Welcome guest, Login | Register


Youjun Feng


Ph.D. in Molecular Immunology and Molecular Virology, Institute of Microbiology/Graduate School in Chinese Academy of Sciences (CAS), Beijing, China, 2007

Current position

Professor at Center for Infection & Immunity, Department of Medical Microbiology & Parasitology, Zhejiang University School of Medicine, 2014

Publications (since 2005)

  1. Shi, Z., Xuan, C., Han, H., Cheng, X., Wang, J., Feng, Y., Srinivas, S., Lu, G. and Gao, G. F. (2014). Gluconate 5-dehydrogenase (Ga5DH) participates in Streptococcus suis cell division. Protein & cell: 1-9.
  2. Feng, Y. and Cronan, J. E. (2014). PdhR, the pyruvate dehydrogenase repressor, does not regulate lipoic acid synthesis. Res Microbiol 165(6): 429-438.
  3. Feng, Y.*, Zhang, H., Wu, Z., Wang, S., Cao, M., Hu, D. and Wang, C. (2014). Streptococcus suis infection: an emerging/reemerging challenge of bacterial infectious diseases? Virulence 5(4): 477-497. (*Corresponding author)
  4. Hu, D., Zhang, F., Zhang, H., Hao, L., Gong, X., Geng, M., Cao, M., Zheng, F., Zhu, J., Pan, X., Tang, J., Feng, Y.* and Wang, C.* (2014). The beta-galactosidase (BgaC) of the zoonotic pathogen Streptococcus suis is a surface protein without the involvement of bacterial virulence. Sci Rep 4: 4140. (*Corresponding author)
  5. Yang, W., Lian, J., Feng, Y., Srinivas, S., Guo, Z., Zhong, H., Zhuang, Z. and Wang, S. (2014). Genome-wide miRNA-profiling of aflatoxin B1-induced hepatic injury using deep sequencing. Toxicology Letters 226(2): 140-149.
  6. Feng, Y., Napier, B. A., Manandhar, M., Henke, S. K., Weiss, D. S. and Cronan, J. E. (2014). A Francisella virulence factor catalyses an essential reaction of biotin synthesis. Mol Microbiol 91(2): 300-314.
  7. Zhang, J.#, Feng, Y.#, Hu, D., Lv, H., Zhu, J., Cao, M., Zheng, F., Zhu, J., Gong, X., Hao, L., Srinivas, S., Ren, H., Qi, Z., Li, B. and Wang, C. (2013). Rapid and sensitive detection of H7N9 avian influenza virus by use of reverse transcription-loop-mediated isothermal amplification. J Clin Microbiol 51(11): 3760-3764. (#Co-first author)
  8. Liu, H., Srinivas, S., He, X., Gong, G., Dai, C., Feng, Y.*, Chen, X.* and Wang, S.* (2013). Quorum Sensing in Vibrio and its Relevance to Bacterial Virulence. J Bacteriol Parasitol 4(172): 2. (*Corresponding author)
  9. Goble, A. M.#, Feng, Y.#, Raushel, F. M. and Cronan, J. E. (2013). Discovery of a cAMP deaminase that quenches cyclic AMP-dependent regulation. ACS Chem Biol 8(12): 2622-2629. (#Co-first author)
  10. Feng, Y.*, Xu, J., Zhang, H., Chen, Z. and Srinivas, S. (2013). Brucella BioR regulator defines a complex regulatory mechanism for bacterial biotin metabolism. J Bacteriol 195(15): 3451-3467. (*Corresponding author)
  11. Fang, Y., Feng, Y., Wu, T., Srinivas, S., Yang, W., Fan, J., Yang, C. and Wang, S. (2013). Aflatoxin B1 negatively regulates Wnt/beta-catenin signaling pathway through activating miR-33a. PLoS One 8(8): e73004.
  12. Wang, R., Xiang, S., Feng, Y., Srinivas, S., Zhang, Y., Lin, M. and Wang, S. (2013). Engineering production of functional scFv antibody in E. coli by co-expressing the molecule chaperone Skp. Front Cell Infect Microbiol 3: 72.
  13. Biswas, R. K., Dutta, D., Tripathi, A., Feng, Y., Banerjee, M. and Singh, B. N. (2013). Identification and characterization of Rv0494: a fatty acid-responsive protein of the GntR/FadR family from Mycobacterium tuberculosis. Microbiology 159(Pt 5): 913-923.
  14. Feng, Y., Zhang, H. and Cronan, J. E. (2013). Profligate biotin synthesis in alpha-proteobacteria - a developing or degenerating regulatory system? Mol Microbiol 88(1): 77-92.
  15. Wang, J., Wang, F., Feng, Y., Mi, K., Chen, Q., Shang, J. and Chen, B. (2013). Comparative vesicle proteomics reveals selective regulation of protein expression in chestnut blight fungus by a hypovirus. J Proteomics 78: 221-230.
