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Florencio M. Ubeira

Education

Ph.D. in Microbiology, Department of Microbiology and Parasitology, University of Santiago de Compostela, Spain, 1982

Current position

Full Professor of Parasitology and Applied Immunology, Department of Microbiology and Parasitology, University of Santiago de Compostela, Spain (since 1995)

Publications (since 2009)

  1. Ubeira, F. M. (2014). Travelling with Anisakis allergens. Int Arch Allergy Immunol 163(4): 243-244.
  2. Munteanu, C. R., Pedreira, N., Dorado, J., Pazos, A., Pérez‐Montoto, L. G., Ubeira, F. M. and González‐Díaz, H. (2014). LECTINPred: web Server that Uses Complex Networks of Protein Structure for Prediction of Lectins with Potential Use as Cancer Biomarkers or in Parasite Vaccine Design. Mol Inform 33(4): 276-285.
  3. Gonzalez-Diaz, H., Perez-Montoto, L. G. and Ubeira, F. M. (2014). Model for vaccine design by prediction of B-epitopes of IEDB given perturbations in peptide sequence, in vivo process, experimental techniques, and source or host organisms. J Immunol Res 2014: 768515.
  4. Martinez-Sernandez, V., Mezo, M., Gonzalez-Warleta, M., Perteguer, M. J., Muino, L., Guitian, E., Garate, T. and Ubeira, F. M. (2014). The MF6p/FhHDM-1 major antigen secreted by the trematode parasite Fasciola hepatica is a heme-binding protein. J Biol Chem 289(3): 1441-1456.
  5. Vazquez-Prieto, S., Gonzalez-Diaz, H., Paniagua, E., Vilas, R. and Ubeira, F. M. (2014). A QSPR-like model for multilocus genotype networks of Fasciola hepatica in Northwest Spain. J Theor Biol 343: 16-24.
  6. Mladineo, I., Poljak, V., Martinez-Sernandez, V. and Ubeira, F. M. (2014). Anti-Anisakis IgE seroprevalence in the healthy Croatian coastal population and associated risk factors. PLoS Negl Trop Dis 8(2): e2673.
  7. Daschner, A., Fernandez-Figares, V., Rodero, M., Valls, A., De Frutos, C., Ubeira, F. M. and Cuellar, C. (2014). Specific IgG4: possible role in the pathogenesis and a new marker in the diagnosis of Anisakis-associated allergic disease. Scand J Immunol 79(2): 120-126.
  8. Sobarzo-Sanchez, E., Bilbao-Ramos, P., Dea-Ayuela, M., Gonzalez-Diaz, H., Yanez, M., Uriarte, E., Santana, L., Martinez-Sernandez, V., Bolas-Fernandez, F. and Ubeira, F. M. (2013). Synthetic oxoisoaporphine alkaloids: in vitro, in vivo and in silico assessment of antileishmanial activities. PLoS One 8(10): e77560.
  9. Daschner, A., Fernandez-Figares, V., Valls, A., de Frutos, C., Rodero, M., Ubeira, F. M. and Cuellar, C. (2013). Different fish-eating habits and cytokine production in chronic urticaria with and without sensitization against the fish-parasite Anisakis simplex. Allergol Int 62(2): 191-201.
  10. Cuellar, C., Daschner, A., Valls, A., De Frutos, C., Fernandez-Figares, V., Anadon, A. M., Rodriguez, E., Garate, T., Rodero, M. and Ubeira, F. M. (2012). Ani s 1 and Ani s 7 recombinant allergens are able to differentiate distinct Anisakis simplex-associated allergic clinical disorders. Arch Dermatol Res 304(4): 283-288.
  11. Gonzalez-Diaz, H., Concu, R., G Perez-Montoto, L., M Ubeira, F., Romaris, F., Paniagua, E., Duardo-Sanchez, A. and Prado-Prado, F. (2012). Generalized String Pseudo-Folding Lattices in Bioinformatics: State-of-Art Review, New Model for Enzyme Sub-Classes, and Study of ESTs on Trichinella spiralis. Curr Bioinform 7(1): 7-34.
  12. Martinez-Sernandez, V., Muino, L., Perteguer, M. J., Garate, T., Mezo, M., Gonzalez-Warleta, M., Muro, A., Correia da Costa, J. M., Romaris, F. and Ubeira, F. M. (2011). Development and evaluation of a new lateral flow immunoassay for serodiagnosis of human fasciolosis. PLoS Negl Trop Dis 5(11): e1376.
  13. Muino, L., Perteguer, M. J., Garate, T., Martinez-Sernandez, V., Beltran, A., Romaris, F., Mezo, M., Gonzalez-Warleta, M. and Ubeira, F. M. (2011). Molecular and immunological characterization of Fasciola antigens recognized by the MM3 monoclonal antibody. Mol Biochem Parasitol 179(2): 80-90.
