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Luciene Covolan


Ph.D. in Neurophysiology, Department of Physiology, Universidade Federal de São Paulo, 1999

Current position

Full professor of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil

Publications (since 2008)

  1. Covolan, L., de Almeida, A. C., Amorim, B., Cavarsan, C., Miranda, M. F., Aarao, M. C., Madureira, A. P., Rodrigues, A. M., Nobrega, J. N., Mello, L. E. and Hamani, C. (2014). Effects of anterior thalamic nucleus deep brain stimulation in chronic epileptic rats. PLoS One 9(6): e97618.
  2. Romariz, S. A., Garcia Kde, O., Paiva Dde, S., Bittencourt, S., Covolan, L., Mello, L. E. and Longo, B. M. (2014). Participation of bone marrow-derived cells in hippocampal vascularization after status epilepticus. Seizure 23(5): 386-389.
  3. Malheiros, J. M., Persike, D. S., Castro, L. U., Sanches, T. R., Andrade Lda, C., Tannus, A. and Covolan, L. (2014). Reduced hippocampal manganese-enhanced MRI (MEMRI) signal during pilocarpine-induced status epilepticus: edema or apoptosis? Epilepsy Res 108(4): 644-652.
  4. Cinini, S. M., Barnabe, G. F., Galvao-Coelho, N., de Medeiros, M. A., Perez-Mendes, P., Sousa, M. B., Covolan, L. and Mello, L. E. (2014). Social isolation disrupts hippocampal neurogenesis in young non-human primates. Front Neurosci 8: 45.
  5. Polli, R. S., Malheiros, J. M., Dos Santos, R., Hamani, C., Longo, B. M., Tannus, A., Mello, L. E. and Covolan, L. (2014). Changes in Hippocampal Volume are Correlated with Cell Loss but Not with Seizure Frequency in Two Chronic Models of Temporal Lobe Epilepsy. Front Neurol 5: 111.
  6. Tamura, B., Almeida, D. C., Felizardo, R., Olanda, G., Bocca, L., Pinhal, N., Moraes, B. A., Covolan, L., Câmara, N. O. and Longo, B. M. (2014). Convulsive seizure protection after hippocampal transplantation of mesenchymal cells from adipose tissue in mice. Journal of Stem Cell Reserach and Therapy 4, 196.
  7. Lima, M., Malheiros, J., Negrigo, A., Tescarollo, F., Medeiros, M., Suchecki, D., Tannus, A., Guinsburg, R. and Covolan, L. (2014). Sex-related long-term behavioral and hippocampal cellular alterations after nociceptive stimulation throughout postnatal development in rats. Neuropharmacology 77: 268-276.
  8. Hamani, C., Amorim, B. O., Wheeler, A. L., Diwan, M., Driesslein, K., Covolan, L., Butson, C. R. and Nobrega, J. N. (2014). Deep brain stimulation in rats: Different targets induce similar antidepressant-like effects but influence different circuits. Neurobiol Dis 71: 205-214.
  9. Tescarollo, F., Covolan, L. and Pellerin, L. (2014). Glutamate reduces glucose utilization while concomitantly enhancing AQP9 and MCT2 expression in cultured rat hippocampal neurons. Front Neurosci 8: 246.
  10. Malheiros, J. M., Guinsburg, R. and Covolan, L. (2014). Cortical modulation of pain: comments on "exacerbation of tonic but not phasic pain by entorhinal cortex lesions". Neurosci Lett 581: 135-136.
  11. Malheiros, J. M., Lima, M., Avanzi, R. D., Gomes da Silva, S., Suchecki, D., Guinsburg, R. and Covolan, L. (2014). Repetitive noxious neonatal stimuli increases dentate gyrus cell proliferation and hippocampal brain-derived neurotrophic factor levels. Hippocampus 24(4): 415-423.
  12. Cavarsan, C. F., Queiroz, C. M., Dos Santos, J. G., Jr., Xavier, G. F., Mello, L. E. and Covolan, L. (2013). Reduced hippocampal dentate cell proliferation and impaired spatial memory performance in aged-epileptic rats. Front Neurol 4: 106.
  13. Malheiros, J. M., Polli, R. S., Paiva, F. F., Longo, B. M., Mello, L. E., Silva, A. C., Tannus, A. and Covolan, L. (2012). Manganese-enhanced magnetic resonance imaging detects mossy fiber sprouting in the pilocarpine model of epilepsy. Epilepsia 53(7): 1225-1232.