  16. Feng, Y. and Cronan, J. E. (2012). Crosstalk of Escherichia coli FadR with global regulators in expression of fatty acid transport genes. PLoS One 7(9): e46275.
  17. Feng, Y., Zhang, H., Cao, M. and Wang, C. (2012). Regulation of virulence in Streptococcus suis. J Bacteriol Parasitol 3: e108. (*Corresponding author)
  18. Feng, Y., Cao, M., Shi, J., Zhang, H., Hu, D., Zhu, J., Zhang, X., Geng, M., Zheng, F., Pan, X., Li, X., Hu, F., Tang, J. and Wang, C. (2012). Attenuation of Streptococcus suis virulence by the alteration of bacterial surface architecture. Sci Rep 2: 710.
  19. Bi, H., Christensen, Q. H., Feng, Y., Wang, H. and Cronan, J. E. (2012). The Burkholderia cenocepacia BDSF quorum sensing fatty acid is synthesized by a bifunctional crotonase homologue having both dehydratase and thioesterase activities. Mol Microbiol 83(4): 840-855.
  20. Feng, Y., Cao, M., Wu, Z., Chu, F. and Ma, Y. (2011). Streptococcus suis in Omics-Era: Where Do We Stand. J Bacteriol Parasitol S2-001. doi 10: 2155-9597. (*Corresponding author)
  21. Cao, M., Feng, Y., Wang, C., Zheng, F., Li, M., Liao, H., Mao, Y., Pan, X., Wang, J., Hu, D., Hu, F. and Tang, J. (2011). Functional definition of LuxS, an autoinducer-2 (AI-2) synthase and its role in full virulence of Streptococcus suis serotype 2. J Microbiol 49(6): 1000-1011.
  22. Peng, H., Feng, Y., Zhu, X., Lan, X., Tang, M., Wang, J., Dong, H. and Chen, B. (2011). MoDUO1, a Duo1-like gene, is required for full virulence of the rice blast fungus Magnaporthe oryzae. Curr Genet 57(6): 409-420.
  23. Feng, Y. and Cronan, J. E. (2011). The Vibrio cholerae fatty acid regulatory protein, FadR, represses transcription of plsB, the gene encoding the first enzyme of membrane phospholipid biosynthesis. Mol Microbiol 81(4): 1020-1033.
  24. Liu, J., Dai, L., Qi, J., Gao, F., Feng, Y., Liu, W., Yan, J. and Gao, G. F. (2011). Diverse peptide presentation of rhesus macaque major histocompatibility complex class I Mamu-A 02 revealed by two peptide complex structures and insights into immune escape of simian immunodeficiency virus. J Virol 85(14): 7372-7383.
  25. Feng, Y. and Cronan, J. E. (2011). Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters. Mol Microbiol 80(1): 195-218.
  26. Zheng, F., Ji, H., Cao, M., Wang, C., Feng, Y., Li, M., Pan, X., Wang, J., Qin, Y., Hu, F. and Tang, J. (2011). Contribution of the Rgg transcription regulator to metabolism and virulence of Streptococcus suis serotype 2. Infect Immun 79(3): 1319-1328.
  27. Feng, Y. and Cronan, J. E. (2010). Overlapping repressor binding sites result in additive regulation of Escherichia coli FadH by FadR and ArcA. J Bacteriol 192(17): 4289-4299.
  28. Feng, Y., Zhang, H., Ma, Y. and Gao, G. F. (2010). Uncovering newly emerging variants of Streptococcus suis, an important zoonotic agent. Trends Microbiol 18(3): 124-131.
  29. Yi, Y., Ma, Y., Gao, F., Mao, X., Peng, H., Feng, Y., Fan, Z., Wang, G., Guo, G., Yan, J., Zeng, H., Zou, Q. and Gao, G. F. (2010). Crystal structure of EHEC intimin: insights into the complementarity between EPEC and EHEC. PLoS One 5(12): e15285.
  30. Feng, Y. and Cronan, J. E. (2009). A new member of the Escherichia coli fad regulon: transcriptional regulation of fadM (ybaW). J Bacteriol 191(20): 6320-6328.
  31. Feng, Y. and Cronan, J. E. (2009). Escherichia coli unsaturated fatty acid synthesis: complex transcription of the fabA gene and in vivo identification of the essential reaction catalyzed by FabB. J Biol Chem 284(43): 29526-29535.
  32. Feng, Y., Pan, X., Sun, W., Wang, C., Zhang, H., Li, X., Ma, Y., Shao, Z., Ge, J., Zheng, F., Gao, G. F. and Tang, J. (2009). Streptococcus suis enolase functions as a protective antigen displayed on the bacterial cell surface. J Infect Dis 200(10): 1583-1592.
