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Yi-Ping Hsueh

Education

Ph.D. in Immunology, Graduate Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan, 1995

Current position

Research Fellow, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

Publications (since 2005)

  1. Chuang, H. C., Huang, T. N., and Hsueh, Y. P. (2014). Neuronal excitation up-regulates Tbr1, a high-confidence risk gene of autism, mediating Grin2b expression in the adult brain. Frontiers in Cellular Neuroscience 8:280.
  2. Hu, H. T. and Hsueh, Y. P. (2014). Calcium influx and postsynaptic proteins coordinate the dendritic filopodium-spine transition. Dev Neurobiol 74(10): 1011-1029.
  3. Liu, H. Y.* Chen, C. Y.* and Hsueh, Y. P.* (2014). Innate immune responses regulate morphogenesis and degeneration: roles of Toll-like receptors and Sarm1 in neurons. Neurosci Bull 30(4): 645-654. (Invited review; *Co-corresponding authors)
  4. Shih, P. Y., Lee, S. P., Chen, Y. K. and Hsueh, Y. P. (2014). Cortactin-binding protein 2 increases microtubule stability and regulates dendritic arborization. J Cell Sci 127(Pt 16): 3521-3534.
    *Highlighted by cover image and “In this issue” of JCS
  5. Lin, C. W., Chen, C. Y., Cheng, S. J., Hu, H. T. and Hsueh, Y. P. (2014). Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator. Front Cell Neurosci 8: 87.
  6. Lin, C. W. and Hsueh, Y. P. (2014). Sarm1, a neuronal inflammatory regulator, controls social interaction, associative memory and cognitive flexibility in mice. Brain Behav Immun 37: 142-151.
  7. Lin, C. W., Liu, H. Y., Chen, C. Y. and Hsueh, Y. P. (2014). Neuronally-expressed Sarm1 regulates expression of inflammatory and antiviral cytokines in brains. Innate Immun 20(2): 161-172. (First published online ahead on June 10, 2013)
  8. Huang, T. N.*, Chuang, H. C.*, Chou, W. H., Chen, C. Y., Wang, H. F., Chou, S. J. and Hsueh, Y. P. (2014). Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. Nat Neurosci 17(2): 240-247. (*Co-first authors)
  9. Liu, H. Y., Hong, Y. F., Huang, C. M., Chen, C. Y., Huang, T. N. and Hsueh, Y. P. (2013). TLR7 negatively regulates dendrite outgrowth through the Myd88-c-Fos-IL-6 pathway. J Neurosci 33(28): 11479-11493.
  10. Gnanasekaran, A., Sundukova, M., Hullugundi, S., Birsa, N., Bianchini, G., Hsueh, Y. P., Nistri, A. and Fabbretti, E. (2013). Calcium/calmodulin-dependent serine protein kinase (CASK) is a new intracellular modulator of P2X3 receptors. J Neurochem 126(1): 102-112.
  11. Chen, Y. K., Chen, C. Y., Hu, H. T. and Hsueh, Y. P. (2012). CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex. Mol Biol Cell 23(22): 4383-4392.
  12. Hsueh, Y. P. (2012). Neuron-specific regulation on F-actin cytoskeletons: The role of CTTNBP2 in dendritic spinogenesis and maintenance. Commun Integr Biol 5(4): 334-336. (Invited short communication)
  13. Hsueh, Y. P. (2012). From neurodevelopment to neurodegeneration: the interaction of neurofibromin and valosin-containing protein/p97 in regulation of dendritic spine formation. J Biomed Sci 19: 33. (Invited review)
  14. Chen, Y. K. and Hsueh, Y. P. (2012). Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance. J Neurosci 32(3): 1043-1055.
    *Highlighted by cover image and “This week in the Journal” of JN
  15. Wang, H. F. #, Shih, Y. T. #, Chen, C. Y. #, Chao, H. W., Lee, M. J. * and Hsueh, Y. P. * (2011). Valosin-containing protein and neurofibromin interact to regulate dendritic spine density. J Clin Invest 121(12): 4820-4837. (#Co-first authors; *Co-corresponding authors)
    *Highlighted by a commentary in the same issue of JCI
  16. Hsueh, Y. P. (2011). A versatile player. J Mol Biol 412(1): 1-2. (Invited commentary on “The molecular Basis of the Caskin1 and Mint1 interaction with CASK” by Stafford et al., JMB 412:3-13).
  17. Chung, W. C., Huang, T. N. and Hsueh, Y. P. (2011). Targeted deletion of CASK-interacting nucleosome assembly protein causes higher locomotor and exploratory activities. Neurosignals 19(3): 128-141.
