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Vivien  Jane  Coulson-Thomas

Vivien Jane Coulson-Thomas


Ph.D, Molecular Biology Program, 
Department of Biochemistry, Discipline of Molecular Biology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil, 2010

Current position

Research Assistant Professor at the Department of Ophthalmology, University of Cincinnati, USA


  1. Coulson-Thomas, V. J., Coulson-Thomas, Y. M., Gesteira, T. F. and Kao, W. W. (2016). Extrinsic and Intrinsic Mechanisms by Which Mesenchymal Stem Cells Suppress the Immune System. Ocul Surf 14(2): 121-134. (Corresponding author)
  2. Smith, P. D.* Coulson-Thomas, V. J.*, Foscarin, S., Kwok, J. C. and Fawcett, J. W. (2015). "GAG-ing with the neuron": The role of glycosaminoglycan patterning in the central nervous system. Exp Neurol 274(Pt B): 100-114. (*Contributed equally)
  3. Coulson-Thomas, Y. M., Coulson-Thomas, V. J., Norton, A. L., Gesteira, T. F., Cavalheiro, R. P., Meneghetti, M. C., Martins, J. R., Dixon, R. A. and Nader, H. B. (2015). The identification of proteoglycans and glycosaminoglycans in archaeological human bones and teeth. PLoS One 10(6): e0131105.
  4. Coulson-Thomas, V. J., Chang, S. H., Yeh, L. K., Coulson-Thomas, Y. M., Yamaguchi, Y., Esko, J., Liu, C. Y. and Kao, W. (2015). Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing. Invest Ophthalmol Vis Sci 56(5): 3004-3014. (Corresponding author)
  5. Coulson-Thomas, Y. M., Gesteira, T. F., Norton, A. L., Kao, W. W., Nader, H. B. and Coulson-Thomas, V. J. (2015). The role of proteoglycans in the reactive stroma on tumor growth and progression. Histol Histopathol 30(1): 33-41.
  6. Coulson-Thomas, Y. M., Norton, A. L., Coulson-Thomas, V. J., Florencio-Silva, R., Ali, N., Elmrghni, S., Gil, C. D., Sasso, G. R., Dixon, R. A. and Nader, H. B. (2015). DNA and bone structure preservation in medieval human skeletons. Forensic Sci Int 251: 186-194.
  7. Coulson-Thomas, V. J., Gesteira, T. F., Esko, J. and Kao, W. (2014). Heparan sulfate regulates hair follicle and sebaceous gland morphogenesis and homeostasis. J Biol Chem 289(36): 25211-25226.
  8. Coulson-Thomas, V. J., Gesteira, T. F., Hascall, V. and Kao, W. (2014). Umbilical cord mesenchymal stem cells suppress host rejection: the role of the glycocalyx. J Biol Chem 289(34): 23465-23481. (Corresponding author)
  9. Cordula, C. R., Lima, M. A., Shinjo, S. K., Gesteira, T. F., Pol-Fachin, L., Coulson-Thomas, V. J., Verli, H., Yates, E. A., Rudd, T. R., Pinhal, M. A., Toma, L., Dietrich, C. P., Nader, H. B. and Tersariol, I. L. (2014). On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca2+. Mol Biosyst 10(1): 54-64.
  10. Coulson-Thomas, V. J., Caterson, B. and Kao, W. W. (2013). Transplantation of human umbilical mesenchymal stem cells cures the corneal defects of mucopolysaccharidosis VII mice. Stem Cells 31(10): 2116-2126. (Corresponding author)
  11. Gesteira, T. F., Pol-Fachin, L., Coulson-Thomas, V. J., Lima, M. A., Verli, H. and Nader, H. B. (2013). Insights into the N-sulfation mechanism: molecular dynamics simulations of the N-sulfotransferase domain of NDST1 and mutants. PLoS One 8(8): e70880.
  12. Yamanaka, O.*, Yuan, Y.*, Coulson-Thomas, V. J.*, Gesteira, T. F., Call, M. K., Zhang, Y., Zhang, J., Chang, S. H., Xie, C., Liu, C. Y., Saika, S., Jester, J. V. and Kao, W. W. (2013). Lumican binds ALK5 to promote epithelium wound healing. PLoS One 8(12): e82730. (*Contributed equally)
