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Lucia Lopalco

Education

Ph.D. in Immunology and Microbiology, University of Pavia, Pavia, Italy, 1985

Current position

Group Leader, Immunobiology of HIV unit

Publications (since 2005)

  1. Pastori, C., Diomede, L., Venuti, A., Fisher, G., Jarvik, J., Bomsel, M., Sanvito, F. and Lopalco, L. (2014). Induction of HIV-blocking anti-CCR5 IgA in Peyers's patches without histopathological alterations. J Virol 88(7): 3623-3635.
  2. Amu, S., Lavy-Shahaf, G., Cagigi, A., Hejdeman, B., Nozza, S., Lopalco, L., Mehr, R. and Chiodi, F. (2014). Frequency and phenotype of B cell subpopulations in young and aged HIV-1 infected patients receiving ART. Retrovirology 11(1): 76.
  3. Venuti A and Lopalco L (2014). Tackling HIV:Genetic vs Immune CCR5 targeting. J AIDS Clin Res 2014, 5:1000344.
  4. Leroux-Roels, G., Maes, C., Clement, F., van Engelenburg, F., van den Dobbelsteen, M., Adler, M., Amacker, M., Lopalco, L., Bomsel, M., Chalifour, A. and Fleury, S. (2013). Randomized Phase I: Safety, Immunogenicity and Mucosal Antiviral Activity in Young Healthy Women Vaccinated with HIV-1 Gp41 P1 Peptide on Virosomes. PLoS One 8(2): e55438.
  5. Brombin, C., Diomede, L., Tudor, D., Drillet, A. S., Pastori, C., Poli, E., Riva, A., Uberti-Foppa, C., Galli, M., Di Serio, C., Bomsel, M. and Lopalco, L. (2013). A nonparametric procedure for defining a new humoral immunologic profile in a pilot study on HIV infected patients. PLoS One 8(3): e58768.
  6. Shytaj, I. L., Chirullo, B., Wagner, W., Ferrari, M. G., Sgarbanti, R., Corte, A. D., LaBranche, C., Lopalco, L., Palamara, A. T., Montefiori, D., Lewis, M. G., Garaci, E. and Savarino, A. (2013). Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS. Retrovirology 10: 71.
  7. Ganor, Y., Drillet-Dangeard, A. S., Lopalco, L., Tudor, D., Tambussi, G., Delongchamps, N. B., Zerbib, M. and Bomsel, M. (2013). Calcitonin gene-related peptide inhibits Langerhans cell-mediated HIV-1 transmission. J Exp Med 210(11): 2161-2170.
  8. Bignami, F., Pilotti, E., Bertoncelli, L., Ronzi, P., Gulli, M., Marmiroli, N., Magnani, G., Pinti, M., Lopalco, L., Mussini, C., Ruotolo, R., Galli, M., Cossarizza, A. and Casoli, C. (2012). Stable changes in CD4+ T lymphocyte miRNA expression after exposure to HIV-1. Blood 119(26): 6259-6267.
  9. Diomede, L., Nyoka, S., Pastori, C., Scotti, L., Zambon, A., Sherman, G., Gray, C. M., Sarzotti-Kelsoe, M. and Lopalco, L. (2012). Passively transmitted gp41 antibodies in babies born from HIV-1 subtype C-seropositive women: correlation between fine specificity and protection. J Virol 86(8): 4129-4138.
  10. Pastori, C., Tudor, D., Diomede, L., Drillet, A. S., Jegerlehner, A., Rohn, T. A., Bomsel, M. and Lopalco, L. (2012). Virus like particle based strategy to elicit HIV-protective antibodies to the alpha-helic regions of gp41. Virology 431(1-2): 1-11.
  11. Tudor, D., Yu, H., Maupetit, J., Drillet, A. S., Bouceba, T., Schwartz-Cornil, I., Lopalco, L., Tuffery, P. and Bomsel, M. (2012). Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody. Proc Natl Acad Sci U S A 109(31): 12680-12685.
  12. Mestecky, J., Wright, P. F., Lopalco, L., Staats, H. F., Kozlowski, P. A., Moldoveanu, Z., Alexander, R. C., Kulhavy, R., Pastori, C., Maboko, L., Riedner, G., Zhu, Y., Wrinn, T. and Hoelscher, M. (2011). Scarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative women. AIDS Res Hum Retroviruses 27(5): 469-486.
  13. Bomsel, M., Tudor, D., Drillet, A. S., Alfsen, A., Ganor, Y., Roger, M. G., Mouz, N., Amacker, M., Chalifour, A., Diomede, L., Devillier, G., Cong, Z., Wei, Q., Gao, H., Qin, C., Yang, G. B., Zurbriggen, R., Lopalco, L. and Fleury, S. (2011). Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges. Immunity 34(2): 269-280.
