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Yong-Xiang Wang

Education

Ph.D. in Pharmacology, The University of British Columbia, Vancouver, B. C., Canada, 1994

Current position

Professor of Pharmacology and Biotechnology, King’s Lab, School of Pharmacy, Shanghai Jiao Tong University (2003-present)

Publications (since 2005)

  1. Fan, H., Gong, N., Li, T. F., Ma, A. N., Wu, X. Y., Wang, M. W. and Wang, Y. X. (2014). Nonpeptidic GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating beta-endorphin release from spinal microglia. Br J Pharmacol. (Epub ahead of print)
  2. Xie, D., Wang, Y., Xie, J., Lu, J., Cui, J., Zhang, M., Fu, L. and Wang, Y. (2014). Quinoxaline-2, 3-diones: potential d-amino acid oxidase (DAAO) inhibitors. Med Chem Res 23(11): 4977-4989.
  3. Zhu, B., Gong, N., Fan, H., Peng, C. S., Ding, X. J., Jiang, Y. and Wang, Y. X. (2014). Lamiophlomis rotata, an Orally Available Tibetan Herbal Painkiller, Specifically Reduces Pain Hypersensitivity States through the Activation of Spinal Glucagon-like Peptide-1 Receptors. Anesthesiology 121(4): 835-851.
  4. Ma, A. N., Wang, H., Guo, R., Wang, Y. X., Li, W., Cui, J., Wang, G., Hoffman, A. R. and Hu, J. F. (2014). Targeted gene suppression by inducing de novo DNA methylation in the gene promoter. Epigenetics Chromatin 7: 20.
  5. Gong, N., Fan, H., Ma, A. N., Xiao, Q. and Wang, Y. X. (2014). Geniposide and its iridoid analogs exhibit antinociception by acting at the spinal GLP-1 receptors. Neuropharmacology 84: 31-45.
  6. Gong, N., Xiao, Q., Zhu, B., Zhang, C. Y., Wang, Y. C., Fan, H., Ma, A. N. and Wang, Y. X. (2014). Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity. J Neurosci 34(15): 5322-5334.
  7. Gong, N., Li, X. Y., Xiao, Q. and Wang, Y. X. (2014). Identification of a novel spinal dorsal horn astroglial D-amino acid oxidase-hydrogen peroxide pathway involved in morphine antinociceptive tolerance. Anesthesiology 120(4): 962-975.
  8. Wang, Y. C., Lu, J. M., Jin, H. Z., Ma, A. N., Zhang, J. Y., Gong, N., Xiao, Q., Zhu, B., Lv, Y. F., Yu, N., Zhang, W. D. and Wang, Y. X. (2014). Beneficial effects of natural Jeju groundwaters on lipid metabolism in high-fat diet-induced hyperlipidemic rats. Nutr Res Pract 8(2): 165-171.
  9. Zhang, J. Y., Gong, N., Huang, J. L., Guo, L. C. and Wang, Y. X. (2013). Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific antinociception in chronic pain by acting at spinal alpha3 glycine receptors. Pain 154(11): 2452-2462.
  10. Wei, H., Gong, N., Huang, J. L., Fan, H., Ma, A. N., Li, X. Y., Wang, Y. X. and Pertovaara, A. (2013). Spinal D-amino acid oxidase contributes to mechanical pain hypersensitivity induced by sleep deprivation in the rat. Pharmacol Biochem Behav 111: 30-36.
  11. Ma, A. N., Gong, N., Lu, J. M., Huang, J. L., Hao, B., Guo, Y., Zhong, J., Xu, Y., Chang, J. and Wang, Y. X. (2013). Local protective effects of oral 45S5 bioactive glass on gastric ulcers in experimental animals. J Mater Sci Mater Med 24(3): 803-809.
  12. Huang, J. L., Chen, X. L., Guo, C. and Wang, Y. X. (2012). Contributions of spinal D-amino acid oxidase to bone cancer pain. Amino Acids 43(5): 1905-1918.
  13. Gong, N., Wang, Y. C., Wang, H. L., Ma, A. N., Hashimoto, K. and Wang, Y. X. (2012). Interactions of the potent D-amino acid oxidase inhibitor CBIO with morphine in pain and tolerance to analgesia. Neuropharmacology 63(3): 460-468.
  14. Chen, X. L., Li, X. Y., Qian, S. B., Wang, Y. C., Zhang, P. Z., Zhou, X. J. and Wang, Y. X. (2012). Down-regulation of spinal D-amino acid oxidase expression blocks formalin-induced tonic pain. Biochem Biophys Res Commun 421(3): 501-507.
  15. Gong, X. W., Xu, Y. H., Chen, X. L. and Wang, Y. X. (2012). Loperamide, an antidiarrhea drug, has antitumor activity by inducing cell apoptosis. Pharmacol Res 65(3): 372-378.
  16. Wang, Y. X., Gong, N., Xin, Y. F., Hao, B., Zhou, X. J. and Pang, C. C. (2012). Biological implications of oxidation and unidirectional chiral inversion of D-amino acids. Curr Drug Metab 13(3): 321-331.
  17. Lu, J. M., Gong, N., Wang, Y. C. and Wang, Y. X. (2012). D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain. Br J Pharmacol 165(6): 1941-1955.