  13. Coulson-Thomas, V. J., Coulson-Thomas, Y. M., Gesteira, T. F., Andrade de Paula, C. A., Carneiro, C. R., Ortiz, V., Toma, L., Kao, W. W. and Nader, H. B. (2013). Lumican expression, localization and antitumor activity in prostate cancer. Exp Cell Res 319(7): 967-981. (Corresponding author)
  14. Pompei, L. M., Steiner, M. L., Theodoro, T. R., Souza, P. Z., Romanini, A. C., Coulson-Thomas, V., Pinhal, M. A. and Fernandes, C. E. (2013). Effect of estrogen therapy on vascular perlecan and metalloproteinases 2 and 9 in castrated rats. Climacteric 16(1): 147-153.
  15. de Paula, C. A., Coulson-Thomas, V. J., Ferreira, J. G., Maza, P. K., Suzuki, E., Nakahata, A. M., Nader, H. B., Sampaio, M. U. and Oliva, M. L. (2012). Enterolobium contortisiliquum trypsin inhibitor (EcTI), a plant proteinase inhibitor, decreases in vitro cell adhesion and invasion by inhibition of Src protein-focal adhesion kinase (FAK) signaling pathways. J Biol Chem 287(1): 170-182.
  16. Coulson-Thomas, V. J., Coulson-Thomas, Y. M., Gesteira, T. F., de Paula, C. A., Mader, A. M., Waisberg, J., Pinhal, M. A., Friedl, A., Toma, L. and Nader, H. B. (2011). Colorectal cancer desmoplastic reaction up-regulates collagen synthesis and restricts cancer cell invasion. Cell Tissue Res 346(2): 223-236. (Corresponding author)
  17. Gesteira, T. F., Coulson-Thomas, V. J., Ogata, F. T., Farias, E. H., Cavalheiro, R. P., de Lima, M. A., Cunha, G. L., Nakayasu, E. S., Almeida, I. C., Toma, L. and Nader, H. B. (2011). A novel approach for the characterisation of proteoglycans and biosynthetic enzymes in a snail model. Biochim Biophys Acta 1814(12): 1862-1869.
  18. Gesteira, T. F., Coulson-Thomas, V. J., Taunay-Rodrigues, A., Oliveira, V., Thacker, B. E., Juliano, M. A., Pasqualini, R., Arap, W., Tersariol, I. L., Nader, H. B., Esko, J. D. and Pinhal, M. A. (2011). Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1. J Biol Chem 286(7): 5338-5346.
  19. Coulson-Thomas, V. J., Gesteira, T. F., Coulson-Thomas, Y. M., Vicente, C. M., Tersariol, I. L., Nader, H. B. and Toma, L. (2010). Fibroblast and prostate tumor cell cross-talk: fibroblast differentiation, TGF-beta, and extracellular matrix down-regulation. Exp Cell Res 316(19): 3207-3226. (Corresponding author)
  20. Mergler, S., Valtink, M., Coulson-Thomas, V. J., Lindemann, D., Reinach, P. S., Engelmann, K. and Pleyer, U. (2010). TRPV channels mediate temperature-sensing in human corneal endothelial cells. Exp Eye Res 90(6): 758-770.
  21. Dreyfuss, J. L., Veiga, S. S., Coulson-Thomas, V. J., Santos, I. A., Toma, L., Coletta, R. D. and Nader, H. B. (2010). Differences in the expression of glycosaminoglycans in human fibroblasts derived from gingival overgrowths is related to TGF-beta up-regulation. Growth Factors 28(1): 24-33.
  22. Coulson-Thomas, Y. M., Coulson-Thomas, V. J., Filippo, T. R., Mortara, R. A., da Silveira, R. B., Nader, H. B. and Porcionatto, M. A. (2008). Adult bone marrow-derived mononuclear cells expressing chondroitinase AC transplanted into CNS injury sites promote local brain chondroitin sulphate degradation. J Neurosci Methods 171(1): 19-29.

Book charpters

  1. oulson-Thomas, V. J., Gesteira, T. F., Coulson-Thomas, Y. M., Nader, H. B. (2013). Post-Translational modifications. Encyclopedia of Biophysics, 1919-1923.
Protocols by Vivien Jane Coulson-Thomas
  1. Dimethylmethylene Blue Assay (DMMB)
  2. Analysis of Cancer Stromal Reaction Using an O-ring Co-culture Assay
  3. 3D Stroma Invasion Assay
  4. Isolation and Analysis of Proteoglycans and Glycosaminoglycans from Archaeological Bones and Teeth