  33. Feng, Y., Shi, X., Zhang, H., Zhang, S., Ma, Y., Zheng, B., Han, H., Lan, Q., Tang, J., Cheng, J., Gao, G. F. and Hu, Q. (2009). Recurrence of human Streptococcus suis infections in 2007: three cases of meningitis and implications that heterogeneous S. suis 2 circulates in China. Zoonoses Public Health 56(9-10): 506-514.
  34. Ge, J.#, Feng, Y.#, Ji, H., Zhang, H., Zheng, F., Wang, C., Yin, Z., Pan, X. and Tang, J. (2009). Inactivation of dipeptidyl peptidase IV attenuates the virulence of Streptococcus suis serotype 2 that causes streptococcal toxic shock syndrome. Curr Microbiol 59(3): 248-255. (#Co-first author).
  35. Cheng, Y.#, Feng, Y.#, Luo, P., Gu, J., Yu, S., Zhang, W. J., Liu, Y. Q., Wang, Q. X., Zou, Q. M. and Mao, X. H. (2009). Fusion expression and immunogenicity of EHEC EspA-Stx2Al protein: implications for the vaccine development. J Microbiol 47(4): 498-505. (#Co-first author).
  36. Ma, Y., Feng, Y., Liu, D. and Gao, G. F. (2009). Avian influenza virus, Streptococcus suis serotype 2, severe acute respiratory syndrome-coronavirus and beyond: molecular epidemiology, ecology and the situation in China. Philos Trans R Soc Lond B Biol Sci 364(1530): 2725-2737.
  37. Wang, C., Li, M., Feng, Y., Zheng, F., Dong, Y., Pan, X., Cheng, G., Dong, R., Hu, D., Feng, X., Ge, J., Liu, D., Wang, J., Cao, M., Hu, F. and Tang, J. (2009). The involvement of sortase A in high virulence of STSS-causing Streptococcus suis serotype 2. Arch Microbiol 191(1): 23-33.
  38. Tian, X., Lu, G., Gao, F., Peng, H., Feng, Y., Ma, G., Bartlam, M., Tian, K., Yan, J., Hilgenfeld, R. and Gao, G. F. (2009). Structure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). J Mol Biol 392(4): 977-993.
  39. Pan, X., Ge, J., Li, M., Wu, B., Wang, C., Wang, J., Feng, Y., Yin, Z., Zheng, F., Cheng, G., Sun, W., Ji, H., Hu, D., Shi, P., Feng, X., Hao, X., Dong, R., Hu, F. and Tang, J. (2009). The orphan response regulator CovR: a globally negative modulator of virulence in Streptococcus suis serotype 2. J Bacteriol 191(8): 2601-2612.
  40. Feng, Y., Li, M., Zhang, H., Zheng, B., Han, H., Wang, C., Yan, J., Tang, J. and Gao, G. F. (2008). Functional definition and global regulation of Zur, a zinc uptake regulator in a Streptococcus suis serotype 2 strain causing streptococcal toxic shock syndrome. J Bacteriol 190(22): 7567-7578.
  41. Feng, Y., Zhao, T., Nguyen, T., Inui, K., Ma, Y., Nguyen, T. H., Nguyen, V. C., Liu, D., Bui, Q. A., To, L. T., Wang, C., Tian, K. and Gao, G. F. (2008). Porcine respiratory and reproductive syndrome virus variants, Vietnam and China, 2007. Emerg Infect Dis 14(11): 1774-1776.
  42. Li, M.#, Wang, C.#, Feng, Y.#, Pan, X., Cheng, G., Wang, J., Ge, J., Zheng, F., Cao, M., Dong, Y., Liu, D., Wang, J., Lin, Y., Du, H., Gao, G. F., Wang, X., Hu, F. and Tang, J. (2008). SalK/SalR, a two-component signal transduction system, is essential for full virulence of highly invasive Streptococcus suis serotype 2. PLoS One 3(5): e2080. (#Co-first author)
  43. Khan, A. H., Chu, F., Feng, Y., Zhang, Q., Qi, J. and Gao, G. F. (2008). Crystallization and preliminary crystallographic analysis of recombinant immunoglobulin G-binding protein from Streptococcus suis. Acta Crystallogr Sect F Struct Biol Cryst Commun 64(Pt 8): 757-759.
  44. Guo, Y., Guo, G., Mao, X., Zhang, W., Xiao, J., Tong, W., Liu, T., Xiao, B., Liu, X., Feng, Y. and Zou, Q. (2008). Functional identification of HugZ, a heme oxygenase from Helicobacter pylori. BMC Microbiol 8: 226.
