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Clara Sciorati


Ph.D. in Experimental Pharmacotherapy, Department of Pharmacology and University of Milan and S. Raffaele Scientific Institute, Milan Italy, 1994

Current position

Researcher, Laboratory of Autoimmunity, Division of Regenerative Medicine S. Raffaele Hospital Milan, Italy

Publications (selected)

  1. Cordani, N., Pisa, V., Pozzi, L., Sciorati, C.* and Clementi, E.* (2014). Nitric oxide controls fat deposition in dystrophic skeletal muscle by regulating fibro-adipogenic precursor differentiation. Stem Cells 32(4): 874-885. (*Co-corresponding authors)
  2. Rigamonti, E., Zordan, P., Sciorati, C., Rovere-Querini, P. and Brunelli, S. (2014). Macrophage plasticity in skeletal muscle repair. Biomed Res Int 2014: 560629.
  3. Sciorati, C., Esposito, A., Campana, L., Canu, T., Monno, A., Palmisano, A., De Cobelli, F., Del Maschio, A., Ascheman, D. P., Manfredi, A. A. and Rovere-Querini, P. (2014). 7-Tesla magnetic resonance imaging precisely and noninvasively reflects inflammation and remodeling of the skeletal muscle in a mouse model of antisynthetase syndrome. Biomed Res Int 2014: 879703.
  4. Sciorati, C., Staszewsky, L., Zambelli, V., Russo, I., Salio, M., Novelli, D., Di Grigoli, G., Moresco, R. M., Clementi, E. and Latini, R. (2013). Ibuprofen plus isosorbide dinitrate treatment in the mdx mice ameliorates dystrophic heart structure. Pharmacol Res 73: 35-43.
  5. Zordan, P., Sciorati, C., Campana, L., Cottone, L., Clementi, E., Querini, P. R. and Brunelli, S. (2013). The nitric oxide-donor molsidomine modulates the innate inflammatory response in a mouse model of muscular dystrophy. Eur J Pharmacol 715(1-3): 296-303.
  6. Buono, R., Vantaggiato, C., Pisa, V., Azzoni, E., Bassi, M. T., Brunelli, S., Sciorati, C.* and Clementi, E.* (2012). Nitric oxide sustains long-term skeletal muscle regeneration by regulating fate of satellite cells via signaling pathways requiring Vangl2 and cyclic GMP. Stem Cells 30(2): 197-209. (*Co-corresponding authors)
  7. D'Angelo, M. G., Gandossini, S., Martinelli Boneschi, F., Sciorati, C., Bonato, S., Brighina, E., Comi, G. P., Turconi, A. C., Magri, F., Stefanoni, G., Brunelli, S., Bresolin, N., Cattaneo, D. and Clementi, E. (2012). Nitric oxide donor and non steroidal anti inflammatory drugs as a therapy for muscular dystrophies: evidence from a safety study with pilot efficacy measures in adult dystrophic patients. Pharmacol Res 65(4): 472-479.
  8. Sciorati, C., Miglietta, D., Buono, R., Pisa, V., Cattaneo, D., Azzoni, E., Brunelli, S. and Clementi, E. (2011). A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy. Pharmacol Res 64(3): 210-217.
  9. Sciorati, C., Buono, R., Azzoni, E., Casati, S., Ciuffreda, P., D'Angelo, G., Cattaneo, D., Brunelli, S. and Clementi, E. (2010). Co-administration of ibuprofen and nitric oxide is an effective experimental therapy for muscular dystrophy, with immediate applicability to humans. Br J Pharmacol 160(6): 1550-1560.
  10. Sciorati, C., Touvier, T., Buono, R., Pessina, P., Francois, S., Perrotta, C., Meneveri, R., Clementi, E. and Brunelli, S. (2009). Necdin is expressed in cachectic skeletal muscle to protect fibers from tumor-induced wasting. J Cell Sci 122(Pt 8): 1119-1125.
  11. Brunelli, S., Rovere-Querini, P., Sciorati, C., Manfredi, A. A. and Clementi, E. (2007). Nitric oxide: emerging concepts about its use in cell-based therapies. Expert Opin Investig Drugs 16(1): 33-43.
  12. Brunelli, S.*, Sciorati, C.*, D'Antona, G., Innocenzi, A., Covarello, D., Galvez, B. G., Perrotta, C., Monopoli, A., Sanvito, F., Bottinelli, R., Ongini, E., Cossu, G. and Clementi, E. (2007). Nitric oxide release combined with nonsteroidal antiinflammatory activity prevents muscular dystrophy pathology and enhances stem cell therapy. Proc Natl Acad Sci U S A 104(1): 264-269. (*Co-authors)
