhonen, L., Keinanen, T. A., Pietila, M., Uimari, A., Pirinen, E., Hyvonen, M. T. and Jarvinen, A. (2005). Animal disease models generated by genetic engineering of polyamine metabolism. J Cell Mol Med 9(4): 865-882. (Review)
Protocols by Mervi T. Hyvönen
  1. Assay of Ornithine Decarboxylase and Spermidine/Spermine N1-acetyltransferase Activities