  14. Legnani, L., Colombo, D., Cocchi, E., Solano, L., Villa, S., Lopalco, L., Asti, V., Diomede, L., Marinone Albini, F. and Toma, L. (2011). Modeling and Spectroscopic Studies of Synthetic Diazabicyclo Analogs of the HIV‐1 Inhibitor BMS‐378806 and Evaluation of Their Antiviral Activity. European journal of organic chemistry 2011(2): 287-294.
  15. Visciano, M. L., Diomede, L., Tagliamonte, M., Tornesello, M. L., Asti, V., Bomsel, M., Buonaguro, F. M., Lopalco, L. and Buonaguro, L. (2011). Generation of HIV-1 Virus-Like Particles expressing different HIV-1 glycoproteins. Vaccine 29(31): 4903-4912.
  16. Burastero, S. E., Frigerio, B., Lopalco, L., Sironi, F., Breda, D., Longhi, R., Scarlatti, G., Canevari, S., Figini, M. and Lusso, P. (2011). Broad-spectrum inhibition of HIV-1 by a monoclonal antibody directed against a gp120-induced epitope of CD4. PLoS One 6(7): e22081.
  17. Hasselrot, K., Bratt, G., Hirbod, T., Saberg, P., Ehnlund, M., Lopalco, L., Sandstrom, E. and Broliden, K. (2010). Orally exposed uninfected individuals have systemic anti-HIV responses associating with partners' viral load. AIDS 24(1): 35-43.
  18. Baroni, M., Matucci, A., Scarlatti, G., Soprana, E., Rossolillo, P., Lopalco, L., Zipeto, D., Siccardi, A. G. and De Santis, C. (2010). HLA-C is necessary for optimal human immunodeficiency virus type 1 infection of human peripheral blood CD4 lymphocytes. Journal of general virology 91(1): 235-241.
  19. Lopalco, L. (2010). CCR5: From Natural Resistance to a New Anti-HIV Strategy. Viruses 2(2): 574-600.
  20. Thang, P. H., Ruffin, N., Brodin, D., Rethi, B., Cam, P. D., Hien, N. T., Lopalco, L., Vivar, N. and Chiodi, F. (2010). The role of IL-1beta in reduced IL-7 production by stromal and epithelial cells: a model for impaired T-cell numbers in the gut during HIV-1 infection. J Intern Med 268(2): 181-193.
  21. Donadoni, C., Bisighini, C., Scotti, L., Diomede, L., Ngyen, M., Nouhin, J., DeSantis, L., Zambon, A., Ferrari, D., Gallotta, G., Corrao, G., Pancino, G. and Lopalco, L. (2010). Setting of methods for analysis of mucosal antibodies in seminal and vaginal fluids of HIV seropositive subjects from Cambodian and Italian cohorts. PLoS One 5(3): e9920.
  22. Burastero, S. E., Figini, M., Frigerio, B., Lusso, P., Mollica, L. and Lopalco, L. (2009). Protective versus pathogenic anti-CD4 immunity: insights from the study of natural resistance to HIV infection. J Transl Med 7: 101.
  23. Hirbod, T., Kaldensjo, T., Lopalco, L., Klareskog, E., Andersson, S., Uberti-Foppa, C., Ferrari, D., Manghi, M., Andersson, J., Lore, K. and Broliden, K. (2009). Abundant and superficial expression of C-type lectin receptors in ectocervix of women at risk of HIV infection. J Acquir Immune Defic Syndr 51(3): 239-247.
  24. Tudor, D., Derrien, M., Diomede, L., Drillet, A. S., Houimel, M., Moog, C., Reynes, J. M., Lopalco, L. and Bomsel, M. (2009). HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis. Mucosal Immunol 2(5): 412-426.
  25. Titanji, K., Sammicheli, S., De Milito, A., Mantegani, P., Fortis, C., Berg, L., Karre, K., Travi, G., Tassandin, C., Lopalco, L., Rethi, B., Tambussi, G. and Chiodi, F. (2008). Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection. Immunology 123(2): 164-170.
  26. Pastori, C., Clivio, A., Diomede, L., Consonni, R., De Mori, G. M., Longhi, R., Colombo, G. and Lopalco, L. (2008). Two amino acid substitutions within the first external loop of CCR5 induce human immunodeficiency virus-blocking antibodies in mice and chickens. J Virol 82(8): 4125-4134.
  27. Lopalco, L. and Burastero, S. E. (2008). HIV-1 and the self-nonself connection: how to sleep with the enemy and be much better off. AIDS Rev 10(3): 162-171.
