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Daan C. Swarts


Ph.D. in Biochemistry, Agrotechnology and Food Science Group, Laboratory of Microbiology, Wageningen University, The Netherlands, 2015

Current position

Postdoctoral fellow, Department of Biochemistry, University of Zurich, Switzerland (07/2016-now)


  1. Swarts, D. C., Hegge, J. W., Hinojo, I., Shiimori, M., Ellis, M. A., Dumrongkulraksa, J., Terns, R. M., Terns, M. P. and van der Oost, J. (2015). Argonaute of the archaeon Pyrococcus furiosus is a DNA-guided nuclease that targets cognate DNA. Nucleic Acids Res 43(10): 5120-5129.
  2. Swarts, D. C., Koehorst, J. J., Westra, E. R., Schaap, P. J. and van der Oost, J. (2015). Effects of argonaute on gene expression in Thermus thermophilus. PLoS One 10(4): e0124880.      
  3. Swarts, D. C., Makarova, K., Wang, Y., Nakanishi, K., Ketting, R. F., Koonin, E. V., Patel, D. J. and van der Oost, J. (2014). The evolutionary journey of Argonaute proteins. Nat Struct Mol Biol 21(9): 743-753.
  4. Swarts, D. C., Jore, M. M., Westra, E. R., Zhu, Y., Janssen, J. H., Snijders, A. P., Wang, Y., Patel, D. J., Berenguer, J., Brouns, S. J. and van der Oost, J. (2014). DNA-guided DNA interference by a prokaryotic Argonaute. Nature 507(7491): 258-261.
  5. Swarts, D. C., Jore, M. M. and van der Oost, J. (2014). Expression and purification of the Thermus thermophilus argonaute protein. Bio-protocol 4(19): e1253.
  6. Swarts, D. C., Westra, E. R., Brouns, S. J. and van der Oost, J. (2014). Purification and sequencing of DNA guides from prokaryotic argonaute. Bio-protocol 4(22): e1293. 
  7. Swarts, D. C., Mosterd, C., van Passel, M. W. and Brouns, S. J. (2012). CRISPR interference directs strand specific spacer acquisition. PLoS One 7(4): e35888.
  8. van der Oost, J., Swarts, D. C. and Jore, M. M. (2014). Prokaryotic Argonautes - variations on the RNA interference theme. Microbial Cell 1 (5): 158-159.
  9. Kunne, T., Swarts, D. C. and Brouns, S. J. (2014). Planting the seed: target recognition of short guide RNAs. Trends Microbiol 22(2): 74-83.
  10. Sheng, G., Zhao, H., Wang, J., Rao, Y., Tian, W., Swarts, D. C., van der Oost, J., Patel, D. J. and Wang, Y. (2014). Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc Natl Acad Sci U S A 111(2): 652-657.
  11. Westra, E. R., Swarts, D. C., Staals, R. H., Jore, M. M., Brouns, S. J. and van der Oost, J. (2012). The CRISPRs, they are a-changin': how prokaryotes generate adaptive immunity. Annu Rev Genet 46: 311-339.
  12. Plugge, C. M., Henstra, A. M., Worm, P., Swarts, D. C., Paulitsch-Fuchs, A. H., Scholten, J. C., Lykidis, A., Lapidus, A. L., Goltsman, E., Kim, E., McDonald, E., Rohlin, L., Crable, B. R., Gunsalus, R. P., Stams, A. J. and McInerney, M. J. (2012). Complete genome sequence of Syntrophobacter fumaroxidans strain (MPOB(T)). Stand Genomic Sci 7(1): 91-106.
  13. Blombach, F., Launay, H., Zorraquino, V., Swarts, D. C., Cabrita, L. D., Benelli, D., Christodoulou, J., Londei, P. and van der Oost, J. (2011). An HflX-type GTPase from Sulfolobus solfataricus binds to the 50S ribosomal subunit in all nucleotide-bound states. J Bacteriol 193(11): 2861-2867.
Protocols by Daan C. Swarts
  1. Expression and Purification of the Thermus thermophilus Argonaute Protein
  2. Purification and Sequencing of DNA Guides from Prokaryotic Argonaute