  18. Chen, C. Y., Lin, C. W., Chang, C. Y., Jiang, S. T. and Hsueh, Y. P. (2011). Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology. J Cell Biol 193(4): 769-784.
    *Selected for early release
    *Ranked up to #24 of the most-read articles in JCB
  19. Kuo, T. Y., Chen, C. Y. and Hsueh, Y. P. (2010). Bcl11A/CTIP1 mediates the effect of the glutamate receptor on axon branching and dendrite outgrowth. J Neurochem 114(5): 1381-1392.
  20. Kuo, T. Y., Hong, C. J., Chien, H. L. and Hsueh, Y. P. (2010). X-linked mental retardation gene CASK interacts with Bcl11A/CTIP1 and regulates axon branching and outgrowth. J Neurosci Res 88(11): 2364-2373.
    *Selected as cover for the issue
  21. Huang, T. N., Chang, H. P. and Hsueh, Y. P. (2010). CASK phosphorylation by PKA regulates the protein-protein interactions of CASK and expression of the NMDAR2b gene. J Neurochem 112(6): 1562-1573.
  22. Hsueh, Y. P. (2009). Calcium/calmodulin-dependent serine protein kinase and mental retardation. Ann Neurol 66(4): 438-443. (Invited review)
  23. Kuo, T. Y., Hong, C. J. and Hsueh, Y. P. (2009). Bcl11A/CTIP1 regulates expression of DCC and MAP1b in control of axon branching and dendrite outgrowth. Mol Cell Neurosci 42(3): 195-207.
  24. Huang, T. N. and Hsueh, Y. P. (2009). CASK point mutation regulates protein-protein interactions and NR2b promoter activity. Biochem Biophys Res Commun 382(1): 219-222.
  25. Chao, H. W., Hong, C. J., Huang, T. N., Lin, Y. L. and Hsueh, Y. P. (2008). SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis. J Cell Biol 182(1): 141-155.
    *Selected for early release
    *Highlighted by Faculty of 1000 Biology
  26. Lin, Y. L. and Hsueh, Y. P. (2008). Neurofibromin interacts with CRMP-2 and CRMP-4 in rat brain. Biochem Biophys Res Commun 369(2): 747-752.
  27. Samuels, B. A., Hsueh, Y. P., Shu, T., Liang, H., Tseng, H. C., Hong, C. J., Su, S. C., Volker, J., Neve, R. L., Yue, D. T. and Tsai, L. H. (2007). Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 56(5): 823-837.
  28. Hsueh, Y. P. (2007). Transcriptional Regulation of the Tbr1-CASK-CINAP Protein Complex in Response to Neuronal Activity. In: Dudek, S. (ed). The Regulation of Transcription by Neuronal Activity. Springer Science Publishing. (Invited book chapter)
  29. Hsueh, Y. P. (2007). Neurofibromin signaling and synapses. J Biomed Sci 14(4): 461-466. (Invited review)
  30. Lin, Y. L., Lei, Y. T., Hong, C. J. and Hsueh, Y. P. (2007). Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway. J Cell Biol 177(5): 829-841.
  31. Kuo, T. Y. and Hsueh, Y. P. (2007). Expression of zinc finger transcription factor Bcl11A/Evi9/CTIP1 in rat brain. J Neurosci Res 85(8): 1628-1636.
  32. Su, K. Y., Chien, W. L., Fu, W. M., Yu, I. S., Huang, H. P., Huang, P. H., Lin, S. R., Shih, J. Y., Lin, Y. L., Hsueh, Y. P., Yang, P. C. and Lin, S. W. (2007). Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory. J Neurosci 27(10): 2513-2524.
  33. Hong, C. J. and Hsueh, Y. P. (2007). Cytoplasmic distribution of T-box transcription factor Tbr-1 in adult rodent brain. J Chem Neuroanat 33(3): 124-130.
  34. Hong, C. J. and Hsueh, Y. P. (2006). CASK associates with glutamate receptor interacting protein and signaling molecules. Biochem Biophys Res Commun 351(3): 771-776.
  35. Hsueh, Y. P. (2006). The role of the MAGUK protein CASK in neural development and synaptic function. Curr Med Chem 13(16): 1915-1927.
  36. Lin, C. W., Huang, T. N., Wang, G. S., Kuo, T. Y., Yen, T. Y. and Hsueh, Y. P. (2006). Neural activity- and development-dependent expression and distribution of CASK interacting nucleosome assembly protein in mouse brain. J Comp Neurol 494(4): 606-619.
Protocols by Yi-Ping Hsueh
  1. Novel Object Recognition for Studying Memory in Mice
  2. Two-choice Digging Task in Mouse for Studying the Cognitive Flexibility