Welcome guest, Login | Register


Carmen Valente


Ph.D. in Life Sciences, Open University, UK
Sponsoring establishments: “Mario Negri Sud" Institute and Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy, 2011

Current position

Researcher, Institute of Protein Biochemistry, National Research Council, Naples, Italy


  1. Valente, C., Luini, A. and Corda, D. (2013). Components of the CtBP1/BARS-dependent fission machinery. Histochem Cell Biol 140(4): 407-421.
  2. Colanzi, A., Grimaldi, G., Catara, G., Valente, C., Cericola, C., Liberali, P., Ronci, M., Lalioti, V. S., Bruno, A., Beccari, A. R., Urbani, A., De Flora, A., Nardini, M., Bolognesi, M., Luini, A. and Corda, D. (2013). Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS. Proc Natl Acad Sci U S A 110(24): 9794-9799.
  3. D'Apice, L., Costa, V., Valente, C., Trovato, M., Pagani, A., Manera, S., Regolo, L., Zambelli, A., Ciccodicola, A. and De Berardinis, P. (2013). Analysis of SEMA6B gene expression in breast cancer: identification of a new isoform. Biochim Biophys Acta 1830(10): 4543-4553.
  4. Valente, C., Turacchio, G., Mariggio, S., Pagliuso, A., Gaibisso, R., Di Tullio, G., Santoro, M., Formiggini, F., Spano, S., Piccini, D., Polishchuk, R. S., Colanzi, A., Luini, A. and Corda, D. (2012). A 14-3-3gamma dimer-based scaffold bridges CtBP1-S/BARS to PI(4)KIIIbeta to regulate post-Golgi carrier formation. Nat Cell Biol 14(4): 343-354.
    *Classified by the Faculty of 1000 in the top 2% of papers published in 2012 in medicine and biology
    *Classified by the Italian Association for Cancer research (AIRC) as one of the top 10 papers published from projects financed by AIRC in 2012
    *Classified by the Italian National Research Council as one of the published highlights of 2011/2012
  5. Yang, J. S., Valente, C., Polishchuk, R. S., Turacchio, G., Layre, E., Moody, D. B., Leslie, C. C., Gelb, M. H., Brown, W. J., Corda, D., Luini, A. and Hsu, V. W. (2011). COPI acts in both vesicular and tubular transport. Nat Cell Biol 13(8): 996-1003.
    *Classified by the Italian National Research Council as one of the published highlights of 2010/2011
  6. Valente, C., Polishchuk, R. and De Matteis, M. A. (2010). Rab6 and myosin II at the cutting edge of membrane fission. Nat Cell Biol 12(7): 635-638.
  7. Nardini, M., Valente, C., Ricagno, S., Luini, A., Corda, D. and Bolognesi, M. (2009). CtBP1/BARS Gly172-->Glu mutant structure: impairing NAD(H)-binding and dimerization. Biochem Biophys Res Commun 381(1): 70-74.
  8. Yang, J. S., Gad, H., Lee, S. Y., Mironov, A., Zhang, L., Beznoussenko, G. V., Valente, C., Turacchio, G., Bonsra, A. N., Du, G., Baldanzi, G., Graziani, A., Bourgoin, S., Frohman, M. A., Luini, A. and Hsu, V. W. (2008). A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance. Nat Cell Biol 10(10): 1146-1153.
  9. Liberali, P., Kakkonen, E., Turacchio, G., Valente, C., Spaar, A., Perinetti, G., Bockmann, R. A., Corda, D., Colanzi, A., Marjomaki, V. and Luini, A. (2008). The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS. EMBO J 27(7): 970-981.
  10. Valente, C., Spano, S., Luini, A. and Corda, D. (2005). Purification and functional properties of the membrane fissioning protein CtBP3/BARS. Methods Enzymol 404: 296-316.
  11. Bonazzi, M., Spano, S., Turacchio, G., Cericola, C., Valente, C., Colanzi, A., Kweon, H. S., Hsu, V. W., Polishchuck, E. V., Polishchuck, R. S., Sallese, M., Pulvirenti, T., Corda, D. and Luini, A. (2005). CtBP3/BARS drives membrane fission in dynamin-independent transport pathways. Nat Cell Biol 7(6): 570-580.
  12. Spano, S., Silletta, M. G., Colanzi, A., Alberti, S., Fiucci, G., Valente, C., Fusella, A., Salmona, M., Mironov, A., Luini, A. and Corda, D. (1999). Molecular cloning and functional characterization of brefeldin A-ADP-ribosylated substrate. A novel protein involved in the maintenance of the Golgi structure. J Biol Chem 274(25): 17705-17710.
Protocols by Carmen Valente
  1. Preparation of Golgi Membranes from Rat Liver