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Steven A. Porcelli

Education

M.D., Yale University, 1984

Current position

Professor in Microbiology and Immunology (Murray and Evelyne Weinstock Endowed Chair), Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA (since 2000)

Publications (last 5 years)

  1. Arora, P., Baena, A., Yu, K. O., Saini, N. K., Kharkwal, S. S., Goldberg, M. F., Kunnath-Velayudhan, S., Carreno, L. J., Venkataswamy, M. M., Kim, J., Lazar-Molnar, E., Lauvau, G., Chang, Y. T., Liu, Z., Bittman, R., Al-Shamkhani, A., Cox, L. R., Jervis, P. J., Veerapen, N., Besra, G. S. and Porcelli, S. A. (2014). A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity 40(1): 105-116.
  2. Wen, X., Rao, P., Carreno, L. J., Kim, S., Lawrenczyk, A., Porcelli, S. A., Cresswell, P. and Yuan, W. (2013). Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells. Proc Natl Acad Sci U S A 110(8): 2963-2968.
  3. Jervis, P. J., Graham, L. M., Foster, E. L., Cox, L. R., Porcelli, S. A. and Besra, G. S. (2012). New CD1d agonists: synthesis and biological activity of 6''-triazole-substituted alpha-galactosyl ceramides. Bioorg Med Chem Lett 22(13): 4348-4352.
  4. Yu, E. D., Girardi, E., Wang, J., Mac, T. T., Yu, K. O., Van Calenbergh, S., Porcelli, S. A. and Zajonc, D. M. (2012). Structural basis for the recognition of C20:2-alphaGalCer by the invariant natural killer T cell receptor-like antibody L363. J Biol Chem 287(2): 1269-1278.
  5. Venkataswamy, M. M., Goldberg, M. F., Baena, A., Chan, J., Jacobs, W. R., Jr. and Porcelli, S. A. (2012). In vitro culture medium influences the vaccine efficacy of Mycobacterium bovis BCG. Vaccine 30(6): 1038-1049.
  6. Sweeney, K. A., Dao, D. N., Goldberg, M. F., Hsu, T., Venkataswamy, M. M., Henao-Tamayo, M., Ordway, D., Sellers, R. S., Jain, P., Chen, B., Chen, M., Kim, J., Lukose, R., Chan, J., Orme, I. M., Porcelli, S. A. and Jacobs, W. R., Jr. (2011). A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis. Nat Med 17(10): 1261-1268.
  7. Arora, P., Venkataswamy, M. M., Baena, A., Bricard, G., Li, Q., Veerapen, N., Ndonye, R., Park, J. J., Lee, J. H., Seo, K. C., Howell, A. R., Chang, Y. T., Illarionov, P. A., Besra, G. S., Chung, S. K. and Porcelli, S. A. (2011). A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids. J Am Chem Soc 133(14): 5198-5201.
  8. Tohn, R., Blumenfeld, H., Haeryfar, S. M., Veerapen, N., Besra, G. S., Porcelli, S. A. and Delovitch, T. L. (2011). Stimulation of a shorter duration in the state of anergy by an invariant natural killer T cell agonist enhances its efficiency of protection from type 1 diabetes. Clin Exp Immunol 164(1): 26-41.
  9. Prados-Rosales, R., Baena, A., Martinez, L. R., Luque-Garcia, J., Kalscheuer, R., Veeraraghavan, U., Camara, C., Nosanchuk, J. D., Besra, G. S., Chen, B., Jimenez, J., Glatman-Freedman, A., Jacobs, W. R., Jr., Porcelli, S. A. and Casadevall, A. (2011). Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice. J Clin Invest 121(4): 1471-1483.
  10. Bricard, G., Venkataswamy, M. M., Yu, K. O., Im, J. S., Ndonye, R. M., Howell, A. R., Veerapen, N., Illarionov, P. A., Besra, G. S., Li, Q., Chang, Y. T. and Porcelli, S. A. (2010). Alpha-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents. PLoS One 5(12): e14374.
  11. Hinchey, J., Jeon, B. Y., Alley, H., Chen, B., Goldberg, M., Derrick, S., Morris, S., Jacobs, W. R., Jr., Porcelli, S. A. and Lee, S. (2011). Lysine auxotrophy combined with deletion of the SecA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosis. PLoS One 6(1): e15857.
  12. Park, J. J., Lee, J. H., Seo, K. C., Bricard, G., Venkataswamy, M. M., Porcelli, S. A. and Chung, S. K. (2010). Syntheses and biological activities of KRN7000 analogues having aromatic residues in the acyl and backbone chains with varying stereochemistry. Bioorg Med Chem Lett 20(3): 814-818.
  13. Veerapen, N., Reddington, F., Bricard, G., Porcelli, S. A. and Besra, G. S. (2010). Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000. Bioorg Med Chem Lett 20(11): 3223-3226.
  14. Jervis, P. J., Veerapen, N., Bricard, G., Cox, L. R., Porcelli, S. A. and Besra, G. S. (2010). Synthesis and biological activity of alpha-glucosyl C24:0 and C20:2 ceramides. Bioorg Med Chem Lett 20(12): 3475-3478.
  15. Park, J. J., Lee, J. H., Seo, K. C., Bricard, G., Venkataswamy, M. M., Porcelli, S. A. and Chung, S. K. (2010). Syntheses and biological activities of KRN7000 analogues having aromatic residues in the acyl and backbone chains with varying stereochemistry. Bioorg Med Chem Lett 20(3): 814-818.
  16. Ly, D., Tohn, R., Rubin, B., Blumenfeld, H., Besra, G. S., Veerapen, N., Porcelli, S. A. and Delovitch, T. L. (2010). An alpha-galactosylceramide C20:2 N-acyl variant enhances anti-inflammatory and regulatory T cell-independent responses that prevent type 1 diabetes. Clin Exp Immunol 160(2): 185-198.
  17. Kuns, R. D., Morris, E. S., Macdonald, K. P., Markey, K. A., Morris, H. M., Raffelt, N. C., Banovic, T., Don, A. L., Rowe, V., Burman, A. C., Clouston, A. D., Farah, C., Besra, G. S., Illarionov, P. A., Smyth, M. J., Porcelli, S. A. and Hill, G. R. (2009). Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration. Blood 113(23): 5999-6010.
  18. Venkataswamy, M. M., Baena, A., Goldberg, M. F., Bricard, G., Im, J. S., Chan, J., Reddington, F., Besra, G. S., Jacobs, W. R., Jr. and Porcelli, S. A. (2009). Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin. J Immunol 183(3): 1644-1656.
  19. Im, J. S., Arora, P., Bricard, G., Molano, A., Venkataswamy, M. M., Baine, I., Jerud, E. S., Goldberg, M. F., Baena, A., Yu, K. O., Ndonye, R. M., Howell, A. R., Yuan, W., Cresswell, P., Chang, Y. T., Illarionov, P. A., Besra, G. S. and Porcelli, S. A. (2009). Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation. Immunity 30(6): 888-898.
Protocols by Steven A. Porcelli
  1. Isolation and in vivo Transfer of Antigen Presenting Cells