  14. Malheiros, J. M., Longo, B. M., Tannus, A. and Covolan, L. (2012). Manganese-enhanced magnetic resonance imaging in the acute phase of the pilocarpine-induced model of epilepsy. Einstein (Sao Paulo) 10(2): 247-252.
  15. Hamani, C., Machado, D. C., Hipolide, D. C., Dubiela, F. P., Suchecki, D., Macedo, C. E., Tescarollo, F., Martins, U., Covolan, L. and Nobrega, J. N. (2012). Deep brain stimulation reverses anhedonic-like behavior in a chronic model of depression: role of serotonin and brain derived neurotrophic factor. Biol Psychiatry 71(1): 30-35.
  16. Leslie, A. T., Akers, K. G., Martinez-Canabal, A., Mello, L. E., Covolan, L. and Guinsburg, R. (2011). Neonatal inflammatory pain increases hippocampal neurogenesis in rat pups. Neurosci Lett 501(2): 78-82.
  17. Negrigo, A., Medeiros, M., Guinsburg, R. and Covolan, L. (2011). Long-term gender behavioral vulnerability after nociceptive neonatal formalin stimulation in rats. Neurosci Lett 490(3): 196-199.
  18. Perez-Mendes, P., Blanco, M. M., Calcagnotto, M. E., Cinini, S. M., Bachiega, J., Papoti, D., Covolan, L., Tannus, A. and Mello, L. E. (2011). Modeling epileptogenesis and temporal lobe epilepsy in a non-human primate. Epilepsy Res 96(1-2): 45-57.
  19. Cavarsan, C. F., Avanzi, R. D., Queiroz, C. M., Xavier, G. F., Mello, L. E. and Covolan, L. (2011). m1 Acetylcholine Receptor Expression is Decreased in Hippocampal CA1 region of Aged Epileptic Animals. Aging Dis 2(4): 301-307.
  20. Bittencourt, S., Dubiela, F. P., Queiroz, C., Covolan, L., Andrade, D., Lozano, A., Mello, L. E. and Hamani, C. (2010). Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus. Seizure 19(4): 242-246.
  21. Avanzi, R. D., Cavarsan, C. F., Santos, J. G., Jr., Hamani, C., Mello, L. E. and Covolan, L. (2010). Basal dendrites are present in newly born dentate granule cells of young but not aged pilocarpine-treated chronic epileptic rats. Neuroscience 170(3): 687-691.
  22. Hamani, C., Dubiela, F. P., Soares, J. C., Shin, D., Bittencourt, S., Covolan, L., Carlen, P. L., Laxton, A. W., Hodaie, M., Stone, S. S., Ha, Y., Hutchison, W. D., Lozano, A. M., Mello, L. E. and Oliveira, M. G. (2010). Anterior thalamus deep brain stimulation at high current impairs memory in rats. Exp Neurol 225(1): 154-162.
  23. Pascoala, V., Marchesinia, R., Matosa, A., Contea, F., Pereirab, T., Giliolic, R., Malheirosd, J., Pollid, R., Buzzád, H. and Tannúsd, A. (2010). A Interleucina 1-beta Mostra uma Ação Protetora na Fase Aguda do Modelo de Epilepsia Induzido pela Pilocarpina. J Epilepsy 16(3): 97-99.
  24. Hamani, C., Ewerton, F. I., Marcolin de Almeida, F., Bonilha, S. M., Covolan, L., Fantin Cavarsan, C., Ballester, G., Mello, L. E. and Lozano, A. M. (2009). Bilateral anterior thalamic nucleus lesions are not protective against seizures in chronic pilocarpine epileptic rats. Stereotact Funct Neurosurg 87(3): 143-147.
  25. Leslie, A. T., Guinsburg, R., Mello, L. E. and Covolan, L. (2008). Repetitive nociceptive stimuli in newborn rats do not alter the hippocampal neurogenesis. Pediatr Res 63(2): 154-157.
  26. Bachiega, J. C., Blanco, M. M., Perez-Mendes, P., Cinini, S. M., Covolan, L. and Mello, L. E. (2008). Behavioral characterization of pentylenetetrazol-induced seizures in the marmoset. Epilepsy Behav 13(1): 70-76.
  27. Borin, A., Covolan, L., Mello, L. E., Okada, D. M., Cruz, O. L. and Testa, J. R. (2008). Anatomical study of a temporal bone from a non-human primate (Callithrix sp). Braz J Otorhinolaryngol 74(3): 370-373.
Protocols by Luciene Covolan
  1. An Experimental Model of Neonatal Nociceptive Stimulation in Rats