  28. Myazawa, M., Lopalco, L., Mazzotta, F., Lo, C. S., Veas, F. and Clerici, M. (2008). Immunologic and Genetic Factors Modulating the Susceptibility to HIV in Humans: Studies in HIV-Exposed but Uninfected Individuals. AIDS 22:1-15.
  29. Bomsel, M., Pastori, C., Tudor, D., Alberti, C., Garcia, S., Ferrari, D., Lazzarin, A. and Lopalco, L. (2007). Natural mucosal antibodies reactive with first extracellular loop of CCR5 inhibit HIV-1 transport across human epithelial cells. AIDS 21(1): 13-22.
  30. Biasin, M., Piacentini, L., Lo Caputo, S., Kanari, Y., Magri, G., Trabattoni, D., Naddeo, V., Lopalco, L., Clivio, A., Cesana, E., Fasano, F., Bergamaschi, C., Mazzotta, F., Miyazawa, M. and Clerici, M. (2007). Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: a possible role in the resistance to HIV of HIV-exposed seronegative individuals. J Infect Dis 195(7): 960-964.
  31. Fluur, C., Rethi, B., Thang, P. H., Vivar, N., Mowafi, F., Lopalco, L., Foppa, C. U., Karlsson, A., Tambussi, G. and Chiodi, F. (2007). Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control. AIDS 21(8): 1048-1050.
  32. Suy, A., Castro, P., Nomdedeu, M., Garcia, F., Lopez, A., Fumero, E., Gallart, T., Lopalco, L., Coll, O., Gatell, J. M. and Plana, M. (2007). Immunological profile of heterosexual highly HIV-exposed uninfected individuals: predominant role of CD4 and CD8 T-cell activation. J Infect Dis 196(8): 1191-1201.
  33. Pastori, C., Weiser, B., Barassi, C., Uberti-Foppa, C., Ghezzi, S., Longhi, R., Calori, G., Burger, H., Kemal, K., Poli, G., Lazzarin, A. and Lopalco, L. (2006). Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: a possible protective effect against disease progression. Blood 107(12): 4825-4833.
  34. Titanji, K., De Milito, A., Cagigi, A., Thorstensson, R., Grutzmeier, S., Atlas, A., Hejdeman, B., Kroon, F. P., Lopalco, L., Nilsson, A. and Chiodi, F. (2006). Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection. Blood 108(5): 1580-1587.
  35. Nguyen, M., Pean, P., Lopalco, L., Nouhin, J., Phoung, V., Ly, N., Vermisse, P., Henin, Y., Barre-Sinoussi, F., Burastero, S. E., Reynes, J. M., Carcelain, G. and Pancino, G. (2006). HIV-specific antibodies but not t-cell responses are associated with protection in seronegative partners of HIV-1-infected individuals in Cambodia. J Acquir Immune Defic Syndr 42(4): 412-419.
  36. Hirbod, T., Nilsson, J., Andersson, S., Uberti-Foppa, C., Ferrari, D., Manghi, M., Andersson, J., Lopalco, L. and Broliden, K. (2006). Upregulation of interferon-alpha and RANTES in the cervix of HIV-1-seronegative women with high-risk behavior. J Acquir Immune Defic Syndr 43(2): 137-143.
  37. Russo, S. and Lopalco, L. (2006). Is autoimmunity a component of natural immunity to HIV? Curr HIV Res 4(2): 177-190.
  38. Lopalco, L., Barassi, C., Paolucci, C., Breda, D., Brunelli, D., Nguyen, M., Nouhin, J., Luong, T. T., Truong, L. X., Clerici, M., Calori, G., Lazzarin, A., Pancino, G. and Burastero, S. E. (2005). Predictive value of anti-cell and anti-human immunodeficiency virus (HIV) humoral responses in HIV-1-exposed seronegative cohorts of European and Asian origin. J Gen Virol 86(Pt 2): 339-348.
  39. Barassi, C., Soprana, E., Pastori, C., Longhi, R., Buratti, E., Lillo, F., Marenzi, C., Lazzarin, A., Siccardi, A. G. and Lopalco, L. (2005). Induction of murine mucosal CCR5-reactive antibodies as an anti-human immunodeficiency virus strategy. J Virol 79(11): 6848-6858.
  40. Titanji, K., Chiodi, F., Bellocco, R., Schepis, D., Osorio, L., Tassandin, C., Tambussi, G., Grutzmeier, S., Lopalco, L. and De Milito, A. (2005). Primary HIV-1 infection sets the stage for important B lymphocyte dysfunctions. AIDS 19(17): 1947-1955.
Protocols by Lucia Lopalco
  1. Isolation and In vitro Activation of Mouse Peyer’s Patch Cells from Small Intestine Tissue