  13. Sciorati, C., Galvez, B. G., Brunelli, S., Tagliafico, E., Ferrari, S., Cossu, G. and Clementi, E. (2006). Ex vivo treatment with nitric oxide increases mesoangioblast therapeutic efficacy in muscular dystrophy. J Cell Sci 119(Pt 24): 5114-5123.   
  14. Perrotta, C., Falcone, S., Capobianco, A., Camporeale, A., Sciorati, C., De Palma, C., Pisconti, A., Rovere-Querini, P., Bellone, M., Manfredi, A. A. and Clementi, E. (2004). Nitric oxide confers therapeutic activity to dendritic cells in a mouse model of melanoma. Cancer Res 64(11): 3767-3771.
  15. Falcone, S., Perrotta, C., De Palma, C., Pisconti, A., Sciorati, C., Capobianco, A., Rovere-Querini, P., Manfredi, A. A. and Clementi, E. (2004). Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cells. J Immunol 173(7): 4452-4463.   
  16. Nisoli, E., Clementi, E., Paolucci, C., Cozzi, V., Tonello, C., Sciorati, C., Bracale, R., Valerio, A., Francolini, M., Moncada, S. and Carruba, M. O. (2003). Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 299(5608): 896-899.
  17. Ferrarini, M., Consogno, G., Rovere, P., Sciorati, C., Dagna, L., Resta, D., Rugarli, C. and Manfredi, A. A. (2001). Inhibition of caspases maintains the antineoplastic function of gammadelta T cells repeatedly challenged with lymphoma cells. Cancer Res 61(7): 3092-3095.
  18. Rabuffetti, M.*, Sciorati, C.*, Tarozzo, G., Clementi, E., Manfredi, A. A. and Beltramo, M. (2000). Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines. J Neurosci 20(12): 4398-4404. (*Co-authors)
  19. Ferrarini, M., Imro, M. A., Sciorati, C., Heltai, S., Protti, M. P., Pellicciari, C., Rovere, P., Manfredi, A. A. and Rugarli, C. (1999). Blockade of the Fas-triggered intracellular signaling pathway in human melanomas is circumvented by cytotoxic lymphocytes. Int J Cancer 81(4): 573-579.
  20. Lievremont, J. P., Sciorati, C., Morandi, E., Paolucci, C., Bunone, G., Della Valle, G., Meldolesi, J. and Clementi, E. (1999). The p75(NTR)-induced apoptotic program develops through a ceramide-caspase pathway negatively regulated by nitric oxide. J Biol Chem 274(22): 15466-15472.
  21. Sciorati, C., Rovere, P., Ferrarini, M., Paolucci, C., Heltai, S., Vaiani, R., Clementi, E. and Manfredi, A. A. (1999). Generation of nitric oxide by the inducible nitric oxide synthase protects gamma delta T cells from Mycobacterium tuberculosis-induced apoptosis. J Immunol 163(3): 1570-1576.
  22. Manfredi, A. A., Heltai, S., Rovere, P., Sciorati, C., Paolucci, C., Galati, G., Rugarli, C., Vaiani, R., Clementi, E. and Ferrarini, M. (1998). Mycobacterium tuberculosis exploits the CD95/CD95 ligand system of gammadelta T cells to cause apoptosis. Eur J Immunol 28(6): 1798-1806.
  23. Sciorati, C., Nistico, G., Meldolesi, J. and Clementi, E. (1997). Nitric oxide effects on cell growth: GMP-dependent stimulation of the AP-1 transcription complex and cyclic GMP-independent slowing of cell cycling. Br J Pharmacol 122(4): 687-697.
  24. Sciorati, C., Rovere, P., Ferrarini, M., Heltai, S., Manfredi, A. A. and Clementi, E. (1997). Autocrine nitric oxide modulates CD95-induced apoptosis in gammadelta T lymphocytes. J Biol Chem 272(37): 23211-23215.
  25. Rovere, P., Clementi, E., Ferrarini, M., Heltai, S., Sciorati, C., Sabbadini, M. G., Rugarli, C. and Manfredi, A. A. (1996). CD95 engagement releases calcium from intracellular stores of long term activated, apoptosis-prone gammadelta T cells. J Immunol 156(12): 4631-4637.
Protocols by Clara Sciorati
  1. Isolation of FAP Cells from Mouse Dystrophic Skeletal Muscle Using Fluorescence Activated Cell Sorting