Education

Ph.D., Molecular Biology, University of California, Berkeley, California, 1967

Current position

Head, Retrovirus Assembly Section, HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD (1999-present)

Publications (since 2010)

1. Jensen, S. M., Ruscetti, F. W., Rein, A., Bertolette, D. C., Saucedo, C. J., O'Keefe, B. R. and Jones, K. S. (2014). Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses. J Virol 88(4): 2327-2332.
   
2. Munro, J. B., Nath, A., Farber, M., Datta, S. A., Rein, A., Rhoades, E. and Mothes, W. (2014). A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles. J Virol 88(6): 3577-3585.
   
3. Nair, S., Sanchez-Martinez, S., Ji, X. and Rein, A. (2014). Biochemical and biological studies of mouse APOBEC3. J Virol 88(7): 3850-3860.
   
4. Grohman, J. K., Gorelick, R. J., Kottegoda, S., Allbritton, N. L., Rein, A. and Weeks, K. M. (2014). An immature retroviral RNA genome resembles a kinetically trapped intermediate state. J Virol 88(11): 6061-6068.
   
5. Aloia, A. L., Duffy, L., Pak, V., Lee, K. E., Sanchez-Martinez, S., Derse, D., Heidecker, G., Cornetta, K. and Rein, A. (2013). A reporter system for replication-competent gammaretroviruses: the inGluc-MLV-DERSE assay. Gene Ther 20(2): 169-176.
   
6. O'Carroll, I. P., Soheilian, F., Kamata, A., Nagashima, K. and Rein, A. (2013). Elements in HIV-1 Gag contributing to virus particle assembly. Virus Res 171(2): 341-345.
   
7. Stavrou, S., Nitta, T., Kotla, S., Ha, D., Nagashima, K., Rein, A. R., Fan, H. and Ross, S. R. (2013). Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex. Proc Natl Acad Sci U S A 110(22): 9078-9083.
   
8. Rein, A. (2013). Murine leukemia virus p12 functions include hitchhiking into the nucleus. Proc Natl Acad Sci U S A 110(23): 9195-9196.
   
9. Fang, X., Wang, J., O'Carroll, I. P., Mitchell, M., Zuo, X., Wang, Y., Yu, P., Liu, Y., Rausch, J. W., Dyba, M. A., Kjems, J., Schwieters, C. D., Seifert, S., Winans, R. E., Watts, N. R., Stahl, S. J., Wingfield, P. T., Byrd, R. A.*, Le Grice, S. F., Rein, A. and Wang, Y. X. (2013). An unusual topological structure of the HIV-1 Rev response element. Cell 155(3): 594-605. (*Co-corresponding author)
   
10. O'Carroll, I. P., Crist, R. M., Mirro, J., Harvin, D., Soheilian, F., Kamata, A., Nagashima, K. and Rein, A. (2012). Functional redundancy in HIV-1 viral particle assembly. J Virol 86(23): 12991-12996.
    
11. Sfanos, K. S., Aloia, A. L., De Marzo, A. M. and Rein, A. (2012). XMRV and prostate cancer--a 'final' perspective. Nat Rev Urol 9(2): 111-118.
    
12. Sanchez-Martinez, S., Aloia, A. L., Harvin, D., Mirro, J., Gorelick, R. J., Jern, P., Coffin, J. M. and Rein, A. (2012). Studies on the restriction of murine leukemia viruses by mouse APOBEC3. PLoS One 7(5): e38190.
    
13. Jones, C. P., Datta, S. A., Rein, A., Rouzina, I. and Musier-Forsyth, K. (2011). Matrix domain modulates HIV-1 Gag's nucleic acid chaperone activity via inositol phosphate binding. J Virol 85(4): 1594-1603.
    
14. Datta, S. A., Temeselew, L. G., Crist, R. M., Soheilian, F., Kamata, A., Mirro, J., Harvin, D., Nagashima, K., Cachau, R. E. and Rein, A. (2011). On the role of the SP1 domain in HIV-1 particle assembly: a molecular switch? J Virol 85(9): 4111-4121.
    
15. Ramalingam, D., Duclair, S., Datta, S. A., Ellington, A., Rein, A. and Prasad, V. R. (2011). RNA aptamers directed to human immunodeficiency virus type 1 Gag polyprotein bind to the matrix and nucleocapsid domains and inhibit virus production. J Virol 85(1): 305-314.
    
16. Datta, S. A., Heinrich, F., Raghunandan, S., Krueger, S., Curtis, J. E., Rein, A. and Nanda, H. (2011). HIV-1 Gag extension: conformational changes require simultaneous interaction with membrane and nucleic acid. J Mol Biol 406(2): 205-214.
    
17. Goicochea, N. L., Datta, S. A., Ayaluru, M., Kao, C., Rein, A. and Dragnea, B. (2011). Structure and stoichiometry of template-directed recombinant HIV-1 Gag particles. J Mol Biol 410(4): 667-680.
    
18. Rein, A., Datta, S. A., Jones, C. P. and Musier-Forsyth, K. (2011). Diverse interactions of retroviral Gag proteins with RNAs. Trends Biochem Sci 36(7): 373-380.
    
19. Sfanos, K. S., Aloia, A. L., Hicks, J. L., Esopi, D. M., Steranka, J. P., Shao, W., Sanchez-Martinez, S., Yegnasubramanian, S., Burns, K. H., Rein, A. and De Marzo, A. M. (2011). Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines. PLoS One 6(6): e20874.
    
20. Rein, A. (2011). Murine leukemia viruses: objects and organisms. Advances in virology 2011.
    
21. Datta, S. A., Zuo, X., Clark, P. K., Campbell, S. J., Wang, Y. X. and Rein, A. (2011). Solution properties of murine leukemia virus gag protein: differences from HIV-1 gag. J Virol 85(23): 12733-12741.
    
22. Wu, T., Datta, S. A., Mitra, M., Gorelick, R. J., Rein, A. and Levin, J. G. (2010). Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: biological implications. Virology 405(2): 556-567.
    
23. Nanda, H., Datta, S. A., Heinrich, F., Losche, M., Rein, A., Krueger, S. and Curtis, J. E. (2010). Electrostatic interactions and binding orientation of HIV-1 matrix studied by neutron reflectivity. Biophys J 99(8): 2516-2524.
    
24. Gherghe, C., Lombo, T., Leonard, C. W., Datta, S. A., Bess, J. W., Jr., Gorelick, R. J., Rein, A. and Weeks, K. M. (2010). Definition of a high-affinity Gag recognition structure mediating packaging of a retroviral RNA genome. Proc Natl Acad Sci U S A 107(45): 19248-19253.
    
25. Rein, A. (2010). Nucleic acid chaperone activity of retroviral Gag proteins. RNA Biol 7(6): 700-705.
    
26. Aloia, A. L., Sfanos, K. S., Isaacs, W. B., Zheng, Q., Maldarelli, F., De Marzo, A. M. and Rein, A. (2010). XMRV: a new virus in prostate cancer? Cancer Res 70(24): 10028-10033.