  14. Prado-Prado, F., Garcia-Mera, X., Abeijon, P., Alonso, N., Caamano, O., Yanez, M., Garate, T., Mezo, M., Gonzalez-Warleta, M., Muino, L., Ubeira, F. M. and Gonzalez-Diaz, H. (2011). Using entropy of drug and protein graphs to predict FDA drug-target network: theoretic-experimental study of MAO inhibitors and hemoglobin peptides from Fasciola hepatica. Eur J Med Chem 46(4): 1074-1094.
  15. Mezo, M., Gonzalez-Warleta, M., Castro-Hermida, J. A., Muino, L. and Ubeira, F. M. (2011). Association between anti-F. hepatica antibody levels in milk and production losses in dairy cows. Vet Parasitol 180(3-4): 237-242.
  16. Gonzalez-Diaz, H., Prado-Prado, F., Sobarzo-Sanchez, E., Haddad, M., Maurel Chevalley, S., Valentin, A., Quetin-Leclercq, J., Dea-Ayuela, M. A., Teresa Gomez-Munos, M., Munteanu, C. R., Jose Torres-Labandeira, J., Garcia-Mera, X., Tapia, R. A. and Ubeira, F. M. (2011). NL MIND-BEST: a web server for ligands and proteins discovery--theoretic-experimental study of proteins of Giardia lamblia and new compounds active against Plasmodium falciparum. J Theor Biol 276(1): 229-249.
  17. Ubeira, F. M., Anadon, A. M., Salgado, A., Carvajal, A., Ortega, S., Aguirre, C., Lopez-Goikoetxea, M. J., Ibanez, L. and Figueiras, A. (2011). Synergism between prior Anisakis simplex infections and intake of NSAIDs, on the risk of upper digestive bleeding: a case-control study. PLoS Negl Trop Dis 5(6): e1214.
  18. Gonzalez-Diaz, H., Muino, L., Anadon, A. M., Romaris, F., Prado-Prado, F. J., Munteanu, C. R., Dorado, J., Sierra, A. P., Mezo, M., Gonzalez-Warleta, M., Garate, T. and Ubeira, F. M. (2011). MISS-Prot: web server for self/non-self discrimination of protein residue networks in parasites; theory and experiments in Fasciola peptides and Anisakis allergens. Mol Biosyst 7(6): 1938-1955.
  19. Gonzalez-Diaz, H., Prado-Prado, F., Garcia-Mera, X., Alonso, N., Abeijon, P., Caamano, O., Yanez, M., Munteanu, C. R., Pazos, A., Dea-Ayuela, M. A., Gomez-Munoz, M. T., Garijo, M. M., Sansano, J. and Ubeira, F. M. (2011). MIND-BEST: Web server for drugs and target discovery; design, synthesis, and assay of MAO-B inhibitors and theoretical-experimental study of G3PDH protein from Trichomonas gallinae. J Proteome Res 10(4): 1698-1718.   
  20. Vazquez-Prieto, S., Vilas, R., Mezo, M., Gonzalez-Warleta, M., Ubeira, F. M. and Paniagua, E. (2011). Allozyme markers suitable for population genetic analysis of Fasciola hepatica. Vet Parasitol 176(1): 84-88.
  21. Mezo, M., Gonzalez-Warleta, M., Castro-Hermida, J. A., Muino, L. and Ubeira, F. M. (2010). Field evaluation of the MM3-SERO ELISA for detection of anti-Fasciola IgG antibodies in milk samples from individual cows and bulk milk tanks. Parasitol Int 59(4): 610-615.
  22. Gonzalez-Diaz, H., Duardo-Sanchez, A., Ubeira, F. M., Prado-Prado, F., Perez-Montoto, L. G., Concu, R., Podda, G. and Shen, B. (2010). Review of MARCH-INSIDE & complex networks prediction of drugs: ADMET, anti-parasite activity, metabolizing enzymes and cardiotoxicity proteome biomarkers. Curr Drug Metab 11(4): 379-406.
  23. Gonzalez-Diaz, H., Romaris, F., Duardo-Sanchez, A., Perez-Montoto, L. G., Prado-Prado, F., Patlewicz, G. and Ubeira, F. M. (2010). Predicting drugs and proteins in parasite infections with topological indices of complex networks: theoretical backgrounds, applications, and legal issues. Curr Pharm Des 16(24): 2737-2764.
  24. Concu, R., Podda, G., Ubeira, F. M. and Gonzalez-Diaz, H. (2010). Review of QSAR models for enzyme classes of drug targets: Theoretical background and applications in parasites, hosts, and other organisms. Curr Pharm Des 16(24): 2710-2723.
