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Claudia Pastori


Biomedical Technician School Certificate, University of Milano, Faculty of Medicine, Milano, Italy, 1989

Current position

Research Technician, Immunobiology of HIV Unit, Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele, Milano, Italy (1991-present)


  1. Pastori, C., Diomede, L., Venuti, A., Fisher, G., Jarvik, J., Bomsel, M., Sanvito, F. and Lopalco, L. (2014). Induction of HIV-blocking anti-CCR5 IgA in Peyers's patches without histopathological alterations. J Virol 88(7): 3623-3635.
  2.  Brombin, C., Diomede, L., Tudor, D., Drillet, A. S., Pastori, C., Poli, E., Riva, A., Uberti-Foppa, C., Galli, M., Di Serio, C., Bomsel, M. and Lopalco, L. (2013). A nonparametric procedure for defining a new humoral immunologic profile in a pilot study on HIV infected patients. PLoS One 8(3): e58768.
  3.  Pastori, C., Tudor, D., Diomede, L., Drillet, A. S., Jegerlehner, A., Rohn, T. A., Bomsel, M. and Lopalco, L. (2012). Virus like particle based strategy to elicit HIV-protective antibodies to the alpha-helic regions of gp41. Virology 431(1-2): 1-11.
  4. Diomede, L., Nyoka, S., Pastori, C., Scotti, L., Zambon, A., Sherman, G., Gray, C. M., Sarzotti-Kelsoe, M. and Lopalco, L. (2012). Passively transmitted gp41 antibodies in babies born from HIV-1 subtype C-seropositive women: correlation between fine specificity and protection. J Virol 86(8): 4129-4138.
  5.  Mestecky, J., Wright, P. F., Lopalco, L., Staats, H. F., Kozlowski, P. A., Moldoveanu, Z., Alexander, R. C., Kulhavy, R., Pastori, C., Maboko, L., Riedner, G., Zhu, Y., Wrinn, T. and Hoelscher, M. (2011). Scarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative women. AIDS Res Hum Retroviruses 27(5): 469-486
  6.  Miyazawa, M., Lopalco, L., Mazzotta, F., Caputo, S. L., Veas, F., Clerici, M. and Group, E. S. (2009). The'immunologic advantage'of HIV-exposed seronegative individuals. Aids 23(2): 161-175.
  7. Pastori, C., Clivio, A., Diomede, L., Consonni, R., De Mori, G. M., Longhi, R., Colombo, G. and Lopalco, L. (2008). Two amino acid substitutions within the first external loop of CCR5 induce human immunodeficiency virus-blocking antibodies in mice and chickens. J Virol 82(8): 4125-4134.
  8. Bomsel, M., Pastori, C., Tudor, D., Alberti, C., Garcia, S., Ferrari, D., Lazzarin, A. and Lopalco, L. (2007). Natural mucosal antibodies reactive with first extracellular loop of CCR5 inhibit HIV-1 transport across human epithelial cells. AIDS 21(1): 13-22.
  9. Pastori, C., Weiser, B., Barassi, C., Uberti-Foppa, C., Ghezzi, S., Longhi, R., Calori, G., Burger, H., Kemal, K., Poli, G., Lazzarin, A. and Lopalco, L. (2006). Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: a possible protective effect against disease progression. Blood 107(12): 4825-4833.
  10. Barassi, C., Soprana, E., Pastori, C., Longhi, R., Buratti, E., Lillo, F., Marenzi, C., Lazzarin, A., Siccardi, A. G. and Lopalco, L. (2005). Induction of murine mucosal CCR5-reactive antibodies as an anti-human immunodeficiency virus strategy. J Virol 79(11): 6848-6858.
  11. Barassi, C., Marenzi, C., Pastori, C., Longhi, R., Lazzarin, A. and Lopalco, L. (2004). A new prospective against HIV infection: induction of murin CCR5-downregulating antibodies. New Microbiol 27(2 Suppl 1): 85-94.
  12. Clerici, M., Barassi, C., Devito, C., Pastori, C., Piconi, S., Trabattoni, D., Longhi, R., Hinkula, J., Broliden, K. and Lopalco, L. (2002). Serum IgA of HIV-exposed uninfected individuals inhibit HIV through recognition of a region within the alpha-helix of gp41. AIDS 16(13): 1731-1741.
  13. Pastori, C., Barassi, C., Lillo, F., Longhi, R., Capiluppi, B., Nozza, S., Galli, A., Uberti-Foppa, C., Lazzarin, A., Tambussi, G. and Lopalco, L. (2002). The effect of HAART on humoral immune response in primary HIV-1 infected patients. J Biol Regul Homeost Agents 16(1): 9-17.
  14. Clerici, M., Butto, S., Lukwiya, M., Saresella, M., Declich, S., Trabattoni, D., Pastori, C., Piconi, S., Fracasso, C., Fabiani, M., Ferrante, P., Rizzardini, G. and Lopalco, L. (2000). Immune activation in africa is environmentally-driven and is associated with upregulation of CCR5. Italian-Ugandan AIDS Project. AIDS 14(14): 2083-2092.
  15. Barassi, C., De Santis, C., Pastori, C., Marraccini, P., Ciuffreda, D., Capiluppi, B., Bressi, C., Siccardi, A. G., Lazzarin, A., Tambussi, G. and Lopalco, L. (2000). Early production of HIV-1 neutralising antibodies in patients following highly active antiretroviral treatment (HAART) during primary HIV infection. J Biol Regul Homeost Agents 14(1): 68-74.
  16. Pastori, C., Barassi, C., Piconi, S., Longhi, R., Villa, M. L., Siccardi, A. G., Clerici, M. and Lopalco, L. (2000). HIV neutralizing IgA in exposed seronegative subjects recognise an epitope within the gp41 coiled-coil pocket. J Biol Regul Homeost Agents 14(1): 15-21.
  17. Lopalco, L., Barassi, C., Pastori, C., Longhi, R., Burastero, S. E., Tambussi, G., Mazzotta, F., Lazzarin, A., Clerici, M. and Siccardi, A. G. (2000). CCR5-reactive antibodies in seronegative partners of HIV-seropositive individuals down-modulate surface CCR5 in vivo and neutralize the infectivity of R5 strains of HIV-1 In vitro. J Immunol 164(6): 3426-3433.
  18. Lopalco, L., Pastori, C., Cosma, A., Burastero, S. E., Capiluppi, B., Boeri, E., Beretta, A., Lazzarin, A. and Siccardi, A. G. (2000). Anti-cell antibodies in exposed seronegative individuals with HIV type 1-neutralizing activity. AIDS Res Hum Retroviruses 16(2): 109-115.
  19. Mazzoli, S., Lopalco, L., Salvi, A., Trabattoni, D., Lo Caputo, S., Semplici, F., Biasin, M., Bl, C., Cosma, A., Pastori, C., Meacci, F., Mazzotta, F., Villa, M. L., Siccardi, A. G. and Clerici, M. (1999). Human immunodeficiency virus (HIV)-specific IgA and HIV neutralizing activity in the serum of exposed seronegative partners of HIV-seropositive persons. J Infect Dis 180(3): 871-875.
  20. Lopalco, L., Pastori, C., Barassi, C., Furci, L., Burastero, S., Lillo, F., Boeri, E., Soldini, L., Tambussi, G., Lazzarin, A., Beretta, A. and Siccardi, A. G. (1997). Heterogeneity in exposed uninfected individuals. J Biol Regul Homeost Agents 11(1-2): 27-31.

Protocols by Claudia Pastori
  1. Isolation and In vitro Activation of Mouse Peyer’s Patch Cells from Small Intestine Tissue