  45. Ma, Y., Mao, X., Li, J., Li, H., Feng, Y., Chen, H., Luo, P., Gu, J., Yu, S., Zeng, H., Guo, G., Yang, K. and Zou, Q. (2008). Engineering an anti-Stx2 antibody to control severe infections of EHEC O157:H7. Immunol Lett 121(2): 110-115.
  46. Wang, G., Zhan, D., Li, L., Lei, F., Liu, B., Liu, D., Xiao, H., Feng, Y., Li, J., Yang, B., Yin, Z., Song, X., Zhu, X., Cong, Y., Pu, J., Wang, J., Liu, J., Gao, G. F. and Zhu, Q. (2008). H5N1 avian influenza re-emergence of Lake Qinghai: phylogenetic and antigenic analyses of the newly isolated viruses and roles of migratory birds in virus circulation. J Gen Virol 89(Pt 3): 697-702.
  47. Feng, Y., Zheng, F., Pan, X., Sun, W., Wang, C., Dong, Y., Ju, A. P., Ge, J., Liu, D., Liu, C., Yan, J., Tang, J. and Gao, G. F. (2007). Existence and characterization of allelic variants of Sao, a newly identified surface protein from Streptococcus suis. FEMS Microbiol Lett 275(1): 80-88.
  48. Feng, Y. and Gao, G. F. (2007). Towards our understanding of SARS-CoV, an emerging and devastating but quickly conquered virus. Comp Immunol Microbiol Infect Dis 30(5-6): 309-327.
  49. Chen, C.#, Tang, J.#, Dong, W.#, Wang, C.#, Feng, Y.#, Wang, J., Zheng, F., Pan, X., Liu, D., Li, M., Song, Y., Zhu, X., Sun, H., Feng, T., Guo, Z., Ju, A., Ge, J., Dong, Y., Sun, W., Jiang, Y., Wang, J., Yan, J., Yang, H., Wang, X., Gao, G. F., Yang, R., Wang, J. and Yu, J. (2007). A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates. PLoS One 2(3): e315. (#Co-first author)
  50. Tian, X., Feng, Y., Zhao, T., Peng, H., Yan, J., Qi, J., Jiang, F., Tian, K. and Gao, F. (2007). Molecular cloning, expression, purification and crystallographic analysis of PRRSV 3CL protease. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 63(8): 720-722.
  51. Tian, K., Yu, X., Zhao, T., Feng, Y., Cao, Z., Wang, C., Hu, Y., Chen, X., Hu, D., Tian, X., Liu, D., Zhang, S., Deng, X., Ding, Y., Yang, L., Zhang, Y., Xiao, H., Qiao, M., Wang, B., Hou, L., Wang, X., Yang, X., Kang, L., Sun, M., Jin, P., Wang, S., Kitamura, Y., Yan, J. and Gao, G. F. (2007). Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS One 2(6): e526.
  52. Feng, Y., Qi, J., Zhang, H., Wang, J., Liu, J., Jiang, F. and Gao, F. (2006). X-ray crystallographic characterization of rhesus macaque MHC Mamu-A*02 complexed with an immunodominant SIV-Gag nonapeptide. Acta Crystallogr Sect F Struct Biol Cryst Commun 62(Pt 1): 13-15.
  53. Tang, J.#, Wang, C.#, Feng, Y.#, Yang, W., Song, H., Chen, Z., Yu, H., Pan, X., Zhou, X. and Wang, H. (2006). Streptococcal toxic shock syndrome caused by Streptococcus suis serotype 2. PLoS Medicine 3(5): e151. (#Co-first author)
  54. Liu, C.#, Feng, Y.#, Gao, F., Zhang, Q. and Wang, M. (2006). Characterization of HCoV-229E fusion core: implications for structure basis of coronavirus membrane fusion. Biochem Biophys Res Commun 345(3): 1108-1115. (#Co-first author)
  55. Ma, G.#, Feng, Y.#, Gao, F., Wang, J., Liu, C. and Li, Y. (2005). Biochemical and biophysical characterization of the transmissible gastroenteritis coronavirus fusion core. Biochem Biophys Res Commun 337(4): 1301-1307. (#Co-first author)
  56. Liu, J., Xiao, H., Lei, F., Zhu, Q., Qin, K., Zhang, X. W., Zhang, X. L., Zhao, D., Wang, G., Feng, Y., Ma, J., Liu, W., Wang, J. and Gao, G. F. (2005). Highly pathogenic H5N1 influenza virus infection in migratory birds. Science 309(5738): 1206.
  57. Cheng, H., Jiang, N., Shen, A. and Feng, Y. (2005). Molecular cloning and functional expression of d-arabitol dehydrogenase gene from Gluconobacter oxydans in Escherichia coli. FEMS Microbiol Lett 252(1): 35-42.
Protocols by Youjun Feng
  1. Protocol for Biotin Bioassay-based Cross Feeding