  25. Anadon, A. M., Rodriguez, E., Garate, M. T., Cuellar, C., Romaris, F., Chivato, T., Rodero, M., Gonzalez-Diaz, H. and Ubeira, F. M. (2010). Diagnosing human anisakiasis: recombinant Ani s 1 and Ani s 7 allergens versus the UniCAP 100 fluorescence enzyme immunoassay. Clin Vaccine Immunol 17(4): 496-502.
  26. Mezo, M., Gonzalez-Warleta, M., Castro-Hermida, J. A., Carro, C. and Ubeira, F. M. (2010). Kinetics of anti-Fasciola IgG antibodies in serum and milk from dairy cows during lactation, and in serum from calves after feeding colostrum from infected dams. Vet Parasitol 168(1-2): 36-44.
  27. Gonzalez-Diaz, H., Dea-Ayuela, M. A., Perez-Montoto, L. G., Prado-Prado, F. J., Aguero-Chapin, G., Bolas-Fernandez, F., Vazquez-Padron, R. I. and Ubeira, F. M. (2010). QSAR for RNases and theoretic-experimental study of molecular diversity on peptide mass fingerprints of a new Leishmania infantum protein. Mol Divers 14(2): 349-369.
  28. Prado-Prado, F. J., Ubeira, F. M., Borges, F. and Gonzalez-Diaz, H. (2010). Unified QSAR & network-based computational chemistry approach to antimicrobials. II. Multiple distance and triadic census analysis of antiparasitic drugs complex networks. J Comput Chem 31(1): 164-173.
  29. Pérez-Montoto, L. G., Prado-Prado, F., Ubeira, F. M. and González-Díaz, H. (2009). Study of parasitic infections, cancer, and other diseases with mass-spectrometry and quantitative proteome-disease relationships. Curr Proteomics 6(4): 246-261.
  30. Gonzalez-Diaz, H., Perez-Montoto, L. G., Duardo-Sanchez, A., Paniagua, E., Vazquez-Prieto, S., Vilas, R., Dea-Ayuela, M. A., Bolas-Fernandez, F., Munteanu, C. R., Dorado, J., Costas, J. and Ubeira, F. M. (2009). Generalized lattice graphs for 2D-visualization of biological information. J Theor Biol 261(1): 136-147.
  31. Concu, R., Dea-Ayuela, M. A., Perez-Montoto, L. G., Prado-Prado, F. J., Uriarte, E., Bolas-Fernandez, F., Podda, G., Pazos, A., Munteanu, C. R., Ubeira, F. M. and Gonzalez-Diaz, H. (2009). 3D entropy and moments prediction of enzyme classes and experimental-theoretic study of peptide fingerprints in Leishmania parasites. Biochim Biophys Acta 1794(12): 1784-1794.
  32. Concu, R., Dea-Ayuela, M. A., Perez-Montoto, L. G., Bolas-Fernandez, F., Prado-Prado, F. J., Podda, G., Uriarte, E., Ubeira, F. M. and Gonzalez-Diaz, H. (2009). Prediction of enzyme classes from 3D structure: a general model and examples of experimental-theoretic scoring of peptide mass fingerprints of Leishmania proteins. J Proteome Res 8(9): 4372-4382.
  33. Pérez-Montoto, L. G., Dea-Ayuela, M. A., Prado-Prado, F. J., Bolas-Fernández, F., Ubeira, F. M. and González-Díaz, H. (2009). Study of peptide fingerprints of parasite proteins and drug–DNA interactions with Markov-Mean-Energy invariants of biopolymer molecular-dynamic lattice networks. Polymer 50(15): 3857-3870.
  34. Ubeira, F. M., Muino, L., Valero, M. A., Periago, M. V., Perez-Crespo, I., Mezo, M., Gonzalez-Warleta, M., Romaris, F., Paniagua, E., Cortizo, S., Llovo, J. and Mas-Coma, S. (2009). MM3-ELISA detection of Fasciola hepatica coproantigens in preserved human stool samples. Am J Trop Med Hyg 81(1): 156-162.
  35. Anadon, A. M., Romaris, F., Escalante, M., Rodriguez, E., Garate, T., Cuellar, C. and Ubeira, F. M. (2009). The Anisakis simplex Ani s 7 major allergen as an indicator of true Anisakis infections. Clin Exp Immunol 156(3): 471-478.
  36. Prado-Prado, F. J., Martinez de la Vega, O., Uriarte, E., Ubeira, F. M., Chou, K. C. and Gonzalez-Diaz, H. (2009). Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks. Bioorg Med Chem 17(2): 569-575.
  37. Perez-Bello, A., Munteanu, C. R., Ubeira, F. M., De Magalhaes, A. L., Uriarte, E. and Gonzalez-Diaz, H. (2009). Alignment-free prediction of mycobacterial DNA promoters based on pseudo-folding lattice network or star-graph topological indices. J Theor Biol 256(3): 458-466.
Protocols by Florencio M. Ubeira
  1. Competitive ELISA for Protein-lipopolysaccharide (LPS) Binding