  18. Wei, H., Huang, J.-L., Hao, B., Wang, Y.-C., Nian, G., Ma, A.-N., Li, X.-Y., Wang, Y.-X. and Pertovaara, A. (2011). Intrathecal administration of antioxidants attenuates mechanical pain hypersensitivity induced by REM sleep deprivation in the rat. Scandinavian Journal of Pain 2(2): 64-69.
  19. Gong, N., Ma, A. N., Zhang, L. J., Luo, X. S., Zhang, Y. H., Xu, M. and Wang, Y. X. (2011). Site-specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity. Br J Pharmacol 163(2): 399-412.
  20. Hao, B., Chen, Z. W., Zhou, X. J., Zimin, P. I., Miljanich, G. P., Wulff, H. and Wang, Y. X. (2011). Identification of phase-I metabolites and chronic toxicity study of the Kv1.3 blocker PAP-1 (5-(4-phenoxybutoxy)psoralen) in the rat. Xenobiotica 41(3): 198-211.
  21. Wei, H., Koivisto, A., Saarnilehto, M., Chapman, H., Kuokkanen, K., Hao, B., Huang, J. L., Wang, Y. X. and Pertovaara, A. (2011). Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat. Pain 152(3): 582-591.
  22. Zhang, W., Welihinda, A., Mechanic, J., Ding, H., Zhu, L., Lu, Y., Deng, Z., Sheng, Z., Lv, B., Chen, Y., Roberge, J. Y., Seed, B. and Wang, Y. X. (2011). EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. Pharmacol Res 63(4): 284-293.
  23. Ma, A. N., Lu, J., Zhou, X. J. and Wang, Y. X. (2011). Histone deacetylation directs DNA methylation in survivin gene silencing. Biochem Biophys Res Commun 404(1): 268-272.
  24. Gong, N., Gao, Z. Y., Wang, Y. C., Li, X. Y., Huang, J. L., Hashimoto, K. and Wang, Y. X. (2011). A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats. J Pharmacol Exp Ther 336(1): 282-293.
  25. Wei, H., Hao, B., Huang, J. L., Ma, A. N., Li, X. Y., Wang, Y. X. and Pertovaara, A. (2010). Intrathecal administration of a gap junction decoupler, an inhibitor of Na(+)-K(+)-2Cl(-) cotransporter 1, or a GABA(A) receptor agonist attenuates mechanical pain hypersensitivity induced by REM sleep deprivation in the rat. Pharmacol Biochem Behav 97(2): 377-383.
  26. Xin, Y. F., Li, X., Hao, B., Gong, N., Sun, W. Q., Konno, R. and Wang, Y. X. (2010). Indispensable but insufficient role of renal D-amino acid oxidase in chiral inversion of NG-nitro-D-arginine. Chem Biodivers 7(6): 1413-1423.
  27. Ma, A. N., Huang, W. L., Wu, Z. N., Hu, J. F., Li, T., Zhou, X. J. and Wang, Y. X. (2010). Induced epigenetic modifications of the promoter chromatin silence survivin and inhibit tumor growth. Biochem Biophys Res Commun 393(4): 592-597.
  28. Zhao, W. J., Gao, Z. Y., Wei, H., Nie, H. Z., Zhao, Q., Zhou, X. J. and Wang, Y. X. (2010). Spinal D-amino acid oxidase contributes to neuropathic pain in rats. J Pharmacol Exp Ther 332(1): 248-254.
  29. Wei, H., Ma, A., Wang, Y. X. and Pertovaara, A. (2008). Role of spinal 5-HT receptors in cutaneous hypersensitivity induced by REM sleep deprivation. Pharmacol Res 57(6): 469-475.
  30. Zhao, W., Konno, R., Zhou, X. J., Yin, M. and Wang, Y. X. (2008). Inhibition of D-amino-Acid oxidase activity induces pain relief in mice. Cell Mol Neurobiol 28(4): 581-591.
  31. Wang, X., Zhang, W., Fan, L. Y., Hao, B., Ma, A. N., Cao, C. X. and Wang, Y. X. (2007). Sensitive quantitative determination of oxymatrine and matrine in rat plasma by capillary electrophoresis with stacking induced by moving reaction boundary. Anal Chim Acta 594(2): 290-296.
  32. Wei, H., Zhao, W., Wang, Y. X. and Pertovaara, A. (2007). Pain-related behavior following REM sleep deprivation in the rat: influence of peripheral nerve injury, spinal glutamatergic receptors and nitric oxide. Brain Res 1148: 105-112.
  33. Yan-Fei, X., Xiang-Jun, Z., Jie, L. and Yong-Xiang, W. (2007). Inhibitory effects of benzoate on chiral inversion and clearance of NG-nitro-arginine in conscious rats. Drug Metabolism and Disposition 35(3): 331-334.
  34. Wu, M., Zhou, X. J., Konno, R. and Wang, Y. X. (2006). D-dopa is unidirectionally converted to L-dopa by D-amino acid oxidase, followed by dopa transaminase. Clin Exp Pharmacol Physiol 33(11): 1042-1046.
  35. Xin, Y. F., Zhou, X. J., Cheng, X. and Wang, Y. X. (2005). Renal D-amino acid oxidase mediates chiral inversion of N(G)-nitro-D-arginine. J Pharmacol Exp Ther 312(3): 1090-1096.
Protocols by Yong-Xiang Wang
  1. Pain Assessment Using the Rat and Mouse Formalin Tests